Detailed information NTG0426981

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: G8B40_RS05105
• Genome accession: NZ_CP049692
• Coordinates: 982262..983098 (+)
• Length: 278 a.a.
• NCBI ID: WP_011017772.1
• Uniprot ID: A0A660A2Q7
• Organism: Streptococcus pyogenes strain ABC157
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 977262..988098

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
G8B40_RS05075 (G8B40_05110)	-	977750..978184 (+)	435	WP_021299262.1	hypothetical protein	-
G8B40_RS05080 (G8B40_05115)	-	978234..979145 (-)	912	WP_219243819.1	diacylglycerol kinase family protein	-
G8B40_RS05085 (G8B40_05120)	-	979262..979912 (-)	651	WP_219243821.1	hemolysin III family protein	-
G8B40_RS05090 (G8B40_05125)	-	979909..980349 (-)	441	WP_011017769.1	DUF1836 domain-containing protein	-
G8B40_RS05095 (G8B40_05130)	ylqF	980568..981416 (+)	849	WP_011017770.1	ribosome biogenesis GTPase YlqF	-
G8B40_RS05100 (G8B40_05135)	-	981406..982197 (+)	792	WP_011017771.1	ribonuclease HII	-
G8B40_RS05105 (G8B40_05140)	dprA	982262..983098 (+)	837	WP_011017772.1	DNA-processing protein DprA	Machinery gene
G8B40_RS05110 (G8B40_05145)	topA	983205..985334 (+)	2130	WP_011528644.1	type I DNA topoisomerase	-
G8B40_RS05115 (G8B40_05150)	-	985410..986294 (-)	885	Protein_968	LysR family transcriptional regulator	-
G8B40_RS05120 (G8B40_05155)	-	986307..986873 (+)	567	Protein_969	PTS sugar transporter subunit IIC	-
G8B40_RS05125 (G8B40_05160)	-	986888..987880 (+)	993	WP_021299266.1	D-lactate dehydrogenase	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 31088.08 Da
• Isoelectric Point: 9.0513

>NTDB_id=426981 G8B40_RS05105 WP_011017772.1 982262..983098(+) (dprA) [Streptococcus pyogenes strain ABC157]
MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPREEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGATCVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=426981 G8B40_RS05105 WP_011017772.1 982262..983098(+) (dprA) [Streptococcus pyogenes strain ABC157]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCCGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTTGGCTCCAGACGCTCAAGCGATACCGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAACCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACCATC
GCTATTATTGGAACAGGGTTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAAGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAACATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A660A2Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.626	100	0.676
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis SK321	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	60.072	100	0.601
dprA	Lactococcus lactis subsp. cremoris KW2	57.194	100	0.572
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367