Detailed information NTG0426814

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: G8B43_RS04815
• Genome accession: NZ_CP049689
• Coordinates: 940513..941349 (-)
• Length: 278 a.a.
• NCBI ID: WP_011017772.1
• Uniprot ID: A0A660A2Q7
• Organism: Streptococcus pyogenes strain ABC221
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 935513..946349

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
G8B43_RS04795 (G8B43_04810)	-	935731..936723 (-)	993	WP_021299266.1	D-lactate dehydrogenase	-
G8B43_RS04800 (G8B43_04815)	-	936738..937304 (-)	567	Protein_888	PTS sugar transporter subunit IIC	-
G8B43_RS04805 (G8B43_04820)	-	937317..938201 (+)	885	Protein_889	LysR family transcriptional regulator	-
G8B43_RS04810 (G8B43_04825)	topA	938277..940406 (-)	2130	WP_011528644.1	type I DNA topoisomerase	-
G8B43_RS04815 (G8B43_04830)	dprA	940513..941349 (-)	837	WP_011017772.1	DNA-processing protein DprA	Machinery gene
G8B43_RS04820 (G8B43_04835)	-	941414..942205 (-)	792	WP_011017771.1	ribonuclease HII	-
G8B43_RS04825 (G8B43_04840)	ylqF	942195..943043 (-)	849	WP_011017770.1	ribosome biogenesis GTPase YlqF	-
G8B43_RS04830 (G8B43_04845)	-	943262..943702 (+)	441	WP_011017769.1	DUF1836 domain-containing protein	-
G8B43_RS04835 (G8B43_04850)	-	943699..944349 (+)	651	WP_002984629.1	hemolysin III family protein	-
G8B43_RS04840 (G8B43_04855)	-	944466..945377 (+)	912	WP_011528643.1	diacylglycerol kinase family protein	-
G8B43_RS04845 (G8B43_04860)	-	945427..945861 (-)	435	WP_165618756.1	apolipoprotein A1/A4/E family protein	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 31088.08 Da
• Isoelectric Point: 9.0513

>NTDB_id=426814 G8B43_RS04815 WP_011017772.1 940513..941349(-) (dprA) [Streptococcus pyogenes strain ABC221]
MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPREEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGATCVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=426814 G8B43_RS04815 WP_011017772.1 940513..941349(-) (dprA) [Streptococcus pyogenes strain ABC221]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCCGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTTGGCTCCAGACGCTCAAGCGATACCGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAACCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACCATC
GCTATTATTGGAACAGGGTTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAAGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAACATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A660A2Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.626	100	0.676
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis SK321	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	60.072	100	0.601
dprA	Lactococcus lactis subsp. cremoris KW2	57.194	100	0.572
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367