Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   HB752_RS04110 Genome accession   NZ_CP050271
Coordinates   810545..811219 (+) Length   224 a.a.
NCBI ID   WP_002264509.1    Uniprot ID   -
Organism   Streptococcus mutans strain S1     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 805545..816219
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HB752_RS04090 (HB752_04090) pstB 805797..806555 (+) 759 WP_002262210.1 phosphate ABC transporter ATP-binding protein PstB -
  HB752_RS04095 (HB752_04095) phoU 806587..807240 (+) 654 WP_002262211.1 phosphate signaling complex protein PhoU -
  HB752_RS04100 (HB752_04100) - 807281..809830 (+) 2550 WP_002268743.1 M1 family metallopeptidase -
  HB752_RS04105 (HB752_04105) ciaX 810231..810494 (+) 264 WP_002262213.1 three-component system regulator CiaX -
  HB752_RS04110 (HB752_04110) ciaR 810545..811219 (+) 675 WP_002264509.1 three-component system response regulator CiaR Regulator
  HB752_RS04115 (HB752_04115) ciaH 811209..812516 (+) 1308 WP_002264510.1 three-component system sensor histidine kinase CiaH Regulator
  HB752_RS04120 (HB752_04120) rpsT 812605..812859 (-) 255 WP_011074586.1 30S ribosomal protein S20 -
  HB752_RS04125 (HB752_04125) coaA 812913..813833 (-) 921 WP_019804785.1 type I pantothenate kinase -
  HB752_RS04130 (HB752_04130) - 813929..814525 (+) 597 WP_002270201.1 class I SAM-dependent methyltransferase -
  HB752_RS04135 (HB752_04135) - 814634..815911 (+) 1278 WP_019804784.1 pyrimidine-nucleoside phosphorylase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25417.19 Da        Isoelectric Point: 4.3777

>NTDB_id=431119 HB752_RS04110 WP_002264509.1 810545..811219(+) (ciaR) [Streptococcus mutans strain S1]
MIKLLLVEDDLSLSNSIFDFLDDFADVMQVFDGAEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENNLTYGELTVDTATNTTMVNGKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKDTTFGKNLQTLRSVGYILKDAN

Nucleotide


Download         Length: 675 bp        

>NTDB_id=431119 HB752_RS04110 WP_002264509.1 810545..811219(+) (ciaR) [Streptococcus mutans strain S1]
ATGATAAAGTTATTATTAGTAGAAGACGATTTGAGTCTATCTAACTCTATCTTTGACTTTCTGGATGATTTTGCTGATGT
CATGCAGGTTTTTGATGGTGCAGAAGGACTGTATGAAGCAGAGAGTGGCGTTTATGATTTGATTCTATTAGACTTAATGC
TTCCTGAAAAAAATGGCTTCCAAGTTTTAAAAGAACTGCGTGAAAAAGGGATAACGACACCTGTTTTGATTATGACAGCT
AAGGAAGGTTTGGATGACAAAGGACACGGTTTTGAATTAGGAGCTGATGATTATCTGACAAAACCATTTTATCTTGAAGA
ATTAAAAATGCGTATTCAGGCCCTCCTCAAACGTTCAGGCAAATTCAACGAAAATAATCTGACTTACGGTGAGTTAACCG
TTGATACGGCAACTAATACAACAATGGTAAATGGAAAAGAAGTTGAACTGCTTGGCAAAGAGTTTGACTTATTAGTTTAT
TTCTTACAAAATCAAAATGTCATTTTACCTAAGTCACAAATTTTTGATCGTATCTGGGGCTTTGATAGCGATACGACAAT
TTCGGTTGTTGAAGTCTATGTTTCTAAAATCAGAAAAAAATTAAAAGATACCACATTTGGAAAGAATTTACAGACATTAC
GCAGTGTAGGATATATTTTGAAGGATGCTAATTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

99.554

100

0.996
  ciaR Streptococcus pneumoniae Rx1

87.946

100

0.879
  ciaR Streptococcus pneumoniae D39

87.946

100

0.879
  ciaR Streptococcus pneumoniae R6

87.946

100

0.879
  ciaR Streptococcus pneumoniae TIGR4

87.946

100

0.879
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.611

100

0.379
  vicR Streptococcus mutans UA159

35.622

100

0.371