Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   GPZ88_RS03365 Genome accession   NZ_CP046919
Coordinates   648960..651107 (+) Length   715 a.a.
NCBI ID   WP_074626896.1    Uniprot ID   A0A6G8HZG1
Organism   Streptococcus ruminicola strain CNU_G2     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 643960..656107
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GPZ88_RS03330 (GPZ88_03305) comE/comE1 645233..645964 (-) 732 WP_166043387.1 response regulator transcription factor Regulator
  GPZ88_RS03335 (GPZ88_03310) - 646732..647421 (-) 690 WP_074626894.1 CPBP family intramembrane glutamic endopeptidase -
  GPZ88_RS03340 (GPZ88_03315) - 647486..647638 (-) 153 WP_159428313.1 hypothetical protein -
  GPZ88_RS03345 (GPZ88_03320) - 647652..647792 (-) 141 WP_159428314.1 bacteriocin class II family protein -
  GPZ88_RS03350 (GPZ88_03325) - 647815..648423 (-) 609 WP_074626895.1 CPBP family intramembrane glutamic endopeptidase -
  GPZ88_RS03355 (GPZ88_03330) - 648398..648562 (-) 165 WP_159428316.1 lactococcin G-beta/enterocin 1071B family bacteriocin -
  GPZ88_RS03360 (GPZ88_03335) - 648565..648720 (-) 156 WP_107374736.1 bacteriocin class II family protein -
  GPZ88_RS03365 (GPZ88_03340) comA/nlmT 648960..651107 (+) 2148 WP_074626896.1 peptide cleavage/export ABC transporter Regulator
  GPZ88_RS03370 (GPZ88_03345) - 651117..652499 (+) 1383 WP_166043389.1 bacteriocin secretion accessory protein -
  GPZ88_RS03375 (GPZ88_03350) - 652525..652704 (-) 180 WP_166043391.1 hypothetical protein -
  GPZ88_RS03380 (GPZ88_03355) - 653044..653718 (-) 675 WP_166043393.1 CPBP family intramembrane glutamic endopeptidase -
  GPZ88_RS03385 (GPZ88_03360) - 653751..654440 (-) 690 WP_166043395.1 CPBP family intramembrane glutamic endopeptidase -
  GPZ88_RS03390 (GPZ88_03365) - 654434..654616 (-) 183 WP_166043397.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  GPZ88_RS03395 (GPZ88_03370) rsmA 654986..655858 (-) 873 WP_074564489.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -

Sequence

Protein


Download         Length: 715 a.a.        Molecular weight: 80080.91 Da        Isoelectric Point: 7.9203

>NTDB_id=409409 GPZ88_RS03365 WP_074626896.1 648960..651107(+) (comA/nlmT) [Streptococcus ruminicola strain CNU_G2]
MRRYKYVSQIDMRDCGVAALASVAKHYGSHFSLAHLRELAKTNKEGTTALGIVEAAKKIGFETRAVKADMALFEMDDIPY
PCIVHVNKQGKLQHYYVIYKAKKDYLIIGDPDPSVGVTKLSKEHFAKEWTGVAIFLAPAPTYKPHKDKKNGLTSFLPIIF
KQKALLTYIILASLLVTLINIVGSYYLQGILDDYIPNQLQSTLGIVSIGLVVTYIMQQIMSFSQQYLLVVLSQRLTIDVI
LSYVRHIFELPMSFFATRRTGEVISRFTDANSIIDALASTILSLFLDVSILFIVGSVLILQNAKLFFLTLVALPIYAIII
FAFMKPFERMNHDVMQANSMVSSAIIEDINGIETIKSLTSEETRYRNIDSEFVGYLDKSFTLSKYEAIQTSLKQGAQLIL
NVAILWYGSHLVMTGKISVGQLITYNTLLSYFTNPMENIINLQTKLQSAKVANNRLNEVYLVSSEFDNKEVFNNKDFLKG
DLVFDDVSYKYSFGRDTLSHINLSITEGEKVSLVGVSGSGKTTLAKMMVNFYSPNQGNITLGGYDYKTIDKKILRQHINY
LPQQSYVFSGSILENLTLGASDNITQEDIIKACEIAEIRSDIETMPMAYHTELSDGAGLSGGQKQRLAIARALLTKSPVL
ILDEATSGLDVLTEKRVIHNLLALKDKTIIFVAHRLSIAKQTDRVIVLDKGQIIEQGHHEQLMQNPGFYAQLFQE

Nucleotide


Download         Length: 2148 bp        

>NTDB_id=409409 GPZ88_RS03365 WP_074626896.1 648960..651107(+) (comA/nlmT) [Streptococcus ruminicola strain CNU_G2]
ATGAGGAGATACAAATACGTTAGTCAGATTGATATGCGAGATTGTGGGGTAGCTGCTTTGGCATCAGTTGCTAAACACTA
CGGCTCACATTTTTCGCTTGCTCACTTGAGGGAACTGGCTAAGACGAATAAAGAAGGAACAACTGCTCTTGGAATCGTCG
AGGCAGCTAAAAAGATTGGCTTTGAGACACGCGCTGTAAAAGCTGATATGGCACTTTTTGAGATGGATGATATCCCGTAT
CCTTGCATTGTCCATGTGAATAAGCAAGGAAAACTGCAACACTATTATGTCATCTATAAGGCTAAAAAAGATTATCTAAT
CATCGGTGATCCTGATCCAAGTGTCGGGGTCACTAAACTGTCTAAGGAACATTTTGCAAAAGAATGGACAGGGGTAGCTA
TTTTCTTAGCACCAGCTCCAACTTATAAGCCGCATAAAGATAAGAAAAATGGCTTAACAAGCTTTTTACCAATTATCTTT
AAACAAAAGGCCTTATTGACTTATATCATTCTTGCTAGTTTGCTAGTGACTTTGATTAATATTGTCGGCTCTTATTATCT
TCAAGGAATCTTGGACGACTATATTCCCAATCAACTCCAATCCACCCTTGGAATTGTCTCAATCGGCTTGGTCGTGACTT
ACATCATGCAACAGATTATGAGTTTTTCGCAACAGTATTTACTCGTCGTTCTAAGCCAACGATTAACTATTGATGTGATT
TTGTCTTACGTTCGTCATATTTTTGAATTGCCCATGTCCTTTTTTGCGACAAGACGAACTGGGGAAGTAATTTCACGCTT
TACCGACGCCAACTCTATCATCGATGCCCTTGCTTCAACAATCTTATCGCTTTTTCTCGATGTGAGTATCCTTTTCATCG
TTGGCAGTGTTTTGATTCTGCAGAATGCTAAATTATTCTTTCTCACTCTAGTTGCTCTTCCAATCTATGCCATTATCATC
TTTGCTTTTATGAAGCCGTTTGAGCGTATGAACCATGACGTCATGCAAGCAAATTCCATGGTCAGCTCTGCTATTATTGA
AGATATCAACGGAATTGAAACCATCAAGTCACTCACTAGTGAAGAAACTCGCTATCGCAATATCGATAGTGAATTTGTTG
GTTATTTAGACAAAAGTTTCACTCTTAGTAAATATGAAGCAATCCAAACGTCATTAAAACAGGGAGCACAGCTGATTTTA
AACGTCGCTATTCTTTGGTACGGTTCACATCTAGTTATGACAGGGAAAATTTCTGTTGGGCAGTTGATTACCTACAACAC
TCTCTTATCTTACTTCACAAATCCGATGGAAAATATTATTAATTTACAGACTAAGTTGCAGTCAGCTAAAGTTGCCAATA
ATCGACTTAACGAAGTCTATCTCGTCTCTTCTGAATTTGACAATAAAGAAGTCTTTAACAACAAAGACTTTCTCAAAGGT
GACCTTGTCTTTGATGATGTTTCTTATAAATACAGCTTTGGACGTGATACGCTAAGCCATATTAATCTCTCTATTACAGA
AGGTGAAAAAGTTAGCCTAGTCGGCGTTAGCGGCTCAGGTAAAACCACCCTTGCAAAAATGATGGTTAATTTTTACAGCC
CAAACCAAGGAAACATCACCCTAGGTGGTTATGATTATAAAACCATTGATAAAAAAATCCTTCGACAACATATCAACTAT
TTGCCTCAGCAATCTTATGTCTTCTCAGGAAGCATTTTAGAAAATCTAACCTTGGGAGCTTCTGACAATATCACACAGGA
AGATATTATCAAAGCTTGTGAAATTGCAGAAATTCGATCAGATATCGAAACGATGCCGATGGCTTATCACACTGAACTTT
CAGACGGAGCTGGTTTATCAGGTGGTCAGAAACAGCGCCTTGCTATTGCCAGAGCACTTCTGACTAAGTCACCCGTCTTA
ATCCTAGATGAGGCAACAAGCGGTCTTGATGTGCTGACCGAAAAACGTGTTATCCACAATTTGTTAGCTCTAAAAGACAA
AACCATTATCTTTGTTGCTCACCGCTTAAGCATTGCCAAGCAAACTGACCGTGTCATCGTCCTAGATAAAGGACAAATTA
TCGAACAAGGTCATCACGAGCAACTCATGCAAAATCCTGGCTTTTACGCTCAGCTATTTCAAGAATAA

Domains

Predicted by InterproScan.

Peptidase C39 family (Peptidase_C39)

(3-140)

ABC transporter transmembrane region (ABC_membrane)

(166-436)

ABC transporter (ABC_tran)

(498-647)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A6G8HZG1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

70.787

99.58

0.705
  comA Streptococcus mitis NCTC 12261

66.949

99.021

0.663
  comA Streptococcus mitis SK321

66.384

99.021

0.657
  comA Streptococcus pneumoniae Rx1

66.384

99.021

0.657
  comA Streptococcus pneumoniae D39

66.384

99.021

0.657
  comA Streptococcus pneumoniae R6

66.384

99.021

0.657
  comA Streptococcus pneumoniae TIGR4

66.102

99.021

0.655
  comA Streptococcus gordonii str. Challis substr. CH1

64.466

99.58

0.642

Multiple sequence alignment