Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   GOM48_RS06120 Genome accession   NZ_CP046523
Coordinates   1207189..1208526 (-) Length   445 a.a.
NCBI ID   WP_235096449.1    Uniprot ID   -
Organism   Streptococcus oralis strain SOD     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1202189..1213526
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GOM48_RS06095 (GOM48_06090) rpiA 1202867..1203550 (-) 684 WP_235096444.1 ribose-5-phosphate isomerase RpiA -
  GOM48_RS06100 (GOM48_06095) - 1203656..1204585 (-) 930 WP_235096445.1 peptidase U32 family protein -
  GOM48_RS06105 (GOM48_06100) - 1204710..1205390 (-) 681 WP_235096446.1 ABC transporter ATP-binding protein -
  GOM48_RS06110 (GOM48_06105) - 1205404..1206459 (-) 1056 WP_235096447.1 ABC transporter permease -
  GOM48_RS06115 (GOM48_06110) - 1206840..1207124 (+) 285 WP_235096448.1 DUF3270 domain-containing protein -
  GOM48_RS06120 (GOM48_06115) ciaH 1207189..1208526 (-) 1338 WP_235096449.1 sensor histidine kinase Regulator
  GOM48_RS06125 (GOM48_06120) ciaR 1208516..1209190 (-) 675 WP_061416663.1 two-component system response regulator CiaR Regulator
  GOM48_RS06130 (GOM48_06125) - 1209300..1211846 (-) 2547 WP_235096450.1 M1 family metallopeptidase -
  GOM48_RS06135 (GOM48_06130) - 1211967..1212407 (-) 441 WP_235096451.1 ASCH domain-containing protein -
  GOM48_RS06140 (GOM48_06135) - 1212404..1213252 (-) 849 WP_235096452.1 putative PEP-binding protein -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 50824.54 Da        Isoelectric Point: 9.5602

>NTDB_id=404923 GOM48_RS06120 WP_235096449.1 1207189..1208526(-) (ciaH) [Streptococcus oralis strain SOD]
MFNKLKKTWYADDFSYFIRNFGVFTLIFSAMTLIILQVMHSSLYTSVDEKLQALSSSPQAVIQLALNRATEEVKDIQPAT
ADASKAEIKPNVSSNTEVLLFDKDFNQLLLGNRFLGLDKIKLDKKELNHIRQIQVVNSYGQEETYRMILMETNSSSVSSN
VKYAAVLINTSQLEQISQNHEHLIVVVMASFWLLSLIASVYLARVSVKPLLESMQKQKSFVENASHELRTPLAVLQNRLE
NLFRKPEATIMESSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPEIAEVSPQFFKTTFANYELIASENDRVFDYENRI
YRPFMTDQLLLKQLMTILFDNAIKYTEEDGKIEFVVYATDRHLYLTVTDNGIGISAPDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALRGTISVKDNKPRGTIFEVKIAIQSPPKRKNK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=404923 GOM48_RS06120 WP_235096449.1 1207189..1208526(-) (ciaH) [Streptococcus oralis strain SOD]
ATGTTCAATAAACTAAAAAAAACATGGTATGCGGATGATTTCAGTTATTTTATTCGAAACTTTGGAGTGTTCACCCTGAT
CTTCTCTGCTATGACCTTGATTATCCTTCAGGTCATGCACTCGAGTCTCTACACTTCTGTAGATGAAAAACTCCAAGCCC
TTAGTAGTAGTCCCCAAGCGGTTATCCAGTTAGCCCTGAATAGGGCAACTGAAGAGGTCAAGGACATCCAACCCGCAACC
GCGGATGCCAGCAAGGCTGAAATCAAACCCAATGTCAGTTCCAATACGGAAGTCTTGCTCTTTGACAAGGATTTTAACCA
ACTCTTACTGGGCAATCGTTTTTTAGGCTTGGATAAGATCAAACTGGACAAGAAAGAGTTGAATCACATTCGGCAAATCC
AAGTTGTCAATAGCTACGGTCAGGAAGAAACCTACCGGATGATCTTGATGGAAACCAATTCTTCCTCCGTATCAAGCAAT
GTCAAATATGCGGCAGTCTTGATCAATACCAGCCAGCTTGAGCAAATCAGCCAAAACCACGAGCATTTAATTGTTGTAGT
GATGGCTAGTTTCTGGCTTCTGTCTTTAATTGCCAGTGTTTACCTAGCACGTGTCAGTGTCAAACCCTTGCTGGAAAGCA
TGCAAAAGCAGAAGTCCTTTGTTGAAAATGCGAGTCACGAACTGAGAACACCTTTGGCCGTTTTACAAAATCGTTTAGAG
AATCTCTTTCGAAAACCAGAGGCAACGATTATGGAATCCAGCGAAAGCATCGCTTCGAGTCTTGAAGAAGTTCGCAACAT
GCGCTTCCTTACAACTAATCTTCTCAACCTTGCACGTCGAGATGATGGAATCAAGCCAGAAATAGCAGAAGTATCACCAC
AGTTCTTTAAGACGACCTTTGCTAACTATGAGTTGATTGCTTCTGAAAATGATCGAGTTTTTGACTATGAAAATCGGATT
TATCGTCCCTTCATGACCGATCAGTTGCTCCTAAAACAGCTCATGACCATCTTATTTGATAATGCTATCAAGTATACCGA
AGAAGATGGGAAAATTGAGTTTGTGGTTTATGCTACAGATCGCCACCTCTATCTAACAGTAACAGATAATGGTATTGGAA
TCTCAGCTCCTGACAAGAAGAAAATTTTTGACCGCTTTTACCGTGTAGACAAGGCGAGAACCCGTCAGAAGGGTGGCTTT
GGTCTAGGACTATCTTTGGCTAAGCAGATCGTAGATGCCTTACGAGGAACGATTAGCGTCAAAGATAACAAACCTAGAGG
AACAATTTTTGAAGTTAAGATCGCTATTCAATCTCCTCCAAAACGTAAGAATAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)

His Kinase A (phospho-acceptor) domain (HisKA)

(218-283)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

84.199

99.551

0.838
  ciaH Streptococcus pneumoniae D39

84.199

99.551

0.838
  ciaH Streptococcus pneumoniae R6

84.199

99.551

0.838
  ciaH Streptococcus pneumoniae TIGR4

84.199

99.551

0.838
  ciaH Streptococcus mutans UA159

55.023

98.427

0.542

Multiple sequence alignment