Detailed information NTG0041822

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: SALIVB_RS04210
• Genome accession: NC_015760
• Coordinates: 957502..958176 (+)
• Length: 224 a.a.
• NCBI ID: WP_013990465.1
• Uniprot ID: -
• Organism: Streptococcus salivarius CCHSS3
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 952502..963176

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SALIVB_RS04185 (SALIVB_0855)	-	952989..953549 (-)	561	WP_013990460.1	ECF transporter S component	-
SALIVB_RS04190 (SALIVB_0856)	-	953616..954188 (-)	573	WP_013990461.1	ECF transporter S component	-
SALIVB_RS04195 (SALIVB_0857)	coaC	954217..954762 (-)	546	WP_013990462.1	phosphopantothenoylcysteine decarboxylase	-
SALIVB_RS04200 (SALIVB_0858)	-	954755..955438 (-)	684	WP_013990463.1	phosphopantothenate--cysteine ligase	-
SALIVB_RS04205 (SALIVB_0859)	-	955633..957303 (+)	1671	WP_013990464.1	formate--tetrahydrofolate ligase	-
SALIVB_RS04210 (SALIVB_0860)	ciaR	957502..958176 (+)	675	WP_013990465.1	response regulator transcription factor	Regulator
SALIVB_RS04215 (SALIVB_0861)	ciaH	958166..959581 (+)	1416	WP_013990466.1	sensor histidine kinase	Regulator
SALIVB_RS04220 (SALIVB_0862)	rpsT	959659..959895 (-)	237	WP_004182129.1	30S ribosomal protein S20	-
SALIVB_RS04225 (SALIVB_0863)	coaA	959965..960885 (-)	921	WP_013990467.1	type I pantothenate kinase	-
SALIVB_RS04230 (SALIVB_0864)	-	960998..961588 (+)	591	WP_013990468.1	class I SAM-dependent methyltransferase	-
SALIVB_RS04235 (SALIVB_0865)	-	961585..962862 (+)	1278	WP_013990469.1	pyrimidine-nucleoside phosphorylase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25371.03 Da
• Isoelectric Point: 4.3354

>NTDB_id=41822 SALIVB_RS04210 WP_013990465.1 957502..958176(+) (ciaR) [Streptococcus salivarius CCHSS3]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELRDKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKHAD

Nucleotide

• Length: 675 bp

>NTDB_id=41822 SALIVB_RS04210 WP_013990465.1 957502..958176(+) (ciaR) [Streptococcus salivarius CCHSS3]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCCAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
TATGCAGGTCTTTGATGGTGATGAAGGCCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTCTTTTAGACTTAATGT
TACCTGAAAAAGATGGTTTCACTGTTCTTAGAGAATTACGTGATAAAGGTGTAACAACTCCTGTACTTATCATGACTGCC
AAGGAAAGTCTAGACGATAAGGGACATGGTTTTGAACTTGGTGCGGATGACTATCTAACCAAACCTTTCTACTTAGAAGA
GTTGAAGATGCGTATTCAAGCACTTTTGAAACGCTCTGGTAAATTTGACCAAAACACACTTTCTTTCGGTGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGGTGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAT
TTCTTACAAAATCAGAATGTGATCTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACCACGGT
ATCAGTTGTCGAGGTTTATGTTTCTAAAATTCGTAAGAAACTTAAAGGAACAGACTTTGCTGCCAACCTCCAAACCTTGA
GAAGTGTGGGGTATATTTTGAAGCATGCTGACTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	87.783	98.661	0.866
ciaR	Streptococcus pneumoniae D39	87.783	98.661	0.866
ciaR	Streptococcus pneumoniae R6	87.783	98.661	0.866
ciaR	Streptococcus pneumoniae TIGR4	87.783	98.661	0.866
ciaR	Streptococcus mutans UA159	86.161	100	0.862
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.222	100	0.384
vicR	Streptococcus mutans UA159	35.983	100	0.384