Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   M594_RS00195 Genome accession   NZ_CP047883
Coordinates   35023..37131 (+) Length   702 a.a.
NCBI ID   WP_173875641.1    Uniprot ID   -
Organism   Streptococcus mitis strain S022-V3-A4     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 30023..42131
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M594_RS00165 (M594_00165) recO 30874..31644 (+) 771 WP_173875638.1 DNA repair protein RecO -
  M594_RS00170 (M594_00170) plsX 31641..32633 (+) 993 WP_173875639.1 phosphate acyltransferase PlsX -
  M594_RS00175 (M594_00175) - 32639..32875 (+) 237 WP_000136444.1 acyl carrier protein -
  M594_RS00180 (M594_00180) - 33320..33496 (+) 177 WP_000180828.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  M594_RS00185 (M594_00185) - 33728..33898 (+) 171 WP_173875640.1 H354_08695 family bacteriocin-like peptide -
  M594_RS00190 (M594_00190) - 33938..34117 (+) 180 WP_000846988.1 hypothetical protein -
  M594_RS10055 - 34525..34713 (+) 189 WP_254597155.1 hypothetical protein -
  M594_RS00195 (M594_00195) comA 35023..37131 (+) 2109 WP_173875641.1 peptide cleavage/export ABC transporter ComA Regulator
  M594_RS00200 (M594_00200) comB 37144..38493 (+) 1350 WP_173875642.1 competence pheromone export protein ComB Regulator
  M594_RS00205 (M594_00205) purC 38663..39370 (+) 708 WP_173875643.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -

Sequence

Protein


Download         Length: 702 a.a.        Molecular weight: 78228.74 Da        Isoelectric Point: 5.3255

>NTDB_id=418222 M594_RS00195 WP_173875641.1 35023..37131(+) (comA) [Streptococcus mitis strain S022-V3-A4]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYSLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLSRERFEEEWTGVTLFMAPSPNYKPHKDQKNGLLSFIPI
LVKQRGLIANIVLATLLVTLINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
LMNGVADVVVADGFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTVIIFAFMKPFEKMNRD
TMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHLLLNVGILWMGAVLVM
DGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLMKGDMDFKQVSYKYGY
GRDVLSDINLTIPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYINYLPQQPYVFNGTIL
ENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDAPVLILDEATSSLDIL
TEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS

Nucleotide


Download         Length: 2109 bp        

>NTDB_id=418222 M594_RS00195 WP_173875641.1 35023..37131(+) (comA) [Streptococcus mitis strain S022-V3-A4]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAGGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGCTATTATTCTTTGGCTCACTTGCGAGAATTGGCCAAGACAACCATGGATGGGACAACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAAATTGGTTTTGAGACGCGAGCAATTAAGGCGGATATGACGCTCTTTGACTTGCCAGATTTG
ACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAAGGGAAACTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGATAG
CATTCATATTGCCGATCCAGATCCCGGGGTGAAGTTGACTAAACTGTCACGTGAGCGTTTTGAGGAAGAATGGACAGGAG
TGACTCTTTTTATGGCACCTAGTCCAAACTATAAGCCTCATAAGGATCAAAAAAATGGCCTTCTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCTAATATCGTTTTGGCAACACTCTTGGTAACCTTGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACGCTGGGGATTATTTCTATTGGGCTGGTCA
TCGTCTATATCCTCCAGCAGATCTTGTCTTACGCTCAGGAGTATCTCTTGCTTGTTTTGGGGCAACGCTTGTCGATTGAT
TTGATGAATGGCGTTGCGGATGTTGTCGTGGCAGATGGTTTCACGGATGCTAATAGTATCATCGATGCGCTAGCTTCGAC
CATCCTTTCGATTTTCCTAGATGTGTCAACGGTTGTCATTATTTCTCTTGTTTTATTTTCACAAAATACCAATCTCTTTT
TCATGACCTTATTGGCACTTCCTATCTACACAGTGATTATCTTTGCTTTTATGAAGCCGTTTGAAAAGATGAATCGGGAC
ACCATGGAAGCCAATGCGGTGCTGTCTTCTTCTATCATTGAGGACATCAACGGTATTGAGACTATCAAGTCTTTGACCAG
TGAAAGTCAGCGTTACCAAAAGATTGACAAGGAATTTGTGGATTATCTGAAGAAATCCTTTACCTATAGTCGGGCAGAGA
GTCAGCAAAAGGCTCTGAAAAAAGTGGCCCATCTCTTGCTCAATGTCGGCATTCTCTGGATGGGGGCTGTTCTGGTCATG
GATGGCAAGATGAGTTTGGGGCAGTTGATTACCTATAATACCTTGCTTGTTTACTTTACCAATCCTTTGGAAAATATCAT
CAATCTGCAAACCAAGCTTCAGACAGCGCAGGTTGCCAATAACCGTTTAAATGAAGTGTATCTAGTAGCTTCGGAGTTTG
AGGAGAAGAAAACGGTTGAGGATTTGAGTTTGATGAAGGGAGATATGGACTTTAAGCAGGTTTCCTACAAGTATGGCTAT
GGTCGAGACGTCTTGTCGGACATCAATTTGACTATTCCGCAGGGTTCTAAGGTGGCTTTTGTGGGGATTTCGGGGTCAGG
TAAGACGACATTGGCCAAGATGATGGTTAATTTTTACGATCCAAGTCAGGGAGAGATTAGTCTGGGTGGTGTCAATCTCA
ATCAGATTGATAAAAAAGCCCTGCGCCAGTATATCAACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTG
GAGAATCTACTTTTGGGAGCCAAGGAGGGGACGACTCAGGAGGATATTTTACGGGCAGTCGAATTGGCAGAGATTCGGGA
GGATATCGAGCGCATGCCACTGAATTACCAGACAGAATTGACTTCGGATGGAGCAGGAATTTCAGGTGGGCAACGGCAGC
GAATTGCTTTGGCACGTGCTCTCTTGACAGATGCACCGGTCTTGATTTTGGATGAGGCGACCAGCAGTTTGGATATTTTG
ACAGAGAAGCGAATTGTCGATAATCTCATGGCTTTAGACAAGACCTTGATTTTCATCGCCCACCGTTTGACTATTGCTGA
GCGGACAGAGAAGGTTGTTGTCTTGGATCAGGGCAAGATTGTTGAAGAAGGAAAGCATGCTGATTTGCTTGCACAGGGTG
GCTTTTACGCCCATTTGGTCAATAGTTAG

Domains

Predicted by InterproScan.

ABC transporter (ABC_tran)

(485-635)

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter transmembrane region (ABC_membrane)

(255-423)

ABC transporter transmembrane region (ABC_membrane)

(170-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus mitis NCTC 12261

95.119

100

0.972
  comA Streptococcus pneumoniae Rx1

94.979

100

0.97
  comA Streptococcus pneumoniae D39

94.979

100

0.97
  comA Streptococcus pneumoniae R6

94.979

100

0.97
  comA Streptococcus mitis SK321

94.7

100

0.967
  comA Streptococcus pneumoniae TIGR4

94.561

100

0.966
  comA Streptococcus gordonii str. Challis substr. CH1

77.824

100

0.795
  comA/nlmT Streptococcus mutans UA159

62.204

100

0.635

Multiple sequence alignment