Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/comE1   Type   Regulator
Locus tag   GP482_RS07060 Genome accession   NZ_CP046875
Coordinates   1447544..1448275 (-) Length   243 a.a.
NCBI ID   WP_158914540.1    Uniprot ID   A0AAE6R592
Organism   Streptococcus ruminicola strain CNU_77-61     
Function   activate transcription of early competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1442544..1453275
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GP482_RS09650 comD/comD3 1443453..1444244 (-) 792 WP_240187156.1 GHKL domain-containing protein Regulator
  GP482_RS07035 (GP482_07035) - 1444994..1445287 (-) 294 WP_158914536.1 bacteriocin immunity protein -
  GP482_RS07040 (GP482_07040) - 1445315..1445620 (-) 306 WP_158914537.1 bacteriocin immunity protein -
  GP482_RS07045 (GP482_07045) - 1445633..1445782 (-) 150 WP_039696228.1 hypothetical protein -
  GP482_RS07050 (GP482_07050) comC/comC1 1446045..1446197 (+) 153 WP_158914538.1 hypothetical protein Regulator
  GP482_RS07055 (GP482_07055) comD/comD1 1446220..1447539 (-) 1320 WP_158914539.1 GHKL domain-containing protein Regulator
  GP482_RS07060 (GP482_07060) comE/comE1 1447544..1448275 (-) 732 WP_158914540.1 response regulator transcription factor Regulator
  GP482_RS07065 (GP482_07065) - 1448780..1449391 (-) 612 WP_254058925.1 thioredoxin family protein -
  GP482_RS07070 (GP482_07070) - 1449581..1449892 (-) 312 WP_061408660.1 hypothetical protein -
  GP482_RS07075 (GP482_07075) - 1449958..1450191 (-) 234 WP_158914541.1 ComC/BlpC family peptide pheromone/bacteriocin -
  GP482_RS07080 (GP482_07080) comA/nlmT 1450427..1452574 (+) 2148 WP_158914542.1 peptide cleavage/export ABC transporter Regulator
  GP482_RS09655 - 1452584..1452712 (+) 129 Protein_1381 competence protein ComB -

Sequence

Protein


Download         Length: 243 a.a.        Molecular weight: 28284.31 Da        Isoelectric Point: 6.3907

>NTDB_id=409134 GP482_RS07060 WP_158914540.1 1447544..1448275(-) (comE/comE1) [Streptococcus ruminicola strain CNU_77-61]
MLDIFILEDNITQQFRIERQIEAIMRKNNWAYQHLEAFAVSEDIIARVSKEDSHQIFFLDLEIKGDEKQGIDVARAIREK
DSTAIIVFVTTHFEFMLLTYHSLVGAIDFIDKNLNDAAFEQRLELCLKEALKYQKGNLGENSYLFETAKARIRVAYDDIL
YFETSPTVHRVILHTKTGQTEFYGTIAEVAKSDKRLLKCHRSFVINVNNVTEFDKSTRTAYFENGSYCQVSRDKVKKLMA
EMR

Nucleotide


Download         Length: 732 bp        

>NTDB_id=409134 GP482_RS07060 WP_158914540.1 1447544..1448275(-) (comE/comE1) [Streptococcus ruminicola strain CNU_77-61]
ATGTTAGATATTTTTATCCTTGAGGATAATATCACGCAACAATTTCGTATTGAGCGACAGATAGAGGCAATTATGAGAAA
AAATAATTGGGCTTATCAGCACTTGGAAGCTTTTGCGGTATCTGAGGATATTATTGCAAGAGTATCTAAAGAAGATAGTC
ATCAGATTTTCTTTCTTGATTTAGAAATTAAAGGGGATGAAAAGCAAGGAATTGACGTGGCAAGAGCCATCCGTGAGAAG
GATTCGACAGCTATTATTGTTTTTGTAACGACACATTTTGAATTTATGCTTTTAACTTATCATTCGTTGGTTGGTGCGAT
TGATTTCATTGATAAAAATTTAAATGATGCAGCTTTTGAACAACGTCTAGAGTTATGCTTGAAGGAAGCTCTTAAGTATC
AAAAAGGAAATTTAGGTGAGAATTCTTACCTTTTTGAAACTGCCAAAGCGAGAATTCGTGTAGCTTACGATGATATTTTA
TATTTTGAAACATCGCCAACCGTCCACCGAGTGATTTTACACACAAAAACAGGTCAAACAGAGTTTTATGGCACAATTGC
TGAGGTAGCCAAATCAGATAAACGTTTGTTGAAATGTCACCGCTCATTCGTGATTAATGTTAATAATGTCACTGAATTTG
ATAAAAGCACCCGAACAGCTTATTTCGAAAACGGCTCTTACTGCCAAGTCTCAAGAGATAAAGTCAAAAAACTGATGGCA
GAAATGAGGTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-123)

LytTr DNA-binding domain (LytTR)

(152-240)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/comE1 Streptococcus equinus JB1

87.654

100

0.877
  comE/comE2 Streptococcus equinus JB1

46.694

99.588

0.465
  comE/blpR Streptococcus mutans UA159

45.643

99.177

0.453

Multiple sequence alignment