Detailed information NTG0426757

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: G8B44_RS04505
• Genome accession: NZ_CP049688
• Coordinates: 899130..899966 (-)
• Length: 278 a.a.
• NCBI ID: WP_011017772.1
• Uniprot ID: A0A660A2Q7
• Organism: Streptococcus pyogenes strain ABC245
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 894130..904966

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
G8B44_RS04485 (G8B44_04500)	-	894348..895340 (-)	993	WP_021299266.1	D-lactate dehydrogenase	-
G8B44_RS04490 (G8B44_04505)	-	895355..895921 (-)	567	Protein_826	PTS sugar transporter subunit IIC	-
G8B44_RS04495 (G8B44_04510)	-	895934..896818 (+)	885	Protein_827	LysR family transcriptional regulator	-
G8B44_RS04500 (G8B44_04515)	topA	896894..899023 (-)	2130	WP_011528644.1	type I DNA topoisomerase	-
G8B44_RS04505 (G8B44_04520)	dprA	899130..899966 (-)	837	WP_011017772.1	DNA-processing protein DprA	Machinery gene
G8B44_RS04510 (G8B44_04525)	-	900031..900822 (-)	792	WP_011017771.1	ribonuclease HII	-
G8B44_RS04515 (G8B44_04530)	ylqF	900812..901660 (-)	849	WP_011017770.1	ribosome biogenesis GTPase YlqF	-
G8B44_RS04520 (G8B44_04535)	-	901879..902319 (+)	441	WP_219233144.1	DUF1836 domain-containing protein	-
G8B44_RS04525 (G8B44_04540)	-	902316..902966 (+)	651	WP_002984629.1	hemolysin III family protein	-
G8B44_RS04530 (G8B44_04545)	-	903083..903994 (+)	912	WP_011528643.1	diacylglycerol kinase family protein	-
G8B44_RS04535 (G8B44_04550)	-	904044..904478 (-)	435	WP_021299262.1	hypothetical protein	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 31088.08 Da
• Isoelectric Point: 9.0513

>NTDB_id=426757 G8B44_RS04505 WP_011017772.1 899130..899966(-) (dprA) [Streptococcus pyogenes strain ABC245]
MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPREEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGATCVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=426757 G8B44_RS04505 WP_011017772.1 899130..899966(-) (dprA) [Streptococcus pyogenes strain ABC245]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCCGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTTGGCTCCAGACGCTCAAGCGATACCGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAACCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACCATC
GCTATTATTGGAACAGGGTTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAAGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAACATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A660A2Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.626	100	0.676
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis SK321	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	60.072	100	0.601
dprA	Lactococcus lactis subsp. cremoris KW2	57.194	100	0.572
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367