Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   GOM48_RS06125 Genome accession   NZ_CP046523
Coordinates   1208516..1209190 (-) Length   224 a.a.
NCBI ID   WP_061416663.1    Uniprot ID   A0A139MDC3
Organism   Streptococcus oralis strain SOD     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1203516..1214190
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GOM48_RS06100 (GOM48_06095) - 1203656..1204585 (-) 930 WP_235096445.1 peptidase U32 family protein -
  GOM48_RS06105 (GOM48_06100) - 1204710..1205390 (-) 681 WP_235096446.1 ABC transporter ATP-binding protein -
  GOM48_RS06110 (GOM48_06105) - 1205404..1206459 (-) 1056 WP_235096447.1 ABC transporter permease -
  GOM48_RS06115 (GOM48_06110) - 1206840..1207124 (+) 285 WP_235096448.1 DUF3270 domain-containing protein -
  GOM48_RS06120 (GOM48_06115) ciaH 1207189..1208526 (-) 1338 WP_235096449.1 sensor histidine kinase Regulator
  GOM48_RS06125 (GOM48_06120) ciaR 1208516..1209190 (-) 675 WP_061416663.1 two-component system response regulator CiaR Regulator
  GOM48_RS06130 (GOM48_06125) - 1209300..1211846 (-) 2547 WP_235096450.1 M1 family metallopeptidase -
  GOM48_RS06135 (GOM48_06130) - 1211967..1212407 (-) 441 WP_235096451.1 ASCH domain-containing protein -
  GOM48_RS06140 (GOM48_06135) - 1212404..1213252 (-) 849 WP_235096452.1 putative PEP-binding protein -
  GOM48_RS06145 (GOM48_06140) - 1213294..1214022 (-) 729 WP_235096453.1 GNAT family N-acetyltransferase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25465.26 Da        Isoelectric Point: 4.2660

>NTDB_id=404924 GOM48_RS06125 WP_061416663.1 1208516..1209190(-) (ciaR) [Streptococcus oralis strain SOD]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGISTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGDIVVNLSTNEVKVEDTPVELLGKEFELLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFAENLQTLRSVGYILKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=404924 GOM48_RS06125 WP_061416663.1 1208516..1209190(-) (ciaR) [Streptococcus oralis strain SOD]
ATGATAAAAATCTTATTAGTAGAAGATGACCTGGGCCTGTCAAACTCAGTATTTGACTTTTTAGATGATTTTGCAGATGT
CATGCAGGTTTTTGATGGAGAAGAAGGTCTCTACGAAGCTGAAAGTGGCGTTTATGACTTGATTTTGCTTGACCTGATGT
TGCCTGAAAAAAATGGTTTTCAAGTCTTGAAAGAGTTGCGAGAAAAAGGGATCTCAACACCAGTCCTTATCATGACTGCT
AAGGAAAGTTTGGATGACAAGGGACATGGTTTTGAGTTGGGAGCGGATGACTACCTCACCAAGCCTTTCTACCTAGAAGA
ACTCAAAATGCGGATTCAAGCCCTTCTCAAACGTTCAGGCAAGTTTAACGAAAACACCTTGACCTATGGGGATATTGTCG
TCAACCTTTCAACGAATGAAGTGAAAGTGGAAGATACTCCTGTGGAACTGCTCGGAAAAGAGTTTGAGTTATTGGTTTAC
TTCCTTCAAAATCAAAATGTTATTCTTCCCAAGACACAAATTTTTGACCGTCTATGGGGATTTGATAGCGATACGACTAT
TTCCGTTGTAGAAGTATATGTCTCAAAAGTTCGTAAGAAATTGAAGGGGACAGCCTTTGCTGAAAACCTTCAAACCTTGC
GTAGTGTCGGGTATATTTTAAAAGATGTTCAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A139MDC3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae TIGR4

97.321

100

0.973
  ciaR Streptococcus pneumoniae D39

97.321

100

0.973
  ciaR Streptococcus pneumoniae R6

97.321

100

0.973
  ciaR Streptococcus pneumoniae Rx1

97.321

100

0.973
  ciaR Streptococcus mutans UA159

87.054

100

0.871
  vicR Streptococcus mutans UA159

36.481

100

0.379
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.283

100

0.366

Multiple sequence alignment