Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   GL186_RS00315 Genome accession   NZ_CP046358
Coordinates   49716..51740 (+) Length   674 a.a.
NCBI ID   WP_197097181.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 566     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 44716..56740
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GL186_RS00285 (GL186_00285) - 44917..45810 (+) 894 WP_000343888.1 helix-turn-helix domain-containing protein -
  GL186_RS00290 (GL186_00290) - 46353..46649 (+) 297 WP_000837726.1 uberolysin/carnocyclin family circular bacteriocin -
  GL186_RS00295 (GL186_00295) - 46656..47792 (+) 1137 WP_000698828.1 hypothetical protein -
  GL186_RS00300 (GL186_00300) - 47789..48271 (+) 483 WP_001232094.1 stage II sporulation protein M -
  GL186_RS00305 (GL186_00305) - 48268..48864 (+) 597 WP_000687787.1 ATP-binding cassette domain-containing protein -
  GL186_RS00310 (GL186_00310) - 48845..49336 (+) 492 WP_000671990.1 hypothetical protein -
  GL186_RS00315 (GL186_00315) comA 49716..51740 (+) 2025 WP_197097181.1 peptide cleavage/export ABC transporter ComA Regulator
  GL186_RS00320 (GL186_00320) comB 51753..53102 (+) 1350 WP_024477962.1 competence pheromone export protein ComB Regulator
  GL186_RS00325 (GL186_00325) purC 53272..53979 (+) 708 WP_000043301.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -

Sequence

Protein


Download         Length: 674 a.a.        Molecular weight: 75679.74 Da        Isoelectric Point: 5.9778

>NTDB_id=403229 GL186_RS00315 WP_197097181.1 49716..51740(+) (comA) [Streptococcus pneumoniae strain 566]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFAEEWTGVTLFMAPSPDYKPHKEQKNGLFSFIPI
LVKQRGLIANIVLATLLVTVINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYNTLLVYFTNPLENIIN
LQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLMKGDMTFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVGISGSGK
TTLAKMMVNFYDPSQGEISLGSVNLNQIDKKALRQYINYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIRED
IERMPLNYQTELTSDGAGISGGQRQRIALARALLTDAPVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAER
TEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS

Nucleotide


Download         Length: 2025 bp        

>NTDB_id=403229 GL186_RS00315 WP_197097181.1 49716..51740(+) (comA) [Streptococcus pneumoniae strain 566]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAAGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGTTATTATTTTTTGGCTCACTTGCGAGAATTGGCTAAGACGACCATGGATGGGACGACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGTTTTGAGACGCGAGCCATTAAGGCGGATATGACGCTTTTTGACTTGCCGGATTTG
ACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAAGGGAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGATAG
CATTCATATTGCCGACCCAGATCCTGGGGTGAAATTGACTAAACTGCCACGTGAGCGTTTTGCGGAAGAATGGACAGGAG
TGACTCTTTTTATGGCACCTAGTCCAGACTACAAGCCTCATAAGGAACAAAAAAATGGTCTGTTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAATATCGTTTTGGCAACACTCTTGGTAACCGTGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACACTAGGGATTATTTCTATTGGGCTAGTCA
TCGTCTACATCCTCCAGCAAATCTTGTCTTACGCTCAGGAGTATCTCTTGCTTGTTTTGGGGCAACGCTTGTCGATTGAC
GTGATTTTGTCCTATATCAAGCATGTTTTTCACCTCCCTATGTCCTTCTTTGCGACACGCAGGACAGGGGAGATCGTGTC
TCGTTTTACAGATGCTAACAGTATCATCGATGCGCTGGCTTCGACCATCCTTTCGATTTTCCTAGATGTGTCAACGGTTG
TCATTATTTCCCTTGTTCTATTTTCACAAAATACCAATCTCTTTTTCATGACTTTATTGGCGCTTCCTATCTACACAGTG
ATTATCTTTGCCTTTATGAAGCCGTTTGAAAAGATGAATCGGGATACCATGGAAGCCAATGCGGTTCTGTCTTCTTCTAT
CATTGAGGACATCAACGGTATTGAGACTATCAAGTCCTTGACCAGTGAAAGTCAGCGTTACCAAAAAATTGACAAGGAAT
TTGTGGATTATCTGAAGAAATCCTTTACCTATAATACCTTGCTGGTTTACTTTACCAATCCTTTGGAAAATATCATCAAT
CTGCAAACCAAGCTTCAGACAGCGCAGGTTGCCAATAACCGTCTAAATGAAGTGTATCTAGTAGCTTCTGAGTTTGAGGA
GAAGAAAACAGTTGAGGATTTGAGCTTGATGAAGGGAGATATGACCTTCAAGCAGGTTCATTACAAGTATGGCTATGGTC
GAGACGTCTTGTCGGATATCAATTTAACCGTTCCCCAAGGGTCTAAGGTGGCTTTTGTGGGGATTTCAGGGTCAGGTAAG
ACGACTTTGGCCAAGATGATGGTTAATTTTTACGACCCAAGTCAAGGGGAGATTAGTCTGGGTAGTGTCAATCTCAATCA
GATTGATAAAAAAGCCCTGCGCCAGTACATCAACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGAGA
ATCTTCTTTTGGGAGCCAAGGAGGGGACGACACAGGAAGATATCTTACGGGCGGTCGAATTGGCAGAGATTCGAGAGGAT
ATCGAGCGCATGCCACTGAATTATCAGACAGAATTGACTTCGGATGGGGCAGGGATTTCAGGTGGTCAACGTCAGAGAAT
CGCTTTGGCGCGTGCTCTCTTGACAGATGCGCCGGTCTTGATTTTGGATGAGGCGACTAGCAGTTTGGATATTTTGACAG
AGAAGCGGATTGTCGATAATCTCATGGCTTTGGACAAGACCTTGATTTTCATTGCTCACCGCTTGACTATTGCTGAGCGG
ACAGAGAAGGTGGTTGTCTTGGATCAGGGCAAGATTGTCGAAGAAGGAAAGCATGCTGATTTGCTTGCACAGGGAGGCTT
TTACGCCCATTTGGTCAATAGCTAG

Domains

Predicted by InterproScan.

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter transmembrane region (ABC_membrane)

(170-387)

ABC transporter (ABC_tran)

(457-607)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus pneumoniae Rx1

93.445

100

0.994
  comA Streptococcus pneumoniae D39

93.445

100

0.994
  comA Streptococcus pneumoniae R6

93.445

100

0.994
  comA Streptococcus pneumoniae TIGR4

93.305

100

0.993
  comA Streptococcus mitis SK321

92.469

100

0.984
  comA Streptococcus mitis NCTC 12261

92.469

100

0.984
  comA Streptococcus gordonii str. Challis substr. CH1

76.29

100

0.812
  comA/nlmT Streptococcus mutans UA159

61.506

100

0.654

Multiple sequence alignment