Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   GOM48_RS00225 Genome accession   NZ_CP046523
Coordinates   36242..38395 (+) Length   717 a.a.
NCBI ID   WP_235097636.1    Uniprot ID   -
Organism   Streptococcus oralis strain SOD     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 31242..43395
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GOM48_RS00170 (GOM48_00165) recO 31618..32388 (+) 771 WP_235097619.1 DNA repair protein RecO -
  GOM48_RS00175 (GOM48_00170) plsX 32385..33377 (+) 993 WP_235097621.1 phosphate acyltransferase PlsX -
  GOM48_RS00180 (GOM48_00175) - 33382..33618 (+) 237 WP_235097623.1 acyl carrier protein -
  GOM48_RS00185 (GOM48_00180) - 33947..34090 (+) 144 WP_235097625.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  GOM48_RS00190 (GOM48_00185) - 34106..34264 (+) 159 WP_235097627.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  GOM48_RS00195 - 34278..34454 (+) 177 WP_235097628.1 hypothetical protein -
  GOM48_RS00200 - 34648..34803 (+) 156 WP_000732133.1 hypothetical protein -
  GOM48_RS00205 (GOM48_00190) - 34842..35054 (+) 213 WP_235097630.1 bacteriocin immunity protein -
  GOM48_RS00210 (GOM48_00195) - 35135..35323 (+) 189 WP_131200675.1 hypothetical protein -
  GOM48_RS00215 (GOM48_00200) - 35348..35557 (+) 210 WP_235097632.1 bacteriocin immunity protein -
  GOM48_RS00220 - 35882..36076 (+) 195 WP_235097634.1 hypothetical protein -
  GOM48_RS00225 (GOM48_00205) comA 36242..38395 (+) 2154 WP_235097636.1 peptide cleavage/export ABC transporter ComA Regulator
  GOM48_RS00230 (GOM48_00210) comB 38408..39757 (+) 1350 WP_235097638.1 competence pheromone export protein ComB Regulator
  GOM48_RS00235 (GOM48_00215) purC 39925..40632 (+) 708 WP_000038498.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80454.78 Da        Isoelectric Point: 7.1567

>NTDB_id=404885 GOM48_RS00225 WP_235097636.1 36242..38395(+) (comA) [Streptococcus oralis strain SOD]
MKFKKRHYRPQVDQMDCGVASLAMVFGYYGSYYSLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKKHIHIADPDPGVKLTKISRERFAQEWTGISLFMAPSPDYKPHKEKKQGLLSFLPI
LLKQRGLITNIVLATLLVTLINIVGSYYLQSIIDSYVPDQMRTTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTILIISLVLFSQNMTLFFISLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESSRYQKIDKEFVAYLKKSFTYSRAESQQKALKKVAQL
LLNVAVLWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSMM
KGDVTFKQVHYKYGYGRDVLSDINLMIPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELTEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLNQGKIVEEGTHADLLAQDGFYAHLVNS

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=404885 GOM48_RS00225 WP_235097636.1 36242..38395(+) (comA) [Streptococcus oralis strain SOD]
ATGAAATTTAAGAAAAGGCACTACCGTCCTCAGGTGGATCAGATGGATTGTGGCGTGGCTTCCTTGGCTATGGTCTTTGG
TTACTACGGTAGTTATTACTCTTTGGCTCATCTACGAGAACTAGCTAAGACGACCATGGATGGGACAACTGCTTTGGGTC
TTGTAAAGGTGGCAGAGGAAATTGGCTTTGAGACGCGAGCTATCAAGGCGGATATGACGCTCTTTGACTTGCCAGATTTG
ACCTTTCCCTTTGTGGCTCATGTGCTTAAGGAAGGGAAATTGCTCCACTACTATGTGGTGACAGGTCAGGATAAAAAGCA
CATCCATATCGCTGATCCAGATCCTGGTGTCAAGCTGACCAAGATTTCCCGTGAGCGATTTGCGCAAGAGTGGACAGGGA
TCAGTCTCTTTATGGCGCCATCTCCGGACTATAAGCCCCATAAGGAGAAAAAACAGGGGCTCCTATCCTTCTTGCCAATC
TTACTCAAACAGCGTGGCTTAATTACCAATATCGTCCTAGCGACACTCTTGGTAACCCTGATCAACATTGTAGGTTCTTA
TTATCTTCAGTCCATCATTGATAGTTACGTACCAGACCAGATGCGTACGACGCTAGGAATTATTTCTATTGGTTTGGTCA
TCGTCTATATTCTCCAGCAGATTTTGTCTTATGCTCAGGAGTATCTCTTGCTGGTCCTTGGGCAACGCTTGTCAATTGAC
GTGATTTTGTCCTACATCAAGCATGTTTTTCACCTGCCGATGTCCTTTTTTGCGACACGCAGGACAGGAGAGATTGTATC
TCGTTTTACGGATGCTAATAGTATCATTGATGCGCTAGCTTCGACCATCTTGTCTATCTTTTTAGATGTGTCGACGATTT
TGATTATTTCGCTTGTCTTGTTTTCACAAAATATGACGCTCTTTTTCATTAGTCTGCTTGCACTTCCCATCTATACAGTG
ATTATCTTTGCCTTTATGAAGCCTTTTGAAAAGATGAATCGGGACACTATGGAAGCCAATGCAGTTCTGTCTTCTTCTAT
CATCGAGGACATCAACGGTATTGAGACTATTAAATCTTTGACTAGTGAAAGTTCACGCTATCAAAAGATTGATAAGGAAT
TTGTAGCTTATCTGAAAAAATCTTTTACCTATAGTCGGGCAGAAAGTCAGCAAAAGGCATTGAAAAAAGTTGCTCAGCTC
CTGCTCAATGTTGCCGTTCTCTGGATGGGAGCAGTTCTTGTCATGGATGGGAAAATGAGTTTGGGTCAGCTGATTACCTA
TAATACTTTGCTTGTTTACTTTACCAACCCTTTGGAAAATATCATCAACCTGCAAACCAAACTTCAGACAGCGCAGGTTG
CTAATAATCGTCTTAACGAAGTCTATCTAGTAGCTTCGGAGTTTGAGGAGAAGAAAACAGTCGAAGATTTGAGCATGATG
AAGGGAGATGTGACCTTTAAACAAGTCCACTATAAGTATGGCTATGGTCGTGACGTCTTGTCGGATATCAATTTGATGAT
TCCCCAAGGTTCTAAAGTAGCTTTTGTGGGGATTTCAGGGTCAGGTAAGACGACCTTGGCCAAGATGATGGTTAACTTTT
ACGACCCTAGTCAGGGAGAGATTAGTCTGGGCGGTGTCAATCTTAATCAGATTGATAAAAAAGCCTTGCGCCAGTATATA
AACTATCTACCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGAGAATCTTCTCCTTGGAGCCAAGGAAGGGACGAC
ACAGGAAGATATCTTACGAGCAGTTGAATTGACTGAAATTCGGGAGGATATCGAGCGCATGCCACTGAATTATCAGACAG
AATTGACTTCGGATGGAGCAGGTATTTCTGGGGGGCAACGGCAGCGAATTGCTCTGGCGCGTGCTCTTTTAACGGATGCG
CCTGTTCTGATATTGGATGAGGCGACCAGCAGTCTGGATATCTTGACAGAGAAGCGGATTGTCGATAATCTCATGGCTTT
GGATAAGACCTTGATTTTCATTGCCCACCGCTTGACTATTGCTGAGCGGACAGAAAAGGTTGTTGTTCTGAATCAGGGCA
AGATTGTCGAAGAGGGCACCCATGCAGACTTGCTTGCTCAAGATGGTTTTTATGCCCATTTGGTGAATAGCTAG

Domains

Predicted by InterproScan.

ABC transporter (ABC_tran)

(500-650)

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter transmembrane region (ABC_membrane)

(170-438)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus mitis NCTC 12261

94.979

100

0.95
  comA Streptococcus pneumoniae Rx1

94.7

100

0.947
  comA Streptococcus pneumoniae D39

94.7

100

0.947
  comA Streptococcus pneumoniae R6

94.7

100

0.947
  comA Streptococcus mitis SK321

94.7

100

0.947
  comA Streptococcus pneumoniae TIGR4

94.282

100

0.943
  comA Streptococcus gordonii str. Challis substr. CH1

80.614

100

0.806
  comA/nlmT Streptococcus mutans UA159

64.435

100

0.644

Multiple sequence alignment