Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   M594_RS06400 Genome accession   NZ_CP047883
Coordinates   1300116..1300790 (-) Length   224 a.a.
NCBI ID   WP_049542984.1    Uniprot ID   -
Organism   Streptococcus mitis strain S022-V3-A4     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1295116..1305790
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M594_RS06375 (M594_06395) - 1295276..1296205 (-) 930 WP_173876273.1 peptidase U32 family protein -
  M594_RS06380 (M594_06400) - 1296329..1297009 (-) 681 WP_173876274.1 ABC transporter ATP-binding protein -
  M594_RS06385 (M594_06405) - 1297023..1298078 (-) 1056 WP_173876275.1 ABC transporter permease -
  M594_RS06390 (M594_06410) - 1298437..1298721 (+) 285 WP_136937644.1 DUF3270 domain-containing protein -
  M594_RS06395 (M594_06415) ciaH 1298789..1300126 (-) 1338 WP_173876276.1 sensor histidine kinase Regulator
  M594_RS06400 (M594_06420) ciaR 1300116..1300790 (-) 675 WP_049542984.1 two-component system response regulator CiaR Regulator
  M594_RS06405 (M594_06425) - 1300899..1303445 (-) 2547 WP_173876277.1 M1 family metallopeptidase -
  M594_RS06410 (M594_06430) - 1303568..1304008 (-) 441 WP_173876278.1 ASCH domain-containing protein -
  M594_RS06415 (M594_06435) - 1304039..1304737 (-) 699 WP_173876279.1 3-oxoacyl-ACP reductase -
  M594_RS06420 (M594_06440) - 1304730..1304966 (-) 237 WP_000141924.1 DUF2829 domain-containing protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25452.27 Da        Isoelectric Point: 4.3283

>NTDB_id=418261 M594_RS06400 WP_049542984.1 1300116..1300790(-) (ciaR) [Streptococcus mitis strain S022-V3-A4]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENSLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYILKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=418261 M594_RS06400 WP_049542984.1 1300116..1300790(-) (ciaR) [Streptococcus mitis strain S022-V3-A4]
ATGATAAAAATCTTATTAGTTGAGGATGACCTAGGCCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCGGATGT
TATGCAGGTATTTGATGGGGAAGAAGGTCTCTACGAAGCTGAGAGTGGAGTCTATGATTTGATTTTGCTCGATTTGATGT
TACCTGAAAAAAATGGCTTCCAAGTCTTGAAAGAATTGCGTGAAAAGGGGATTACGACTCCAGTTCTGATCATGACTGCC
AAGGAAAGTTTGGATGATAAGGGACATGGATTTGAACTGGGAGCGGATGATTATCTGACTAAACCTTTCTACCTAGAAGA
ACTCAAAATGCGGATTCAAGCCCTTCTCAAACGTTCAGGTAAATTTAATGAAAACAGCTTGACTTATGGAAATATTGTGG
TTAATTTGTCAACCAATACCGTTAAAGTCGAAGATACTCCTGTCGAATTGTTGGGGAAAGAGTTCGATTTATTAGTTTAT
TTCCTTCAAAATCAAAATGTTATTTTGCCCAAGACTCAGATTTTTGATCGTCTATGGGGATTTGATAGTGACACAACGAT
TTCAGTTGTCGAAGTCTATGTTTCAAAAGTCCGTAAGAAATTAAAAGGAACCACTTTTGCAGAGAATTTGCAAACCTTGC
GCAGTGTTGGGTATATTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae TIGR4

99.107

100

0.991
  ciaR Streptococcus pneumoniae D39

99.107

100

0.991
  ciaR Streptococcus pneumoniae R6

99.107

100

0.991
  ciaR Streptococcus pneumoniae Rx1

99.107

100

0.991
  ciaR Streptococcus mutans UA159

88.839

100

0.888
  vicR Streptococcus mutans UA159

35.622

100

0.371
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.444

100

0.366

Multiple sequence alignment