Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   GL187_RS10925 Genome accession   NZ_CP046379
Coordinates   2135641..2136822 (+) Length   393 a.a.
NCBI ID   WP_000681598.1    Uniprot ID   A0A0B7M448
Organism   Streptococcus pneumoniae strain 563     
Function   degrading CSP; selective degradation of ComEA and ComEC (predicted from homology)   
Competence regulation

Genomic Context

Location: 2130641..2141822
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GL187_RS10885 (GL187_11020) - 2131692..2132234 (+) 543 WP_001158269.1 TetR/AcrR family transcriptional regulator -
  GL187_RS10900 (GL187_11035) comE 2132477..2133229 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  GL187_RS10905 (GL187_11040) comD/comD2 2133226..2134551 (-) 1326 WP_024477997.1 competence system sensor histidine kinase ComD Regulator
  GL187_RS10910 (GL187_11045) comC/comC2 2134572..2134697 (-) 126 WP_197097936.1 competence-stimulating peptide ComC Regulator
  GL187_RS10920 (GL187_11055) rlmH 2134979..2135458 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  GL187_RS10925 (GL187_11060) htrA 2135641..2136822 (+) 1182 WP_000681598.1 S1C family serine protease Regulator
  GL187_RS10930 (GL187_11065) spo0J 2136880..2137638 (+) 759 WP_000410383.1 ParB/RepB/Spo0J family partition protein Regulator
  GL187_RS10935 (GL187_11070) dnaA 2137851..2139212 (+) 1362 WP_000660615.1 chromosomal replication initiator protein DnaA -

Sequence

Protein


Download         Length: 393 a.a.        Molecular weight: 41827.69 Da        Isoelectric Point: 6.8902

>NTDB_id=403729 GL187_RS10925 WP_000681598.1 2135641..2136822(+) (htrA) [Streptococcus pneumoniae strain 563]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide


Download         Length: 1182 bp        

>NTDB_id=403729 GL187_RS10925 WP_000681598.1 2135641..2136822(+) (htrA) [Streptococcus pneumoniae strain 563]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAATAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTAAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAAATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(103-248)

PDZ domain (PDZ_2)

(289-384)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7M448

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus pneumoniae Rx1

99.746

100

0.997
  htrA Streptococcus pneumoniae D39

99.746

100

0.997
  htrA Streptococcus pneumoniae R6

99.746

100

0.997
  htrA Streptococcus pneumoniae TIGR4

99.746

100

0.997
  htrA Streptococcus mitis NCTC 12261

97.455

100

0.975
  htrA Streptococcus gordonii str. Challis substr. CH1

66.667

100

0.672
  htrA Streptococcus mutans UA159

54.822

100

0.55

Multiple sequence alignment