Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   GOM47_RS06015 Genome accession   NZ_CP046524
Coordinates   1182449..1183123 (-) Length   224 a.a.
NCBI ID   WP_000590630.1    Uniprot ID   A0A4V0BT06
Organism   Streptococcus oralis strain SOT     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1177449..1188123
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GOM47_RS05990 (GOM47_05995) - 1177581..1178510 (-) 930 WP_235080174.1 peptidase U32 family protein -
  GOM47_RS05995 (GOM47_06000) - 1178637..1179317 (-) 681 WP_235080175.1 ABC transporter ATP-binding protein -
  GOM47_RS06000 (GOM47_06005) - 1179331..1180386 (-) 1056 WP_235080176.1 ABC transporter permease -
  GOM47_RS06005 (GOM47_06010) - 1180773..1181057 (+) 285 WP_235080177.1 DUF3270 domain-containing protein -
  GOM47_RS06010 (GOM47_06015) ciaH 1181122..1182459 (-) 1338 WP_235080178.1 sensor histidine kinase Regulator
  GOM47_RS06015 (GOM47_06020) ciaR 1182449..1183123 (-) 675 WP_000590630.1 two-component system response regulator CiaR Regulator
  GOM47_RS06020 (GOM47_06025) - 1183234..1185780 (-) 2547 WP_235080179.1 M1 family metallopeptidase -
  GOM47_RS06025 (GOM47_06030) - 1185903..1186343 (-) 441 WP_235080180.1 ASCH domain-containing protein -
  GOM47_RS06030 (GOM47_06035) - 1186340..1187188 (-) 849 WP_235080181.1 putative PEP-binding protein -
  GOM47_RS06035 (GOM47_06040) - 1187230..1187835 (-) 606 WP_235080182.1 DUF6707 family protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25479.29 Da        Isoelectric Point: 4.2660

>NTDB_id=404996 GOM47_RS06015 WP_000590630.1 1182449..1183123(-) (ciaR) [Streptococcus oralis strain SOT]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGDIVVNLSTNEVKVEDTPVELLGKEFELLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFAENLQTLRSVGYILKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=404996 GOM47_RS06015 WP_000590630.1 1182449..1183123(-) (ciaR) [Streptococcus oralis strain SOT]
ATGATAAAAATCTTATTAGTAGAAGATGACCTGGGTCTGTCAAACTCAGTATTTGACTTTTTAGATGATTTTGCAGATGT
CATGCAGGTCTTTGATGGAGAAGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGACTTGATTTTGCTTGACCTGATGT
TGCCTGAAAAAAATGGATTCCAAGTTTTGAAAGAGTTGCGCGAAAAAGGAATTACGACACCAGTCCTTATCATGACTGCT
AAGGAAAGTTTGGATGACAAGGGACATGGTTTTGAGTTGGGAGCGGATGACTACCTCACCAAACCTTTTTATCTAGAAGA
ACTCAAAATGCGGATCCAAGCCCTTCTCAAACGTTCAGGTAAGTTTAACGAAAACACCTTGACCTATGGGGATATTGTCG
TCAACCTTTCAACGAATGAAGTGAAGGTGGAAGATACTCCTGTGGAACTACTCGGAAAAGAGTTTGAGTTATTGGTTTAC
TTCCTTCAAAATCAAAATGTTATTCTTCCCAAGACACAGATTTTTGACCGTCTATGGGGATTTGATAGTGATACGACTAT
TTCCGTTGTAGAAGTCTATGTTTCAAAAGTTCGTAAGAAACTGAAGGGAACAGCCTTTGCTGAAAATCTTCAAACCTTGC
GTAGTGTCGGGTATATTTTAAAAGATGTTCAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4V0BT06

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae TIGR4

97.768

100

0.978
  ciaR Streptococcus pneumoniae D39

97.768

100

0.978
  ciaR Streptococcus pneumoniae R6

97.768

100

0.978
  ciaR Streptococcus pneumoniae Rx1

97.768

100

0.978
  ciaR Streptococcus mutans UA159

87.5

100

0.875
  vicR Streptococcus mutans UA159

36.481

100

0.379
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.283

100

0.366

Multiple sequence alignment