Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SOR_RS05835 Genome accession   NC_015291
Coordinates   1169405..1170079 (-) Length   224 a.a.
NCBI ID   WP_000590641.1    Uniprot ID   F2QDY4
Organism   Streptococcus oralis Uo5     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1164405..1175079
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SOR_RS05810 (SOR_1190) - 1164540..1165469 (-) 930 WP_000411175.1 peptidase U32 family protein -
  SOR_RS05815 (SOR_1191) - 1165595..1166275 (-) 681 WP_000209233.1 ABC transporter ATP-binding protein -
  SOR_RS05820 (SOR_1192) - 1166289..1167344 (-) 1056 WP_000280276.1 ABC transporter permease -
  SOR_RS05825 (SOR_1193) - 1167729..1168013 (+) 285 WP_001276163.1 DUF3270 domain-containing protein -
  SOR_RS05830 (SOR_1194) ciaH 1168078..1169415 (-) 1338 WP_013670240.1 sensor histidine kinase Regulator
  SOR_RS05835 (SOR_1195) ciaR 1169405..1170079 (-) 675 WP_000590641.1 two-component system response regulator CiaR Regulator
  SOR_RS05840 (SOR_1196) - 1170189..1172735 (-) 2547 WP_001149134.1 M1 family metallopeptidase -
  SOR_RS05845 (SOR_1197) - 1172856..1173296 (-) 441 WP_013670241.1 ASCH domain-containing protein -
  SOR_RS05850 (SOR_1198) - 1173238..1174140 (-) 903 WP_001245873.1 putative PEP-binding protein -
  SOR_RS05855 (SOR_1199) - 1174118..1174618 (-) 501 WP_000403330.1 NUDIX hydrolase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25478.30 Da        Isoelectric Point: 4.3011

>NTDB_id=40202 SOR_RS05835 WP_000590641.1 1169405..1170079(-) (ciaR) [Streptococcus oralis Uo5]
MIKILLVEDDLGLSNSVFDFLDNFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGDVIVNLSTNEVKVEDTPVELLGKEFELLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFAENLQTLRSVGYILKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=40202 SOR_RS05835 WP_000590641.1 1169405..1170079(-) (ciaR) [Streptococcus oralis Uo5]
ATGATAAAAATCTTATTAGTAGAAGATGACCTGGGTCTGTCAAACTCAGTATTTGACTTTTTAGATAATTTTGCAGATGT
CATGCAGGTCTTTGATGGAGAAGAAGGTCTCTACGAAGCAGAAAGTGGCGTTTATGACTTGATTCTGCTTGACCTGATGT
TGCCTGAAAAAAATGGCTTCCAAGTTTTGAAAGAATTGCGTGAAAAAGGAATTACGACACCAGTCCTTATCATGACCGCT
AAGGAAAGTTTGGATGACAAGGGACATGGTTTTGAGTTAGGAGCGGATGACTACCTCACCAAACCTTTCTACCTAGAAGA
ACTTAAAATGCGGATTCAAGCCCTTCTCAAACGTTCAGGTAAGTTTAATGAAAACACCTTGACCTATGGGGATGTTATCG
TCAATCTTTCAACGAATGAAGTAAAAGTGGAAGATACTCCTGTGGAACTGCTCGGAAAAGAGTTTGAGTTATTGGTTTAC
TTCCTTCAAAATCAAAATGTCATTCTTCCCAAGACACAGATTTTTGACCGTCTATGGGGATTTGATAGCGATACGACGAT
TTCCGTTGTAGAAGTCTATGTCTCAAAAGTTCGTAAGAAATTGAAGGGAACAGCCTTTGCTGAAAATCTTCAAACCTTGC
GTAGTGTCGGGTATATTTTAAAAGATGTTCAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB F2QDY4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae TIGR4

96.429

100

0.964
  ciaR Streptococcus pneumoniae D39

96.429

100

0.964
  ciaR Streptococcus pneumoniae R6

96.429

100

0.964
  ciaR Streptococcus pneumoniae Rx1

96.429

100

0.964
  ciaR Streptococcus mutans UA159

87.054

100

0.871
  vicR Streptococcus mutans UA159

36.481

100

0.379
  covR Lactococcus lactis subsp. lactis strain DGCC12653

35.841

100

0.362

Multiple sequence alignment