Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   GOM47_RS06010 Genome accession   NZ_CP046524
Coordinates   1181122..1182459 (-) Length   445 a.a.
NCBI ID   WP_235080178.1    Uniprot ID   -
Organism   Streptococcus oralis strain SOT     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1176122..1187459
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GOM47_RS05985 (GOM47_05990) rpiA 1176792..1177475 (-) 684 WP_235080173.1 ribose-5-phosphate isomerase RpiA -
  GOM47_RS05990 (GOM47_05995) - 1177581..1178510 (-) 930 WP_235080174.1 peptidase U32 family protein -
  GOM47_RS05995 (GOM47_06000) - 1178637..1179317 (-) 681 WP_235080175.1 ABC transporter ATP-binding protein -
  GOM47_RS06000 (GOM47_06005) - 1179331..1180386 (-) 1056 WP_235080176.1 ABC transporter permease -
  GOM47_RS06005 (GOM47_06010) - 1180773..1181057 (+) 285 WP_235080177.1 DUF3270 domain-containing protein -
  GOM47_RS06010 (GOM47_06015) ciaH 1181122..1182459 (-) 1338 WP_235080178.1 sensor histidine kinase Regulator
  GOM47_RS06015 (GOM47_06020) ciaR 1182449..1183123 (-) 675 WP_000590630.1 two-component system response regulator CiaR Regulator
  GOM47_RS06020 (GOM47_06025) - 1183234..1185780 (-) 2547 WP_235080179.1 M1 family metallopeptidase -
  GOM47_RS06025 (GOM47_06030) - 1185903..1186343 (-) 441 WP_235080180.1 ASCH domain-containing protein -
  GOM47_RS06030 (GOM47_06035) - 1186340..1187188 (-) 849 WP_235080181.1 putative PEP-binding protein -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 50735.40 Da        Isoelectric Point: 9.5838

>NTDB_id=404995 GOM47_RS06010 WP_235080178.1 1181122..1182459(-) (ciaH) [Streptococcus oralis strain SOT]
MFNKLKKTWYADDFSYFIRNFGVFTLIFSAMTLIILQVMHSSLYTSVDEKLQALSSSPQAVIQLALNRATEEVKDIQPAT
ADASKAEIKPNVSSNTEVLLFDKDFNQLLLGNRFLGLDKIKLDKKELNHIRQIQVVNSYGQEETYRMVLMETNSSTVSSN
VKYAAVLINTSQLEQISQNHEHLIVVVMASFWLLSLIASVYLARVSVKPLLESMQKQKSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMESSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPEIAEVSPQFFKTTFANYELIASENDRVFDYENRV
YRPFMTDQLLLKQLMTILFDNAIKYTEEDGKIEFVVHATDRHLYLTVTDNGIGISAADKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALRGTISVKDNKPRGTIFEVKIAIQSPSKRKNK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=404995 GOM47_RS06010 WP_235080178.1 1181122..1182459(-) (ciaH) [Streptococcus oralis strain SOT]
ATGTTCAATAAACTAAAAAAAACATGGTATGCGGATGATTTCAGCTATTTCATTCGAAACTTTGGAGTGTTCACCCTAAT
CTTCTCTGCTATGACCTTGATTATCCTCCAGGTCATGCACTCGAGTCTCTACACTTCTGTAGATGAAAAACTACAAGCTC
TTAGTAGTAGTCCCCAAGCGGTTATCCAGTTAGCCCTTAATCGGGCAACTGAGGAAGTCAAGGATATTCAACCAGCAACA
GCGGATGCCAGCAAGGCTGAAATCAAGCCCAATGTTAGCTCCAATACAGAAGTTTTGCTTTTTGACAAGGATTTTAACCA
ACTCTTACTGGGCAATCGCTTTTTAGGCTTGGACAAAATCAAGCTGGACAAGAAAGAGTTGAATCATATTCGGCAAATTC
AAGTTGTCAACAGCTATGGTCAGGAAGAAACCTATCGAATGGTCTTGATGGAAACCAACTCTTCCACCGTATCAAGTAAT
GTCAAATATGCGGCGGTTCTAATCAATACCAGCCAGCTTGAGCAAATCAGCCAAAATCACGAGCATTTAATTGTTGTAGT
GATGGCTAGTTTCTGGCTCCTGTCTTTAATTGCCAGTGTTTACCTGGCACGTGTCAGTGTCAAACCCCTATTGGAAAGCA
TGCAAAAGCAGAAGTCCTTTGTTGAAAATGCGAGTCACGAACTGAGAACGCCCTTGGCTGTTTTACAAAATCGTTTAGAG
ACTCTCTTTCGAAAACCAGAAGCGACGATTATGGAATCCAGCGAAAGTATTGCTTCTAGCCTTGAAGAAGTTCGCAACAT
GCGTTTCCTCACGACCAACCTTCTCAATCTAGCACGTCGAGACGATGGGATCAAACCAGAAATAGCAGAAGTTTCTCCAC
AATTCTTTAAAACAACCTTTGCCAACTATGAGTTGATTGCTTCTGAAAATGATCGTGTTTTTGACTATGAAAATCGAGTT
TATCGCCCATTCATGACCGATCAGTTGCTCCTAAAACAGCTCATGACCATCTTGTTTGATAATGCCATCAAGTATACCGA
AGAGGATGGCAAGATTGAGTTTGTAGTTCATGCCACAGATCGCCATCTCTATCTTACAGTAACAGATAATGGAATTGGGA
TCTCAGCTGCCGATAAGAAGAAAATCTTTGACCGCTTTTATCGTGTAGACAAGGCGAGAACCCGTCAGAAAGGTGGTTTT
GGTCTAGGACTATCTTTGGCCAAGCAGATCGTAGATGCCTTACGAGGAACGATTAGCGTAAAAGATAACAAACCTAGAGG
AACAATTTTTGAAGTTAAGATCGCTATTCAATCTCCTTCAAAACGTAAGAATAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)

His Kinase A (phospho-acceptor) domain (HisKA)

(218-283)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

83.973

99.551

0.836
  ciaH Streptococcus pneumoniae D39

83.973

99.551

0.836
  ciaH Streptococcus pneumoniae R6

83.973

99.551

0.836
  ciaH Streptococcus pneumoniae TIGR4

83.973

99.551

0.836
  ciaH Streptococcus mutans UA159

55.479

98.427

0.546

Multiple sequence alignment