Detailed information NTG0401534

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: GKC13_RS08165
• Genome accession: NZ_CP046134
• Coordinates: 1588946..1589845 (-)
• Length: 299 a.a.
• NCBI ID: WP_014607953.1
• Uniprot ID: A0AAN1ZWJ0
• Organism: Streptococcus thermophilus strain MAG_rmk202_sterm
• Function: activate transcription of comX; activate transcription of comS (predicted from homology) Competence regulation

Genomic Context

Location: 1583946..1594845

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GKC13_RS08145 (GKC13_08250)	-	1583947..1584462 (-)	516	WP_002949547.1	AmiS/UreI family transporter	-
GKC13_RS10245	-	1585143..1585763 (+)	621	WP_232085704.1	DUF4153 domain-containing protein	-
GKC13_RS10555	-	1585688..1586035 (+)	348	WP_232085744.1	DUF4153 domain-containing protein	-
GKC13_RS08155 (GKC13_08260)	-	1586251..1586568 (-)	318	WP_179970762.1	DUF805 domain-containing protein	-
GKC13_RS10560 (GKC13_08265)	-	1586676..1588771 (-)	2096	Protein_1617	peptide cleavage/export ABC transporter	-
GKC13_RS08165 (GKC13_08270)	comR	1588946..1589845 (-)	900	WP_014607953.1	helix-turn-helix domain-containing protein	Regulator
GKC13_RS08170 (GKC13_08275)	-	1590040..1590690 (-)	651	WP_011225447.1	phosphatase PAP2 family protein	-
GKC13_RS08175 (GKC13_08280)	-	1590693..1591250 (-)	558	WP_002949523.1	ECF transporter S component	-
GKC13_RS08180 (GKC13_08285)	-	1591562..1592071 (-)	510	WP_014607952.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
GKC13_RS08185 (GKC13_08290)	trkA	1592360..1593709 (+)	1350	WP_207559738.1	Trk system potassium transporter TrkA	-

Sequence

Protein

• Length: 299 a.a.
• Molecular weight: 35289.70 Da
• Isoelectric Point: 5.0061

>NTDB_id=401534 GKC13_RS08165 WP_014607953.1 1588946..1589845(-) (comR) [Streptococcus thermophilus strain MAG_rmk202_sterm]
MNIKDSIGLRIKTERERQQMSREVLCLDGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYYE
MKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFST
NDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTVVDKALAVIENS
QLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKAGKLADGL

Nucleotide

• Length: 900 bp

>NTDB_id=401534 GKC13_RS08165 WP_014607953.1 1588946..1589845(-) (comR) [Streptococcus thermophilus strain MAG_rmk202_sterm]
TTGAACATAAAAGACAGCATTGGACTAAGAATCAAAACTGAGCGTGAACGCCAACAGATGTCACGTGAAGTGCTATGTTT
AGATGGTGCGGAATTGACTGTTCGCCAGTTAATTCGTATTGAAAAGGGGGAGTCTCTCCCGTCTTTAGATAGATTATCGT
ATATTGCTAAACGTTTAGGAAAAAGTATGACAGAGTTATTGGATCAAGACAATATTACCATTCCTGACGAATATTATGAA
ATGAAGAATCGTTTGATTAAGTTTCCAACGTACAGAAACCCTGACAGAATAAAGTCTAAACTTACTTTGATTGAGGAAGT
CTATGAGAAATTTTTTGATATTCTTCCAGAAGAAGAATTATTAACTCTAGACATTCTCGAAAATATATTGAGTTTTACTA
GCTGGGAGGAGAGTCCAAAAGTTGAGGAGATATATGAAGACTTGTTTGAACAAGTCAAAAGGAAGAGGAAATTCTCAACT
AACGATTTATTAGTCATTGACTATTATTTCTTTCATCTTTATGGGAGAAAACAGTATGACAAAAAACTATTTGAAAGAAT
TATAAAGAGAGTATTAAATCAGGAAATTTGGACAGATGATGTTTACAATATTGTTTTATTTAATGATTTGATGGCTATTG
CTGCTTTAAAGATTTTTCACAATTCCTTCTCAGACTTCTTAACAGTTGTGGATAAAGCCTTAGCTGTCATAGAAAACTCA
CAATTATATAGCTACAAGCCTAGTGTTTTTGTACTTAAGGCTAAATATGAACTTCTGCATAAAGAAAACAAGAAAGAGGC
TGCAGAGAATTATGATAAGGCCATAATGTTTGCTTCCGTTTTGGAAGACTCGGTTTTAGAGGAAAGTATAAAGGCAGGAA
AATTGGCAGATGGTTTATAG

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (11-66)

• ComR tetratricopeptide (ComR_TPR) (75-292)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus thermophilus LMG 18311	99.666	100	0.997
comR	Streptococcus thermophilus LMD-9	98.997	100	0.99
comR	Streptococcus salivarius strain HSISS4	94.983	100	0.95
comR	Streptococcus salivarius SK126	94.314	100	0.943
comR/comR2	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421
comR/comR1	Streptococcus sobrinus strain NIDR 6715-7	41.806	100	0.418