Detailed information NTG0402970

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: GLO74_RS06525
• Genome accession: NZ_CP046354
• Coordinates: 1261119..1261769 (-)
• Length: 216 a.a.
• NCBI ID: WP_024477778.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 310
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1256119..1266769

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GLO74_RS06505 (GLO74_06590)	-	1256720..1257904 (-)	1185	WP_000655960.1	ABC transporter permease	-
GLO74_RS06510 (GLO74_06595)	-	1257908..1258495 (-)	588	WP_000939895.1	ATP-binding cassette domain-containing protein	-
GLO74_RS06515 (GLO74_06600)	-	1258528..1258716 (-)	189	WP_001808514.1	hypothetical protein	-
GLO74_RS06520 (GLO74_06605)	comEC/celB	1258895..1261135 (-)	2241	WP_024477777.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
GLO74_RS06525 (GLO74_06610)	comEA/celA/cilE	1261119..1261769 (-)	651	WP_024477778.1	ComEA family DNA-binding protein	Machinery gene
GLO74_RS06530 (GLO74_06615)	-	1261837..1262406 (-)	570	WP_000443774.1	GNAT family N-acetyltransferase	-
GLO74_RS11020	ald	1262583..1263694 (+)	1112	Protein_1249	alanine dehydrogenase	-
GLO74_RS06550 (GLO74_06635)	-	1263995..1264320 (-)	326	Protein_1250	TfoX/Sxy family protein	-
GLO74_RS06555 (GLO74_06640)	-	1264323..1264824 (-)	502	Protein_1251	GNAT family N-acetyltransferase	-
GLO74_RS06565 (GLO74_06650)	-	1265017..1265985 (-)	969	WP_000658183.1	PhoH family protein	-
GLO74_RS06570 (GLO74_06655)	-	1266071..1266286 (-)	216	WP_001232085.1	YozE family protein	-

Sequence

Protein

• Length: 216 a.a.
• Molecular weight: 23243.72 Da
• Isoelectric Point: 6.0746

>NTDB_id=402970 GLO74_RS06525 WP_024477778.1 1261119..1261769(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain 310]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDLVSEKEVKKEEKEEPLEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGLGTASSISKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD

Nucleotide

• Length: 651 bp

>NTDB_id=402970 GLO74_RS06525 WP_024477778.1 1261119..1261769(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain 310]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGCGGATT
TTTCCTGCTAAAGCCAGCTCCACAAACACCTGTCAAAGAAACGAATTTGCAGGCTGAAGTTGCAGCTGTTTCCAAGGATT
TGGTATCCGAAAAGGAAGTGAAGAAGGAAGAGAAGGAAGAACCCCTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGCCAACAGACTGGTTTGGGGACAGCTTCTTCAATAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAACTCAAGAAGGTCTCTGGCATTGGTGGCAAAACAATAGAAAAGCTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

• SLBB domain (SLBB) (76-126)

• Helix-hairpin-helix motif (HHH_3) (151-214)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus pneumoniae Rx1	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae D39	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae R6	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	97.685	100	0.977
comEA/celA/cilE	Streptococcus mitis NCTC 12261	96.759	100	0.968
comEA/celA/cilE	Streptococcus mitis SK321	90.741	100	0.907
comEA	Lactococcus lactis subsp. cremoris KW2	41.333	100	0.431
comEA	Latilactobacillus sakei subsp. sakei 23K	33.476	100	0.361