Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   HTZ88_RS01510 Genome accession   NZ_CP054418
Coordinates   270728..271417 (+) Length   229 a.a.
NCBI ID   WP_014973796.1    Uniprot ID   K0DCF6
Organism   Leuconostoc carnosum strain 4010     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 265728..276417
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HTZ88_RS01490 (HTZ88_01490) leuD 266479..267063 (+) 585 WP_014973792.1 3-isopropylmalate dehydratase small subunit -
  HTZ88_RS01495 (HTZ88_01495) - 267074..268360 (+) 1287 WP_014973793.1 MFS transporter -
  HTZ88_RS01500 (HTZ88_01500) - 268378..269166 (+) 789 WP_041773140.1 L-threonylcarbamoyladenylate synthase -
  HTZ88_RS01505 (HTZ88_01505) - 269458..270483 (+) 1026 WP_014973795.1 HoxN/HupN/NixA family nickel/cobalt transporter -
  HTZ88_RS01510 (HTZ88_01510) ciaR 270728..271417 (+) 690 WP_014973796.1 response regulator transcription factor Regulator
  HTZ88_RS01515 (HTZ88_01515) - 271410..272693 (+) 1284 WP_014973797.1 cell wall metabolism sensor histidine kinase WalK -
  HTZ88_RS01520 (HTZ88_01520) htrA 272749..273615 (+) 867 WP_014973798.1 S1C family serine protease Regulator
  HTZ88_RS01525 (HTZ88_01525) - 273697..274695 (-) 999 WP_014973799.1 AI-2E family transporter -
  HTZ88_RS01530 (HTZ88_01530) - 274865..275191 (-) 327 WP_014973800.1 thioredoxin family protein -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 25752.57 Da        Isoelectric Point: 4.5433

>NTDB_id=399653 HTZ88_RS01510 WP_014973796.1 270728..271417(+) (ciaR) [Leuconostoc carnosum strain 4010]
MAKAIKILLIEDDVNLADNIVGFLQDFVDVNVVTNGLDGEFEGQESPYDLIISDLMLPGENGLEIIKHLREKGIETPILI
LTAKSSLDDKIEGFNVGADDYLTKPFHREELLVRVKALLRRTGVYSEDNMIVVGDVLINLENRGVQVHGQTVKLVGKEFD
ILTYLAQNKNIIVTRDQIFDRVWGIDSDTTINVVNIYLNNLRRKLEAVGQNHLIKTLRNIGFILEVDNA

Nucleotide


Download         Length: 690 bp        

>NTDB_id=399653 HTZ88_RS01510 WP_014973796.1 270728..271417(+) (ciaR) [Leuconostoc carnosum strain 4010]
ATGGCAAAAGCAATTAAAATTTTATTAATCGAAGATGATGTGAACTTAGCTGATAATATTGTTGGGTTCTTACAGGATTT
TGTAGATGTTAATGTGGTCACAAATGGCTTGGATGGTGAGTTTGAGGGACAAGAATCACCATATGATTTAATTATTTCTG
ATTTAATGTTGCCAGGTGAAAATGGTTTGGAAATTATTAAGCATTTGAGGGAAAAGGGTATCGAGACACCTATTTTGATT
TTGACAGCCAAAAGCTCATTGGATGATAAAATTGAAGGCTTCAATGTGGGGGCCGATGACTACCTAACGAAGCCTTTTCA
CCGTGAAGAATTATTAGTCCGAGTTAAAGCTTTACTACGTCGTACAGGTGTTTATTCAGAAGATAATATGATTGTCGTTG
GTGATGTGTTGATTAATTTAGAAAATCGTGGTGTTCAAGTTCATGGGCAGACGGTTAAGTTAGTCGGAAAAGAATTTGAT
ATTTTAACTTATTTGGCACAAAACAAAAATATTATTGTCACACGTGATCAAATATTTGATCGTGTATGGGGGATTGATTC
TGATACAACAATCAATGTGGTAAATATTTATTTGAACAATTTGCGACGTAAGTTAGAAGCGGTCGGACAAAATCATTTGA
TTAAAACGTTGCGTAATATTGGCTTTATTTTAGAGGTAGACAATGCCTAA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(7-115)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(149-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB K0DCF6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

51.584

96.507

0.498
  ciaR Streptococcus pneumoniae D39

51.584

96.507

0.498
  ciaR Streptococcus pneumoniae R6

51.584

96.507

0.498
  ciaR Streptococcus pneumoniae TIGR4

51.584

96.507

0.498
  ciaR Streptococcus mutans UA159

50.679

96.507

0.489
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.286

97.817

0.384
  micA Streptococcus pneumoniae Cp1015

36.207

100

0.367
  vicR Streptococcus mutans UA159

35.776

100

0.362