Detailed information    

insolico Bioinformatically predicted

Overview

Name   comB   Type   Regulator
Locus tag   M594_RS00200 Genome accession   NZ_CP047883
Coordinates   37144..38493 (+) Length   449 a.a.
NCBI ID   WP_173875642.1    Uniprot ID   A0A6M9F7M8
Organism   Streptococcus mitis strain S022-V3-A4     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 32144..43493
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M594_RS00175 (M594_00175) - 32639..32875 (+) 237 WP_000136444.1 acyl carrier protein -
  M594_RS00180 (M594_00180) - 33320..33496 (+) 177 WP_000180828.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  M594_RS00185 (M594_00185) - 33728..33898 (+) 171 WP_173875640.1 H354_08695 family bacteriocin-like peptide -
  M594_RS00190 (M594_00190) - 33938..34117 (+) 180 WP_000846988.1 hypothetical protein -
  M594_RS10055 - 34525..34713 (+) 189 WP_254597155.1 hypothetical protein -
  M594_RS00195 (M594_00195) comA 35023..37131 (+) 2109 WP_173875641.1 peptide cleavage/export ABC transporter ComA Regulator
  M594_RS00200 (M594_00200) comB 37144..38493 (+) 1350 WP_173875642.1 competence pheromone export protein ComB Regulator
  M594_RS00205 (M594_00205) purC 38663..39370 (+) 708 WP_173875643.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  M594_RS00210 (M594_00210) - 39437..43162 (+) 3726 WP_173875644.1 phosphoribosylformylglycinamidine synthase -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 49757.67 Da        Isoelectric Point: 5.4073

>NTDB_id=418223 M594_RS00200 WP_173875642.1 37144..38493(+) (comB) [Streptococcus mitis strain S022-V3-A4]
MKPEFLESAEFYNRRYHNFSSRVVVPMSLLLVFLLGFATVAEKEMSLSTRATVEPSRILANIQSTSNNRILVNHLEENKL
VKKGELLVQYQEGAEGVQAEAYASQLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQN
ETIASQNAAASQTQTEIGTLISQTEAKIRDYQTAKSAIETGASLASENLAYSLYQSYKSQGEENPQSKAQAVAQVEAQLS
QLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKVGQELTLLDQKILEAESGKKVQGNLLEKGKITASEDGVLH
LNPETSDSTMVAEGALLAQLYPSLEKEGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAKNQLFLDSTITSIDATATKTEK
GNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=418223 M594_RS00200 WP_173875642.1 37144..38493(+) (comB) [Streptococcus mitis strain S022-V3-A4]
ATGAAACCAGAATTTTTAGAAAGTGCGGAGTTTTATAATCGACGTTACCATAATTTTTCCAGTCGGGTGGTTGTACCCAT
GTCCCTTCTGCTCGTGTTTTTGCTTGGCTTTGCAACTGTTGCAGAGAAGGAGATGAGTTTGTCCACCAGAGCGACTGTTG
AGCCTAGTCGTATCCTGGCAAATATCCAGTCAACTAGCAACAATCGCATTCTTGTTAATCATTTGGAAGAAAATAAGCTG
GTTAAAAAGGGAGAACTGTTGGTTCAATATCAAGAAGGGGCAGAGGGTGTCCAAGCGGAGGCCTATGCTAGTCAGTTGGA
CATGCTCAAGGATCAAAAAAAGCAATTGGAGTATTTGCAGAAGAGCCTACAAGAAGGGGAGAACCACTTTCCAGAGGAGG
ATAAGTTTGGCTACCAAGCCACCTTTCGTGACTACATCAGCCAAGCAGGTAGTCTTAGGGCTAGTACATCGCAACAAAAT
GAGACCATCGCGTCCCAGAATGCAGCAGCTAGTCAAACCCAAACCGAAATCGGCACCCTCATCAGTCAAACAGAGGCTAA
AATTCGCGATTACCAGACAGCTAAGTCAGCTATTGAAACAGGTGCTTCCTTGGCCAGTGAGAATCTAGCCTACTCTCTCT
ACCAGTCCTACAAGTCTCAGGGCGAGGAAAATCCGCAATCTAAGGCACAAGCAGTTGCGCAGGTTGAAGCACAGCTTTCT
CAGTTAGAATCTAGTCTTGCTACTTACCGTGTCCAGTATGCAGGTTCAGGTACCCAGCAAGCCTATGCGTCAGGTTTAAG
CAGTCAATTGGAATCTCTTAAATCACAACACTTGGCTAAGGTTGGTCAGGAATTGACCCTTCTAGACCAGAAAATTTTGG
AGGCAGAATCGGGTAAGAAGGTTCAGGGAAATCTTTTAGAAAAGGGGAAAATTACGGCGAGTGAGGATGGGGTGCTTCAC
CTTAATCCTGAGACTAGTGATTCTACTATGGTAGCAGAAGGTGCCTTATTAGCTCAACTCTATCCGTCCTTGGAAAAAGA
AGGGAAAGCCAAACTCACAGCTTATCTTAGTTCAAAGGATGTAGCAAGGATCAAGGTCGGTGATTCTGTTCGTTATACTA
CGACTCATGATGCCAAGAATCAACTTTTCCTAGATTCTACTATTACAAGTATTGATGCGACAGCTACTAAGACTGAAAAA
GGGAATTTCTTTAAAATCGAGGCGGAGACTAATCTAACTTCGGAGCAGGCTGAAAAACTTCGGTACGGGGTGGAAGGTCG
CCTGCAGATGATTACGGGCAAGAAAAGTTACCTACGTTATTATTTAGATCAATTTTTGAACAAAGAGTAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A6M9F7M8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB Streptococcus mitis NCTC 12261

96.437

100

0.964
  comB Streptococcus mitis SK321

96.437

100

0.964
  comB Streptococcus pneumoniae TIGR4

95.768

100

0.958
  comB Streptococcus pneumoniae D39

95.546

100

0.955
  comB Streptococcus pneumoniae Rx1

95.546

100

0.955
  comB Streptococcus pneumoniae R6

95.546

100

0.955
  comB Streptococcus gordonii str. Challis substr. CH1

55.333

100

0.555

Multiple sequence alignment