Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   M594_RS06395 Genome accession   NZ_CP047883
Coordinates   1298789..1300126 (-) Length   445 a.a.
NCBI ID   WP_173876276.1    Uniprot ID   A0A6M9F6N9
Organism   Streptococcus mitis strain S022-V3-A4     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1293789..1305126
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M594_RS06370 (M594_06390) rpiA 1294488..1295171 (-) 684 WP_173876272.1 ribose-5-phosphate isomerase RpiA -
  M594_RS06375 (M594_06395) - 1295276..1296205 (-) 930 WP_173876273.1 peptidase U32 family protein -
  M594_RS06380 (M594_06400) - 1296329..1297009 (-) 681 WP_173876274.1 ABC transporter ATP-binding protein -
  M594_RS06385 (M594_06405) - 1297023..1298078 (-) 1056 WP_173876275.1 ABC transporter permease -
  M594_RS06390 (M594_06410) - 1298437..1298721 (+) 285 WP_136937644.1 DUF3270 domain-containing protein -
  M594_RS06395 (M594_06415) ciaH 1298789..1300126 (-) 1338 WP_173876276.1 sensor histidine kinase Regulator
  M594_RS06400 (M594_06420) ciaR 1300116..1300790 (-) 675 WP_049542984.1 two-component system response regulator CiaR Regulator
  M594_RS06405 (M594_06425) - 1300899..1303445 (-) 2547 WP_173876277.1 M1 family metallopeptidase -
  M594_RS06410 (M594_06430) - 1303568..1304008 (-) 441 WP_173876278.1 ASCH domain-containing protein -
  M594_RS06415 (M594_06435) - 1304039..1304737 (-) 699 WP_173876279.1 3-oxoacyl-ACP reductase -
  M594_RS06420 (M594_06440) - 1304730..1304966 (-) 237 WP_000141924.1 DUF2829 domain-containing protein -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 50904.55 Da        Isoelectric Point: 9.3606

>NTDB_id=418260 M594_RS06395 WP_173876276.1 1298789..1300126(-) (ciaH) [Streptococcus mitis strain S022-V3-A4]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAVNRATEEIKDLENAA
TDSSKTEVKPNVSSNTEVILFDKNFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRMILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVIVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
NLFRKPEATIMESSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPEIAEVSPQFFKTTFTNYGLIASENDRVFESENRI
YRPIMTDQLLLKQLMTILFDNAIKYTEEDGKIEFLVHCTDRHLYLTVSDNGIGISATDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDSLRGTITVKDNKPRGTIFEVKIAIQSPSKRKNR

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=418260 M594_RS06395 WP_173876276.1 1298789..1300126(-) (ciaH) [Streptococcus mitis strain S022-V3-A4]
ATGTTCAGTAAACTAAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGCAACTTTGGTGTCTTCACTCTGAT
TTTCTCCACTATGACCTTGATTATATTGCAGGTCATGCATTCGAGTCTCTATACTTCGGTGGATGATAAGCTTCATGGAC
TGAGTGAAAATCCTCAGGCAGTTATTCAGCTGGCTGTAAATAGGGCAACAGAAGAGATTAAAGACTTAGAGAATGCCGCT
ACAGATTCTAGCAAGACTGAAGTAAAACCCAATGTCAGTTCCAACACAGAAGTCATTCTTTTTGATAAGAATTTTACCCA
GCTCCTTTCTGGAAACCGATTTTTGGGATTGGATAAGATTAAGTTAGAGAAAAAAGAACTAGGCCATATCTACCAGATTC
AAGTTTTTAATAGCTATGGACAAGAAGAAATTTATCGCATGATTTTGATGGAAACGAATATCAGTTCGGTTTCAACCAAT
ATCAAGTATGCAGCTGTTTTGATTAATACCAGTCAGTTGGAGCAAGCCAGTCAAAAGCATGAGCAATTGATTGTGATCGT
GATGGCTAGTTTCTGGATTCTGTCTTTGCTCGCCAGTCTCTATCTAGCTAGGGTCAGTGTTCGTCCTCTGCTTGAGAGCA
TGCAGAAGCAACAGTCCTTTGTGGAAAATGCTAGTCATGAATTGAGAACTCCTTTAGCAGTCTTGCAAAATCGTTTGGAG
AATTTGTTTAGAAAACCCGAAGCGACCATTATGGAGTCTAGTGAGAGTATCGCTTCCAGTCTTGAAGAAGTTCGAAATAT
GCGTTTTTTAACAACAAATCTTCTTAACTTAGCCCGCCGTGATGATGGAATAAAACCAGAAATAGCGGAAGTATCACCAC
AGTTCTTTAAAACGACCTTTACGAACTATGGCTTGATTGCTTCGGAAAATGACCGAGTCTTTGAATCTGAGAATAGAATT
TACCGTCCTATTATGACGGATCAGTTGCTTCTCAAGCAGTTAATGACAATCTTATTTGATAATGCAATAAAATATACAGA
AGAAGATGGAAAGATTGAGTTTCTTGTTCATTGTACAGATCGGCATCTTTATCTTACTGTATCTGATAATGGTATTGGTA
TTTCGGCTACAGATAAAAAGAAAATCTTTGATCGCTTCTATCGTGTTGATAAGGCAAGAACTCGTCAGAAAGGTGGTTTT
GGTTTGGGATTATCTTTGGCCAAGCAGATTGTTGATTCCTTAAGAGGAACGATTACAGTTAAGGATAATAAACCGAGAGG
AACGATTTTTGAAGTCAAGATTGCAATTCAATCTCCCTCGAAACGTAAGAATAGATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(217-283)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A6M9F6N9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

90.519

99.551

0.901
  ciaH Streptococcus pneumoniae D39

90.519

99.551

0.901
  ciaH Streptococcus pneumoniae R6

90.519

99.551

0.901
  ciaH Streptococcus pneumoniae TIGR4

90.519

99.551

0.901
  ciaH Streptococcus mutans UA159

55.069

97.528

0.537

Multiple sequence alignment