Detailed information NTG0402993

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: GLO74_RS11480
• Genome accession: NZ_CP046354
• Coordinates: 1645777..1646364 (+)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain 310
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1640777..1651364

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GLO74_RS08390 (GLO74_08510)	-	1641037..1641726 (-)	690	WP_000760532.1	CPBP family intramembrane glutamic endopeptidase	-
GLO74_RS08395 (GLO74_08515)	-	1641778..1642161 (-)	384	WP_000877381.1	hypothetical protein	-
GLO74_RS08400 (GLO74_08520)	-	1642790..1643148 (-)	359	Protein_1624	immunity protein	-
GLO74_RS08405 (GLO74_08530)	-	1643629..1643748 (-)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
GLO74_RS11515	-	1643751..1643816 (-)	66	Protein_1626	ComC/BlpC family peptide pheromone/bacteriocin	-
GLO74_RS08410 (GLO74_08535)	cipB	1643852..1644001 (-)	150	WP_001809846.1	bacteriocin-like peptide BlpO	Regulator
GLO74_RS08415 (GLO74_08540)	blpK	1644245..1644493 (-)	249	WP_000379965.1	bacteriocin-like peptide BlpK	-
GLO74_RS08420 (GLO74_08545)	blpJ	1644562..1644831 (-)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
GLO74_RS08425 (GLO74_08550)	blpI	1645298..1645495 (-)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
GLO74_RS11480	comA/nlmT	1645777..1646364 (+)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
GLO74_RS08435 (GLO74_08555)	comA/nlmT	1646291..1647934 (+)	1644	WP_078133412.1	peptide cleavage/export ABC transporter	Regulator
GLO74_RS08440 (GLO74_08560)	-	1647945..1649306 (+)	1362	WP_197097175.1	bacteriocin secretion accessory protein	-
GLO74_RS08445 (GLO74_08565)	blpC	1649363..1649491 (+)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
GLO74_RS08450 (GLO74_08570)	-	1649562..1650902 (-)	1341	WP_001017642.1	sensor histidine kinase	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=402993 GLO74_RS11480 WP_000205166.1 1645777..1646364(+) (comA/nlmT) [Streptococcus pneumoniae strain 310]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=402993 GLO74_RS11480 WP_000205166.1 1645777..1646364(+) (comA/nlmT) [Streptococcus pneumoniae strain 310]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497