Detailed information NTG0430539

Bioinformatically predicted

Overview

• Name: dprA/cilB/dalA
• Type: Machinery gene
• Locus tag: HA248_RS06270
• Genome accession: NZ_CP050175
• Coordinates: 1228560..1229408 (-)
• Length: 282 a.a.
• NCBI ID: WP_000705325.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain PZ900701590
• Function: ssDNA binding; loading RecA onto ssDNA; competence shut-off (predicted from homology) DNA processing Competence regulation

Genomic Context

Location: 1223560..1234408

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HA248_RS06255 (HA248_06245)	-	1223799..1224158 (-)	360	WP_001220357.1	YbaN family protein	-
HA248_RS06260 (HA248_06250)	topA	1224379..1226466 (-)	2088	WP_000179635.1	type I DNA topoisomerase	-
HA248_RS06265 (HA248_06255)	-	1226633..1227676 (-)	1044	WP_001812710.1	TIGR00341 family protein	-
HA248_RS11745	-	1228254..1228376 (+)	123	WP_001814242.1	hypothetical protein	-
HA248_RS06270 (HA248_06260)	dprA/cilB/dalA	1228560..1229408 (-)	849	WP_000705325.1	DNA-processing protein DprA	Machinery gene
HA248_RS06275 (HA248_06265)	-	1229504..1230193 (-)	690	WP_033707849.1	CTP--phosphocholine cytidylyltransferase	-
HA248_RS06280 (HA248_06270)	-	1230205..1231083 (-)	879	WP_000837609.1	DMT family transporter	-
HA248_RS06285 (HA248_06275)	licA	1231073..1231942 (-)	870	WP_033705343.1	choline kinase LicA	-
HA248_RS06290 (HA248_06280)	-	1231959..1232981 (-)	1023	WP_000609885.1	ribitol-5-phosphate dehydrogenase	-
HA248_RS06295 (HA248_06285)	-	1232986..1233693 (-)	708	WP_033705342.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-

Sequence

Protein

• Length: 282 a.a.
• Molecular weight: 31164.81 Da
• Isoelectric Point: 5.2061

>NTDB_id=430539 HA248_RS06270 WP_000705325.1 1228560..1229408(-) (dprA/cilB/dalA) [Streptococcus pneumoniae strain PZ900701590]
MKITNYEIYKLKKSSLTNQQILKVLEYGENVDQELLLGDIADISGCRNPAVFMERYFQIDDAHLSKEFQKFPSFSILDDC
YPWDLSEIYDAPVLLFYKGNLDLLKFPKVAVVGSRACSKQGAKTVEKVIQGLENELVIVSGLAKGIDTAAHMAALQNGGK
TIAVIGTGLDVFYPKANKRLQDYIGNDHLVLSEYGPGEQPLKFHFPARNRIIAGLCRGVIVAEAKMRSGSLITCERAMEE
GRDVFAIPDSILDGLSDGCHHLIQEGAKLVTSGQDVLAEFEF

Nucleotide

• Length: 849 bp

>NTDB_id=430539 HA248_RS06270 WP_000705325.1 1228560..1229408(-) (dprA/cilB/dalA) [Streptococcus pneumoniae strain PZ900701590]
ATGAAAATCACAAACTATGAAATCTATAAGTTAAAAAAATCAAGTTTGACCAATCAACAGATTTTGAAAGTGCTAGAATA
CGGTGAAAATGTTGATCAGGAGCTTTTGTTGGGTGATATTGCAGATATATCAGGTTGCCGTAATCCAGCCGTTTTTATGG
AACGTTATTTTCAGATAGACGATGCGCATTTGTCGAAAGAGTTTCAAAAATTTCCATCTTTCTCTATTTTAGATGACTGT
TATCCTTGGGATTTGAGTGAAATATATGATGCGCCTGTACTTTTATTTTACAAGGGAAATCTTGACCTCCTGAAATTCCC
GAAGGTAGCGGTCGTGGGCAGTCGTGCTTGTAGCAAACAGGGAGCTAAGACAGTTGAAAAAGTCATTCAAGGCTTGGAAA
ATGAACTGGTTATTGTCAGTGGTCTGGCCAAGGGCATTGACACAGCAGCTCATATGGCAGCTCTTCAGAATGGCGGAAAA
ACCATTGCAGTGATTGGAACAGGACTGGATGTGTTTTATCCTAAAGCCAATAAACGCTTGCAAGACTACATCGGCAATGA
CCATCTGGTTCTAAGTGAATATGGACCTGGCGAACAACCTCTGAAATTTCATTTTCCTGCCCGTAATCGCATCATTGCTG
GACTTTGTCGTGGTGTGATTGTAGCAGAGGCTAAGATGCGTTCAGGTAGTCTCATTACGTGTGAGCGAGCAATGGAAGAA
GGACGCGATGTCTTTGCTATTCCTGATAGCATTTTAGATGGACTATCAGACGGTTGCCATCATTTGATTCAAGAAGGAGC
AAAATTGGTCACCAGTGGGCAAGATGTTCTTGCGGAATTTGAATTTTAA

Domains

Predicted by InterproScan.

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (3-64)

• DNA recombination-mediator protein A (DNA_processg_A) (75-271)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	98.936	100	0.989
dprA/cilB/dalA	Streptococcus pneumoniae D39	98.936	100	0.989
dprA/cilB/dalA	Streptococcus pneumoniae R6	98.936	100	0.989
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	98.936	100	0.989
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	97.518	100	0.975
dprA/cilB/dalA	Streptococcus mitis SK321	96.809	100	0.968
dprA	Streptococcus mutans UA159	62.5	99.291	0.621
dprA	Lactococcus lactis subsp. cremoris KW2	54.643	99.291	0.543
dprA	Staphylococcus aureus N315	37.102	100	0.372