Detailed information
Bioinformatically predicted
Overview
| Name | comB | Type | Regulator |
| Locus tag | GL187_RS00325 | Genome accession | NZ_CP046379 |
| Coordinates | 51892..53241 (+) | Length | 449 a.a. |
| NCBI ID | WP_024477962.1 | Uniprot ID | - |
| Organism | Streptococcus pneumoniae strain 563 | ||
| Function | transport of ComC (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 10009..63201 | 51892..53241 | within | 0 |
Gene organization within MGE regions
Location: 10009..63201
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GL187_RS00055 (GL187_00055) | ftsH | 10009..11967 (+) | 1959 | WP_000744557.1 | ATP-dependent zinc metalloprotease FtsH | - |
| GL187_RS00060 (GL187_00060) | comX/comX2 | 12089..12568 (+) | 480 | WP_000588925.1 | sigma-70 family RNA polymerase sigma factor | Regulator |
| GL187_RS00095 (GL187_00095) | - | 18059..18905 (+) | 847 | Protein_13 | IS630 family transposase | - |
| GL187_RS00100 (GL187_00100) | - | 18940..19737 (-) | 798 | Protein_14 | transposase | - |
| GL187_RS00105 (GL187_00105) | comW | 20003..20239 (+) | 237 | WP_000939544.1 | sigma(X)-activator ComW | Regulator |
| GL187_RS00110 (GL187_00110) | - | 20470..21756 (+) | 1287 | WP_000205044.1 | adenylosuccinate synthase | - |
| GL187_RS00115 (GL187_00115) | tadA | 21957..22424 (+) | 468 | WP_000291870.1 | tRNA adenosine(34) deaminase TadA | - |
| GL187_RS10955 (GL187_00125) | - | 22633..23331 (-) | 699 | WP_001106362.1 | tyrosine-type recombinase/integrase | - |
| GL187_RS10960 (GL187_00130) | - | 23421..23768 (-) | 348 | WP_001839379.1 | hypothetical protein | - |
| GL187_RS00130 (GL187_00135) | - | 23829..24899 (-) | 1071 | WP_000401841.1 | type I restriction endonuclease | - |
| GL187_RS00135 (GL187_00140) | - | 24916..25296 (-) | 381 | WP_000170931.1 | ImmA/IrrE family metallo-endopeptidase | - |
| GL187_RS00140 (GL187_00145) | - | 25309..25572 (-) | 264 | WP_000285962.1 | type II toxin-antitoxin system RelE family toxin | - |
| GL187_RS00145 (GL187_00150) | - | 25572..25805 (-) | 234 | WP_000156419.1 | hypothetical protein | - |
| GL187_RS00150 (GL187_00155) | - | 25805..26173 (-) | 369 | WP_000464160.1 | helix-turn-helix domain-containing protein | - |
| GL187_RS00155 (GL187_00160) | - | 26745..26936 (+) | 192 | WP_001112859.1 | DNA-binding protein | - |
| GL187_RS00160 (GL187_00165) | - | 26959..27162 (+) | 204 | WP_001247549.1 | hypothetical protein | - |
| GL187_RS00165 (GL187_00170) | - | 27317..27484 (-) | 168 | WP_000024181.1 | YjzC family protein | - |
| GL187_RS00170 (GL187_00175) | - | 27489..27869 (+) | 381 | Protein_28 | autolysin | - |
| GL187_RS00175 (GL187_00180) | - | 28089..28268 (-) | 180 | WP_001209433.1 | hypothetical protein | - |
| GL187_RS00180 | - | 28410..28559 (-) | 150 | WP_001030863.1 | hypothetical protein | - |
| GL187_RS00185 (GL187_00185) | - | 28864..29307 (+) | 444 | WP_000701992.1 | dUTP diphosphatase | - |
| GL187_RS00190 (GL187_00190) | - | 29309..29824 (+) | 516 | WP_000691236.1 | histidine phosphatase family protein | - |
| GL187_RS00195 (GL187_00195) | radA | 29838..31199 (+) | 1362 | WP_074017595.1 | DNA repair protein RadA | Machinery gene |
| GL187_RS00200 (GL187_00200) | - | 31272..31769 (+) | 498 | WP_001809263.1 | beta-class carbonic anhydrase | - |
| GL187_RS00210 (GL187_00210) | - | 31794..32608 (+) | 815 | Protein_35 | PrsW family intramembrane metalloprotease | - |
| GL187_RS00215 (GL187_00215) | - | 32753..33721 (+) | 969 | WP_000010163.1 | ribose-phosphate diphosphokinase | - |
| GL187_RS00220 (GL187_00220) | - | 33855..34136 (-) | 282 | Protein_37 | transposase family protein | - |
| GL187_RS10940 | - | 34263..35170 (-) | 908 | Protein_38 | Rpn family recombination-promoting nuclease/putative transposase | - |
| GL187_RS00240 (GL187_00240) | polA | 35426..38059 (+) | 2634 | WP_088834530.1 | DNA polymerase I | - |
| GL187_RS00245 (GL187_00245) | - | 38144..38581 (+) | 438 | WP_061633093.1 | CoA-binding protein | - |
| GL187_RS10965 | - | 38622..39062 (+) | 441 | WP_000693179.1 | hypothetical protein | - |
| GL187_RS00255 (GL187_00255) | - | 39081..40091 (-) | 1011 | WP_000009171.1 | YeiH family protein | - |
| GL187_RS00260 (GL187_00260) | - | 40240..41409 (+) | 1170 | WP_000366342.1 | pyridoxal phosphate-dependent aminotransferase | - |
| GL187_RS00265 (GL187_00265) | recO | 41406..42176 (+) | 771 | WP_000616164.1 | DNA repair protein RecO | - |
| GL187_RS00270 (GL187_00270) | plsX | 42173..43165 (+) | 993 | WP_000717467.1 | phosphate acyltransferase PlsX | - |
| GL187_RS00275 (GL187_00275) | - | 43171..43404 (+) | 234 | WP_000136447.1 | acyl carrier protein | - |
| GL187_RS00280 (GL187_00280) | - | 43441..43740 (+) | 300 | Protein_47 | transposase family protein | - |
| GL187_RS00285 (GL187_00285) | blpU | 43943..44173 (+) | 231 | WP_001093487.1 | bacteriocin-like peptide BlpU | - |
| GL187_RS11340 | - | 44176..44301 (+) | 126 | WP_000346297.1 | PncF family bacteriocin immunity protein | - |
| GL187_RS10970 | - | 44712..44906 (+) | 195 | WP_000756776.1 | hypothetical protein | - |
| GL187_RS00290 (GL187_00290) | - | 44927..45820 (+) | 894 | WP_000343888.1 | helix-turn-helix domain-containing protein | - |
| GL187_RS00295 (GL187_00295) | - | 46363..46659 (+) | 297 | WP_000837726.1 | uberolysin/carnocyclin family circular bacteriocin | - |
| GL187_RS00300 (GL187_00300) | - | 46666..47802 (+) | 1137 | WP_000698828.1 | hypothetical protein | - |
| GL187_RS00305 (GL187_00305) | - | 47799..48281 (+) | 483 | WP_001232094.1 | stage II sporulation protein M | - |
| GL187_RS00310 (GL187_00310) | - | 48278..48874 (+) | 597 | WP_000687787.1 | ATP-binding cassette domain-containing protein | - |
| GL187_RS00315 (GL187_00315) | - | 48855..49346 (+) | 492 | WP_000671990.1 | hypothetical protein | - |
| GL187_RS00320 (GL187_00320) | comA | 49726..51879 (+) | 2154 | WP_000668280.1 | peptide cleavage/export ABC transporter ComA | Regulator |
| GL187_RS00325 (GL187_00325) | comB | 51892..53241 (+) | 1350 | WP_024477962.1 | competence pheromone export protein ComB | Regulator |
| GL187_RS00330 (GL187_00330) | purC | 53411..54118 (+) | 708 | WP_000043301.1 | phosphoribosylaminoimidazolesuccinocarboxamide synthase | - |
| GL187_RS00335 (GL187_00335) | - | 54175..57900 (+) | 3726 | WP_024477961.1 | phosphoribosylformylglycinamidine synthase | - |
| GL187_RS00340 (GL187_00340) | purF | 57993..59435 (+) | 1443 | WP_024477960.1 | amidophosphoribosyltransferase | - |
| GL187_RS00345 (GL187_00345) | purM | 59472..60494 (+) | 1023 | WP_000182575.1 | phosphoribosylformylglycinamidine cyclo-ligase | - |
| GL187_RS00350 (GL187_00350) | purN | 60491..61036 (+) | 546 | WP_000717506.1 | phosphoribosylglycinamide formyltransferase | - |
| GL187_RS00355 (GL187_00355) | - | 61120..61629 (+) | 510 | WP_000894018.1 | VanZ family protein | - |
| GL187_RS00360 (GL187_00360) | purH | 61654..63201 (+) | 1548 | WP_024477959.1 | bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase | - |
Sequence
Protein
Download Length: 449 a.a. Molecular weight: 49481.34 Da Isoelectric Point: 5.5618
>NTDB_id=403659 GL187_RS00325 WP_024477962.1 51892..53241(+) (comB) [Streptococcus pneumoniae strain 563]
MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEMSLSTRATVEPSRILANIQSTSNNRILVNHLEENKL
VKKGDLLVQYQEGAEGVQAESYASQLDMLKDQKKQLEYLQKSLQGGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQN
ETIASQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAIETGASLAGQNLAYSLYQSYKSQGEENPQTKVQAVAQVEAQIS
QLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKVGQELTLLAQKILEAESGKKVQGNLLDKGKVTASEDGVLH
LNPETSDSSMVAEGALLAQLYPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTEK
GNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE
MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEMSLSTRATVEPSRILANIQSTSNNRILVNHLEENKL
VKKGDLLVQYQEGAEGVQAESYASQLDMLKDQKKQLEYLQKSLQGGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQN
ETIASQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAIETGASLAGQNLAYSLYQSYKSQGEENPQTKVQAVAQVEAQIS
QLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKVGQELTLLAQKILEAESGKKVQGNLLDKGKVTASEDGVLH
LNPETSDSSMVAEGALLAQLYPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTEK
GNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE
Nucleotide
Download Length: 1350 bp
>NTDB_id=403659 GL187_RS00325 WP_024477962.1 51892..53241(+) (comB) [Streptococcus pneumoniae strain 563]
ATGAAACCAGAATTTTTAGAAAGTGCGGAGTTTTATAATCGTCGTTACCATAATTTTTCCAGTAGTGTGATTGTACCCAT
GGCCCTTCTGCTCGTGTTTTTACTTGGCTTTGCAACTGTTGCAGAGAAGGAGATGAGTTTGTCCACTAGAGCTACTGTCG
AACCTAGTCGTATCCTTGCAAATATCCAGTCAACTAGCAACAATCGTATTCTTGTCAATCATTTGGAAGAAAATAAGCTG
GTTAAGAAGGGGGATCTTTTGGTTCAATACCAAGAAGGGGCAGAGGGTGTCCAAGCGGAGTCCTATGCCAGTCAGTTGGA
CATGCTAAAGGATCAAAAAAAGCAATTGGAGTATCTGCAAAAGAGCCTGCAAGGAGGGGAGAACCACTTTCCAGAGGAGG
ATAAGTTTGGCTACCAAGCCACCTTTCGCGACTACATCAGTCAAGCAGGCAGTCTTAGGGCTAGTACATCGCAACAAAAT
GAGACCATCGCGTCCCAGAATGCAGCAGCTAGCCAAACCCAAGCCGAAATCGGCAACCTCATCAGTCAAACAGAGGCTAA
AATTCGCGATTACCAGACAGCTAAGTCAGCTATTGAAACAGGTGCTTCCTTGGCCGGTCAGAATCTAGCCTACTCTCTTT
ACCAGTCCTACAAGTCTCAGGGCGAAGAAAATCCCCAAACTAAGGTTCAGGCAGTTGCACAGGTTGAAGCACAGATTTCT
CAGTTAGAATCTAGTCTTGCTACTTACCGTGTCCAGTATGCAGGTTCAGGTACCCAGCAAGCCTATGCGTCAGGGTTAAG
CAGTCAATTGGAATCCCTTAAATCCCAACACTTGGCAAAGGTTGGTCAGGAATTGACCCTTCTAGCCCAGAAAATTTTGG
AGGCAGAGTCAGGTAAGAAGGTACAGGGAAATCTTTTAGACAAGGGGAAAGTTACGGCGAGTGAGGATGGGGTGCTTCAT
CTTAATCCTGAGACCAGTGATTCTAGCATGGTTGCAGAAGGTGCCCTACTAGCCCAACTTTATCCATCTTTGGAAAGAGA
AGGGAAAGCCAAACTCACAGCTTATCTAAGTTCAAAAGATGTAGCAAGAATCAAGGTCGGTGATTCTGTTCGCTATACTA
CGACTCATGATGCCGGGAATCAACTTTTCCTAGATTCTACTATTACAAGTATTGATGCGACAGCTACTAAGACTGAGAAA
GGGAATTTCTTTAAAATCGAGGCGGAGACTAATCTAACTTCGGAGCAGGCTGAAAAACTTAGGTATGGGGTGGAAGGCCG
TTTACAGATGATTACGGGCAAGAAAAGTTATCTACGTTATTATTTGGATCAATTTTTGAACAAAGAGTAA
ATGAAACCAGAATTTTTAGAAAGTGCGGAGTTTTATAATCGTCGTTACCATAATTTTTCCAGTAGTGTGATTGTACCCAT
GGCCCTTCTGCTCGTGTTTTTACTTGGCTTTGCAACTGTTGCAGAGAAGGAGATGAGTTTGTCCACTAGAGCTACTGTCG
AACCTAGTCGTATCCTTGCAAATATCCAGTCAACTAGCAACAATCGTATTCTTGTCAATCATTTGGAAGAAAATAAGCTG
GTTAAGAAGGGGGATCTTTTGGTTCAATACCAAGAAGGGGCAGAGGGTGTCCAAGCGGAGTCCTATGCCAGTCAGTTGGA
CATGCTAAAGGATCAAAAAAAGCAATTGGAGTATCTGCAAAAGAGCCTGCAAGGAGGGGAGAACCACTTTCCAGAGGAGG
ATAAGTTTGGCTACCAAGCCACCTTTCGCGACTACATCAGTCAAGCAGGCAGTCTTAGGGCTAGTACATCGCAACAAAAT
GAGACCATCGCGTCCCAGAATGCAGCAGCTAGCCAAACCCAAGCCGAAATCGGCAACCTCATCAGTCAAACAGAGGCTAA
AATTCGCGATTACCAGACAGCTAAGTCAGCTATTGAAACAGGTGCTTCCTTGGCCGGTCAGAATCTAGCCTACTCTCTTT
ACCAGTCCTACAAGTCTCAGGGCGAAGAAAATCCCCAAACTAAGGTTCAGGCAGTTGCACAGGTTGAAGCACAGATTTCT
CAGTTAGAATCTAGTCTTGCTACTTACCGTGTCCAGTATGCAGGTTCAGGTACCCAGCAAGCCTATGCGTCAGGGTTAAG
CAGTCAATTGGAATCCCTTAAATCCCAACACTTGGCAAAGGTTGGTCAGGAATTGACCCTTCTAGCCCAGAAAATTTTGG
AGGCAGAGTCAGGTAAGAAGGTACAGGGAAATCTTTTAGACAAGGGGAAAGTTACGGCGAGTGAGGATGGGGTGCTTCAT
CTTAATCCTGAGACCAGTGATTCTAGCATGGTTGCAGAAGGTGCCCTACTAGCCCAACTTTATCCATCTTTGGAAAGAGA
AGGGAAAGCCAAACTCACAGCTTATCTAAGTTCAAAAGATGTAGCAAGAATCAAGGTCGGTGATTCTGTTCGCTATACTA
CGACTCATGATGCCGGGAATCAACTTTTCCTAGATTCTACTATTACAAGTATTGATGCGACAGCTACTAAGACTGAGAAA
GGGAATTTCTTTAAAATCGAGGCGGAGACTAATCTAACTTCGGAGCAGGCTGAAAAACTTAGGTATGGGGTGGAAGGCCG
TTTACAGATGATTACGGGCAAGAAAAGTTATCTACGTTATTATTTGGATCAATTTTTGAACAAAGAGTAA
Domains
No domain identified.
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comB | Streptococcus pneumoniae TIGR4 |
99.555 |
100 |
0.996 |
| comB | Streptococcus pneumoniae Rx1 |
98.886 |
100 |
0.989 |
| comB | Streptococcus pneumoniae D39 |
98.886 |
100 |
0.989 |
| comB | Streptococcus pneumoniae R6 |
98.886 |
100 |
0.989 |
| comB | Streptococcus mitis SK321 |
94.655 |
100 |
0.947 |
| comB | Streptococcus mitis NCTC 12261 |
94.209 |
100 |
0.942 |
| comB | Streptococcus gordonii str. Challis substr. CH1 |
55.333 |
100 |
0.555 |