Detailed information NTG0431146

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: HB752_RS09030
• Genome accession: NZ_CP050271
• Coordinates: 1847795..1848709 (-)
• Length: 304 a.a.
• NCBI ID: WP_019804618.1
• Uniprot ID: -
• Organism: Streptococcus mutans strain S1
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1842795..1853709

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HB752_RS09010 (HB752_09010)	-	1843178..1843561 (-)	384	WP_011074470.1	membrane protein	-
HB752_RS09015 (HB752_09015)	-	1843626..1844051 (-)	426	WP_002278431.1	low molecular weight protein-tyrosine-phosphatase	-
HB752_RS09020 (HB752_09020)	ruvB	1844089..1845084 (-)	996	WP_002284808.1	Holliday junction branch migration DNA helicase RuvB	-
HB752_RS09025 (HB752_09025)	-	1845419..1847260 (+)	1842	WP_002283787.1	carbohydrate-binding domain-containing protein	-
HB752_RS09030 (HB752_09030)	comR	1847795..1848709 (-)	915	WP_019804618.1	helix-turn-helix domain-containing protein	Regulator
HB752_RS09035 (HB752_09035)	-	1849094..1849780 (-)	687	WP_019804617.1	DNA alkylation repair protein	-
HB752_RS09040 (HB752_09040)	purB	1849800..1851098 (-)	1299	WP_002263398.1	adenylosuccinate lyase	-
HB752_RS09045 (HB752_09045)	-	1851444..1852253 (-)	810	WP_002283789.1	GyrI-like domain-containing protein	-
HB752_RS09050 (HB752_09050)	-	1852335..1852535 (-)	201	WP_024781816.1	hypothetical protein	-
HB752_RS09055 (HB752_09055)	-	1852633..1853325 (-)	693	WP_024781817.1	aspartate/glutamate racemase family protein	-

Sequence

Protein

• Length: 304 a.a.
• Molecular weight: 35290.45 Da
• Isoelectric Point: 5.0109

>NTDB_id=431146 HB752_RS09030 WP_019804618.1 1847795..1848709(-) (comR) [Streptococcus mutans strain S1]
MLKDFGKKIKSLRLEKGLTKEAVCLDESQLSTRQLTRIESGQSMPTLNKAIYIAGRLGVTLGYLTDGENVELPSRYKELK
YLLLRTPTYGDQQRLAEKETYFDEIFSQFYDDLPEEEQLIIDGLQSKLDIHFSDNIDFGVGILNDYFDQILRKTNYQVND
LILIDLYFSCLTVSGLDSAIFDSRKYNQLLETLLKQVDCLPLEDLFVLNNVLLNNFGLLLELKKYDFVKQLIAVSNKIMD
RTHDFQKKPIVNLLTWKHHLFVEKDYAKAKKSYDAAILFAQLTENINLRENLEKEWQKDSQNGT

Nucleotide

• Length: 915 bp

>NTDB_id=431146 HB752_RS09030 WP_019804618.1 1847795..1848709(-) (comR) [Streptococcus mutans strain S1]
ATGTTAAAAGATTTTGGGAAGAAAATTAAGAGCCTGAGGTTAGAAAAGGGGCTGACCAAAGAGGCTGTCTGCCTTGATGA
ATCGCAGTTGTCAACACGGCAGCTGACTAGAATTGAATCAGGACAGTCTATGCCAACTCTTAATAAAGCTATTTATATTG
CAGGACGTTTAGGAGTAACGCTTGGCTATTTAACGGACGGAGAAAATGTCGAGTTACCCAGTCGTTATAAAGAACTAAAG
TATTTATTATTACGAACGCCAACCTATGGCGATCAGCAAAGATTAGCCGAAAAAGAAACCTATTTTGACGAGATTTTTAG
TCAGTTTTATGATGATTTGCCTGAAGAAGAACAATTGATTATTGATGGCTTACAATCGAAACTAGATATTCATTTTAGTG
ACAATATCGATTTTGGCGTTGGTATTTTAAATGACTATTTTGATCAGATTTTAAGAAAAACCAATTATCAGGTCAATGAT
TTGATTCTGATTGATCTCTATTTTTCCTGCTTAACTGTTAGTGGTTTGGATTCAGCTATTTTTGATTCAAGAAAATATAA
TCAATTATTGGAGACATTGCTTAAGCAGGTAGACTGCCTTCCATTGGAAGATCTTTTCGTTTTAAATAATGTTTTATTGA
ATAATTTTGGACTCCTCTTAGAATTGAAAAAATATGATTTTGTTAAGCAGCTTATTGCTGTTAGCAATAAAATCATGGAT
AGAACTCATGATTTTCAAAAAAAGCCTATTGTTAATCTTCTGACATGGAAGCATCATTTATTTGTTGAAAAAGATTATGC
GAAAGCTAAAAAGAGCTATGATGCTGCTATCTTATTTGCCCAGTTAACAGAAAACATTAATTTAAGAGAAAATTTGGAGA
AAGAATGGCAAAAAGATTCTCAGAACGGGACATAA

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (73-296)

• Helix-turn-helix (HTH_3) (9-64)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus mutans UA159	99.013	100	0.99
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	52.778	94.737	0.5
comR	Streptococcus pyogenes MGAS315	47.492	98.355	0.467
comR	Streptococcus pyogenes MGAS8232	47.02	99.342	0.467
comR	Streptococcus suis P1/7	43.478	98.355	0.428
comR	Streptococcus suis 05ZYH33	43.478	98.355	0.428
comR	Streptococcus suis D9	37	98.684	0.365