Detailed information NTG0431194

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: HB751_RS07670
• Genome accession: NZ_CP050272
• Coordinates: 1578365..1579279 (-)
• Length: 304 a.a.
• NCBI ID: WP_019804618.1
• Uniprot ID: -
• Organism: Streptococcus mutans strain P6
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1573365..1584279

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HB751_RS07650 (HB751_07650)	-	1573748..1574131 (-)	384	WP_011074470.1	membrane protein	-
HB751_RS07655 (HB751_07655)	-	1574196..1574621 (-)	426	WP_002278431.1	low molecular weight protein-tyrosine-phosphatase	-
HB751_RS07660 (HB751_07660)	ruvB	1574659..1575654 (-)	996	WP_002284808.1	Holliday junction branch migration DNA helicase RuvB	-
HB751_RS07665 (HB751_07665)	-	1575989..1577830 (+)	1842	WP_002283787.1	carbohydrate-binding domain-containing protein	-
HB751_RS07670 (HB751_07670)	comR	1578365..1579279 (-)	915	WP_019804618.1	helix-turn-helix domain-containing protein	Regulator
HB751_RS07675 (HB751_07675)	-	1579664..1580350 (-)	687	WP_019804617.1	DNA alkylation repair protein	-
HB751_RS07680 (HB751_07680)	purB	1580370..1581668 (-)	1299	WP_002263398.1	adenylosuccinate lyase	-
HB751_RS07685 (HB751_07685)	-	1582014..1582823 (-)	810	WP_002283789.1	GyrI-like domain-containing protein	-
HB751_RS07690 (HB751_07690)	-	1582905..1583105 (-)	201	WP_024781816.1	hypothetical protein	-
HB751_RS07695 (HB751_07695)	-	1583203..1583895 (-)	693	WP_024781817.1	aspartate/glutamate racemase family protein	-

Sequence

Protein

• Length: 304 a.a.
• Molecular weight: 35290.45 Da
• Isoelectric Point: 5.0109

>NTDB_id=431194 HB751_RS07670 WP_019804618.1 1578365..1579279(-) (comR) [Streptococcus mutans strain P6]
MLKDFGKKIKSLRLEKGLTKEAVCLDESQLSTRQLTRIESGQSMPTLNKAIYIAGRLGVTLGYLTDGENVELPSRYKELK
YLLLRTPTYGDQQRLAEKETYFDEIFSQFYDDLPEEEQLIIDGLQSKLDIHFSDNIDFGVGILNDYFDQILRKTNYQVND
LILIDLYFSCLTVSGLDSAIFDSRKYNQLLETLLKQVDCLPLEDLFVLNNVLLNNFGLLLELKKYDFVKQLIAVSNKIMD
RTHDFQKKPIVNLLTWKHHLFVEKDYAKAKKSYDAAILFAQLTENINLRENLEKEWQKDSQNGT

Nucleotide

• Length: 915 bp

>NTDB_id=431194 HB751_RS07670 WP_019804618.1 1578365..1579279(-) (comR) [Streptococcus mutans strain P6]
ATGTTAAAAGATTTTGGGAAGAAAATTAAGAGCCTGAGGTTAGAAAAGGGGCTGACCAAAGAGGCTGTCTGCCTTGATGA
ATCGCAGTTGTCAACACGGCAGCTGACTAGAATTGAATCAGGACAGTCTATGCCAACTCTTAATAAAGCTATTTATATTG
CAGGACGTTTAGGAGTAACGCTTGGCTATTTAACGGACGGAGAAAATGTCGAGTTACCCAGTCGTTATAAAGAACTAAAG
TATTTATTATTACGAACGCCAACCTATGGCGATCAGCAAAGATTAGCCGAAAAAGAAACCTATTTTGACGAGATTTTTAG
TCAGTTTTATGATGATTTGCCTGAAGAAGAACAATTGATTATTGATGGCTTACAATCGAAACTAGATATTCATTTTAGTG
ACAATATCGATTTTGGCGTTGGTATTTTAAATGACTATTTTGATCAGATTTTAAGAAAAACCAATTATCAGGTCAATGAT
TTGATTCTGATTGATCTCTATTTTTCCTGCTTAACTGTTAGTGGTTTGGATTCAGCTATTTTTGATTCAAGAAAATATAA
TCAATTATTGGAGACATTGCTTAAGCAGGTAGACTGCCTTCCATTGGAAGATCTTTTCGTTTTAAATAATGTTTTATTGA
ATAATTTTGGACTCCTCTTAGAATTGAAAAAATATGATTTTGTTAAGCAGCTTATTGCTGTTAGCAATAAAATCATGGAT
AGAACTCATGATTTTCAAAAAAAGCCTATTGTTAATCTTCTGACATGGAAGCATCATTTATTTGTTGAAAAAGATTATGC
GAAAGCTAAAAAGAGCTATGATGCTGCTATCTTATTTGCCCAGTTAACAGAAAACATTAATTTAAGAGAAAATTTGGAGA
AAGAATGGCAAAAAGATTCTCAGAACGGGACATAA

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (73-296)

• Helix-turn-helix (HTH_3) (9-64)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus mutans UA159	99.013	100	0.99
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	52.778	94.737	0.5
comR	Streptococcus pyogenes MGAS315	47.492	98.355	0.467
comR	Streptococcus pyogenes MGAS8232	47.02	99.342	0.467
comR	Streptococcus suis P1/7	43.478	98.355	0.428
comR	Streptococcus suis 05ZYH33	43.478	98.355	0.428
comR	Streptococcus suis D9	37	98.684	0.365