Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SPPN_RS04030 Genome accession   NC_015875
Coordinates   775419..776093 (+) Length   224 a.a.
NCBI ID   WP_000590626.1    Uniprot ID   A0A0T8TLG1
Organism   Streptococcus pseudopneumoniae IS7493     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 770419..781093
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPPN_RS04010 (SPPN_04070) - 770587..771315 (+) 729 WP_000418690.1 GNAT family N-acetyltransferase -
  SPPN_RS04015 (SPPN_04075) - 771357..772226 (+) 870 WP_001245827.1 putative PEP-binding protein -
  SPPN_RS04020 (SPPN_04080) - 772201..772641 (+) 441 WP_000188832.1 ASCH domain-containing protein -
  SPPN_RS04025 (SPPN_04085) - 772764..775310 (+) 2547 WP_001149128.1 M1 family metallopeptidase -
  SPPN_RS04030 (SPPN_04090) ciaR 775419..776093 (+) 675 WP_000590626.1 two-component system response regulator CiaR Regulator
  SPPN_RS04035 (SPPN_04095) ciaH 776083..777417 (+) 1335 WP_000491804.1 two-component system sensor histidine kinase CiaH Regulator
  SPPN_RS04040 (SPPN_04100) - 777587..777874 (-) 288 WP_001111517.1 DUF3270 domain-containing protein -
  SPPN_RS04045 (SPPN_04105) - 778014..778943 (+) 930 WP_014017228.1 peptidase U32 family protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25467.28 Da        Isoelectric Point: 4.2854

>NTDB_id=41991 SPPN_RS04030 WP_000590626.1 775419..776093(+) (ciaR) [Streptococcus pseudopneumoniae IS7493]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDILINLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFADNLQTLRSVGYILKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=41991 SPPN_RS04030 WP_000590626.1 775419..776093(+) (ciaR) [Streptococcus pseudopneumoniae IS7493]
ATGATAAAAATCTTATTGGTTGAGGATGACCTAGGTCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCGGATGT
TATGCAGGTATTTGATGGTGAAGAAGGTCTCTACGAAGCTGAAAGTGGTGTCTATGACTTGATTTTGCTCGATTTGATGT
TGCCAGAAAAAAATGGTTTCCAAGTCTTAAAAGAATTGCGTGAAAAGGGAATTACGACACCAGTTCTGATCATGACCGCC
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTGGGAGCGGATGATTATCTGACCAAGCCTTTCTACCTAGAAGA
ACTCAAAATGCGGATTCAGGCCCTTCTCAAACGTTCAGGCAAGTTTAATGAAAATACGCTATCTTATGGAGATATTCTCA
TCAATTTATCAACAAATACCGTTAAGGTTGAAGATACTCCAGTCGAATTGCTGGGGAAAGAGTTCGATTTACTAGTTTAT
TTCCTTCAAAATCAAAATGTTATTTTGCCTAAGACGCAGATTTTTGATCGTCTATGGGGATTTGATAGTGACACAACGAT
TTCAGTTGTCGAAGTTTATGTTTCAAAAGTCCGTAAGAAATTAAAAGGAACCACTTTTGCAGATAATTTGCAAACCTTGC
GCAGTGTTGGGTATATTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0T8TLG1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

97.321

100

0.973
  ciaR Streptococcus pneumoniae D39

97.321

100

0.973
  ciaR Streptococcus pneumoniae R6

97.321

100

0.973
  ciaR Streptococcus pneumoniae TIGR4

97.321

100

0.973
  ciaR Streptococcus mutans UA159

87.946

100

0.879
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.611

100

0.379
  vicR Streptococcus mutans UA159

36.052

100

0.375

Multiple sequence alignment