Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   M594_RS05835 Genome accession   NZ_CP047883
Coordinates   1181492..1182199 (-) Length   235 a.a.
NCBI ID   WP_000722072.1    Uniprot ID   A0A3R9LLL2
Organism   Streptococcus mitis strain S022-V3-A4     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1176492..1187199
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M594_RS05815 (M594_05830) - 1177126..1178844 (+) 1719 WP_000121686.1 phospho-sugar mutase -
  M594_RS05820 (M594_05835) - 1178956..1179303 (+) 348 WP_000434637.1 thioredoxin -
  M594_RS05825 (M594_05840) vicX 1179339..1180148 (-) 810 WP_000004965.1 MBL fold metallo-hydrolase Regulator
  M594_RS05830 (M594_05845) micB 1180150..1181499 (-) 1350 WP_173876222.1 cell wall metabolism sensor histidine kinase VicK Regulator
  M594_RS05835 (M594_05850) micA 1181492..1182199 (-) 708 WP_000722072.1 response regulator YycF Regulator
  M594_RS05840 (M594_05855) mutY 1182255..1183430 (-) 1176 WP_173876223.1 A/G-specific adenine glycosylase -
  M594_RS05845 (M594_05860) pta 1183619..1184593 (-) 975 WP_000451571.1 phosphate acetyltransferase -
  M594_RS05850 (M594_05865) - 1184637..1185533 (-) 897 WP_173876224.1 RluA family pseudouridine synthase -
  M594_RS05855 (M594_05870) - 1185530..1186348 (-) 819 WP_000799056.1 NAD kinase -
  M594_RS05860 (M594_05875) - 1186332..1187003 (-) 672 WP_000171682.1 GTP pyrophosphokinase -

Sequence

Protein


Download         Length: 235 a.a.        Molecular weight: 27107.90 Da        Isoelectric Point: 4.6177

>NTDB_id=418257 M594_RS05835 WP_000722072.1 1181492..1182199(-) (micA) [Streptococcus mitis strain S022-V3-A4]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPIIMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRTDLVSVDNQESDEKKTQPLQIGDLEIVPDAYVAKKYGEELDL
THREFELLYHLASHIGQVITREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMRNND

Nucleotide


Download         Length: 708 bp        

>NTDB_id=418257 M594_RS05835 WP_000722072.1 1181492..1182199(-) (micA) [Streptococcus mitis strain S022-V3-A4]
ATGAAAAAAATATTAATTGTAGATGATGAAAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
GGTTGTAACTGCTTTTAATGGTCGTGAAGCACTAGAACAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCCGAAATTGATGGTTTAGAAGTTGCAAAGACTATTCGTAAGACGAGTAGTGTACCTATTATCATGCTGTCAGCT
AAAGACAGTGAGTTTGATAAGGTTATCGGTTTAGAGCTTGGAGCGGATGACTATGTAACCAAACCCTTCTCAAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTTCGTCGTACGGATTTGGTTTCTGTAGATAATCAAGAATCAGATGAAAAGAAAA
CCCAACCCTTGCAAATTGGGGACTTGGAGATTGTACCAGATGCTTATGTAGCTAAAAAATACGGTGAAGAACTAGACTTA
ACCCACCGTGAATTTGAGCTTTTGTACCACTTGGCGTCTCATATTGGTCAAGTGATTACACGTGAACATTTGCTTGAAAC
GGTCTGGGGTTATGATTATTTCGGAGATGTTCGGACTGTTGACGTAACTATCAGACGTTTGCGTGAGAAGATTGAAGATA
CACCTAGTCGTCCAGAGTATATCCTAACACGTCGTGGTGTTGGTTATTATATGAGAAATAATGATTGA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(155-230)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A3R9LLL2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

94.017

99.574

0.936
  vicR Streptococcus mutans UA159

77.447

100

0.774
  covR Streptococcus salivarius strain HSISS4

44.589

98.298

0.438
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.723

98.298

0.43
  scnR Streptococcus mutans UA159

38.034

99.574

0.379

Multiple sequence alignment