Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   ST64987_RS03885 Genome accession   NZ_CP049053
Coordinates   731065..731739 (+) Length   224 a.a.
NCBI ID   WP_113870373.1    Uniprot ID   -
Organism   Streptococcus thermophilus strain ST64987     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 726065..736739
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ST64987_RS03865 (ST64987_0722) - 727193..727765 (-) 573 WP_011681047.1 ECF transporter S component -
  ST64987_RS03870 (ST64987_0723) coaC 727793..728338 (-) 546 WP_014608202.1 phosphopantothenoylcysteine decarboxylase -
  ST64987_RS03875 (ST64987_0724) - 728331..729014 (-) 684 WP_002948206.1 phosphopantothenate--cysteine ligase -
  ST64987_RS03880 (ST64987_0725) - 729208..730878 (+) 1671 WP_167401476.1 formate--tetrahydrofolate ligase -
  ST64987_RS03885 (ST64987_0726) ciaR 731065..731739 (+) 675 WP_113870373.1 response regulator transcription factor Regulator
  ST64987_RS10165 - 731729..733148 (+) 1420 Protein_699 sensor histidine kinase -
  ST64987_RS03910 - 733249..734819 (+) 1571 WP_167401477.1 IS3-like element ISSth1b family transposase -
  ST64987_RS03915 (ST64987_0732) - 735010..736221 (+) 1212 WP_167401478.1 ISL3 family transposase -
  ST64987_RS03920 (ST64987_0733) - 736344..736580 (+) 237 Protein_702 ABC transporter permease -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25418.05 Da        Isoelectric Point: 4.2405

>NTDB_id=424474 ST64987_RS03885 WP_113870373.1 731065..731739(+) (ciaR) [Streptococcus thermophilus strain ST64987]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLKELREQGITTPILIMTA
KESLDDKGHGFELGADDYLTKPFYLKELKMRIEALLKRSGKFDQNTFSFGDVCVNLSTNSTYVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTNVSVVEVYVSKIRKKLKGTDFATNLQTLRSVGYILKNAD

Nucleotide


Download         Length: 675 bp        

>NTDB_id=424474 ST64987_RS03885 WP_113870373.1 731065..731739(+) (ciaR) [Streptococcus thermophilus strain ST64987]
ATGATTAAAATTTTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCGGATGT
GATGCAAGTATTTGATGGAGATGAAGGTCTTTACGAAGCTGAAAGTGGTGTTTATGATTTGATTCTTTTGGACTTAATGT
TACCTGAAAAAGATGGTTTTACAGTTCTTAAAGAATTGCGTGAACAAGGAATAACGACTCCTATTCTTATCATGACTGCT
AAGGAAAGTCTAGACGATAAGGGGCATGGCTTCGAACTCGGAGCTGATGATTATCTAACCAAGCCTTTCTATTTAAAAGA
ATTGAAGATGCGTATTGAGGCACTTTTGAAACGTTCTGGTAAATTTGATCAAAATACTTTTTCTTTTGGAGATGTTTGTG
TCAACCTTTCTACAAATTCAACTTATGTGGGTGATAAAGAAGTAGAACTTCTTGGTAAAGAATTTGATTTATTAGTCTAC
TTCCTACAAAATCAAAACGTTATTTTGCCCAAGTCGCAAATCTTTGATCGTCTTTGGGGATTTGATAGTGATACCAATGT
CTCTGTTGTTGAAGTTTATGTTTCGAAAATTCGTAAGAAACTTAAGGGGACTGATTTTGCTACCAACCTACAAACCTTAA
GAAGTGTGGGGTATATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

86.099

99.554

0.857
  ciaR Streptococcus pneumoniae D39

86.099

99.554

0.857
  ciaR Streptococcus pneumoniae R6

86.099

99.554

0.857
  ciaR Streptococcus pneumoniae TIGR4

86.099

99.554

0.857
  ciaR Streptococcus mutans UA159

84.375

100

0.844
  vicR Streptococcus mutans UA159

35.593

100

0.375
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.333

100

0.375
  micA Streptococcus pneumoniae Cp1015

35.169

100

0.371