Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD2   Type   Regulator
Locus tag   HBA50_RS00045 Genome accession   NZ_CP050133
Coordinates   6251..7576 (+) Length   441 a.a.
NCBI ID   WP_045499899.1    Uniprot ID   A0A0F2CJX2
Organism   Streptococcus cristatus ATCC 51100     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 1251..12576
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HBA50_RS00015 (HBA50_00015) dnaA 1557..2912 (-) 1356 WP_045499883.1 chromosomal replication initiator protein DnaA -
  HBA50_RS00020 (HBA50_00020) spo0J 3125..3886 (-) 762 WP_045499887.1 ParB/RepB/Spo0J family partition protein Regulator
  HBA50_RS00025 (HBA50_00025) htrA 3949..5127 (-) 1179 WP_045499890.1 S1C family serine protease Regulator
  HBA50_RS00030 (HBA50_00030) rlmH 5330..5809 (+) 480 WP_045499893.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  HBA50_RS00040 (HBA50_00040) comC 6103..6228 (+) 126 WP_045499896.1 ComC/BlpC family leader-containing pheromone/bacteriocin Regulator
  HBA50_RS00045 (HBA50_00045) comD/comD2 6251..7576 (+) 1326 WP_045499899.1 GHKL domain-containing protein Regulator
  HBA50_RS00050 (HBA50_00050) comE/comE2 7573..8316 (+) 744 WP_045499902.1 competence system response regulator transcription factor ComE Regulator
  HBA50_RS00065 (HBA50_00065) - 8683..10077 (+) 1395 WP_166492625.1 IS1182 family transposase -
  HBA50_RS00070 (HBA50_00070) sdaAA 10172..11044 (-) 873 WP_045499908.1 L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha -
  HBA50_RS00075 (HBA50_00075) sdaAB 11053..11724 (-) 672 WP_045499905.1 L-serine ammonia-lyase, iron-sulfur-dependent subunit beta -

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 52276.02 Da        Isoelectric Point: 6.0954

>NTDB_id=430182 HBA50_RS00045 WP_045499899.1 6251..7576(+) (comD/comD2) [Streptococcus cristatus ATCC 51100]
MILNFILWFICELIEIFAIVKIYKKVESKVKSRFYFICLCIFTVIIAPLASLINLLLYYIILMVQPFLFYAYFYKKEKLP
NYLSLFLSFFLYLATQASSTFFSVIISSITGDQFVKSNWAIFYITINSISVLFMLKSIDYFEFQLRDFKDSSFKKTVQKT
NIYYFLTILILNVSHWLSEDDHFNSFSSMLATICFLIFMTTLFYLKAIREKYEKEEEIRQRELEQLQLQQYTDEIVSLYN
EIRGFRHDYAGMLTSFQTAINTQDIKEIEKIYQEVLVDANLKLRSDKYTYFDLNNVGDSALRSVMTETLFKAREHQIDLT
FEVKDPVEKLPIKLLDVVRMASILLNNAVEGAIESYEKMIHVTLVQLDTEIIFVVKNSRKQRKLDLEEIYEPEFSTKGYR
RGLGLNNLKEILENYEYIMLDTEISKYDFTQVLTIKRRNSL

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=430182 HBA50_RS00045 WP_045499899.1 6251..7576(+) (comD/comD2) [Streptococcus cristatus ATCC 51100]
ATGATATTAAACTTCATTTTATGGTTTATATGTGAATTAATAGAAATTTTTGCAATTGTAAAAATATATAAAAAAGTAGA
GAGTAAAGTAAAATCTAGATTTTACTTTATTTGTCTTTGTATTTTTACAGTTATTATTGCTCCTTTAGCATCTCTGATTA
ATTTATTACTCTATTACATCATCTTAATGGTGCAACCTTTCCTTTTTTATGCTTATTTTTATAAGAAAGAAAAGTTGCCT
AATTATCTTTCTTTATTTTTATCTTTTTTCCTTTATTTAGCAACTCAGGCTTCGTCTACCTTTTTTTCAGTTATTATTTC
ATCTATTACAGGGGATCAATTTGTAAAAAGTAATTGGGCTATCTTTTATATCACGATAAATAGTATCTCTGTTTTGTTTA
TGCTAAAATCCATTGATTATTTTGAATTTCAACTGAGAGATTTTAAAGACTCTTCCTTTAAAAAGACAGTTCAAAAGACT
AATATTTATTATTTTCTAACGATTCTCATATTGAATGTTTCGCATTGGTTAAGTGAAGACGATCATTTTAATAGTTTTAG
CAGTATGCTAGCGACTATTTGTTTCTTGATCTTTATGACGACTCTTTTCTATTTGAAGGCAATTCGGGAAAAGTATGAAA
AAGAAGAGGAGATTCGACAAAGAGAATTGGAACAGTTGCAGCTGCAGCAGTATACAGATGAAATTGTCTCTCTCTATAAT
GAAATTCGTGGTTTCCGTCATGATTATGCTGGCATGCTGACCAGCTTTCAGACGGCCATCAATACTCAAGATATCAAGGA
AATTGAAAAAATATATCAAGAAGTTTTAGTTGATGCAAATTTAAAATTACGCTCGGATAAATACACTTATTTTGATTTGA
ACAATGTTGGTGACTCAGCTCTCCGAAGCGTTATGACGGAGACTTTATTCAAAGCGCGTGAGCACCAGATTGATTTGACA
TTCGAAGTCAAAGATCCTGTTGAGAAATTACCGATTAAGCTATTAGATGTGGTAAGAATGGCTAGTATATTGCTAAACAA
TGCTGTTGAAGGCGCAATCGAAAGCTATGAAAAAATGATTCATGTGACTTTAGTTCAACTCGATACGGAGATTATTTTTG
TTGTAAAAAATTCCCGCAAGCAAAGAAAATTAGATTTAGAAGAAATTTATGAACCAGAGTTCTCAACGAAAGGTTATCGA
AGAGGCCTAGGTTTAAATAATCTGAAAGAAATTTTAGAGAATTATGAATATATCATGCTAGATACAGAAATAAGTAAGTA
TGATTTCACCCAAGTATTAACAATTAAAAGAAGGAATAGTTTATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(333-435)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0F2CJX2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD2 Streptococcus gordonii strain NCTC7865

51.106

100

0.524
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

56.331

87.755

0.494
  comD Streptococcus mitis NCTC 12261

42.155

96.825

0.408
  comD Streptococcus mitis SK321

43.883

85.261

0.374
  comD/comD2 Streptococcus pneumoniae TIGR4

45.954

78.458

0.361