Detailed information
Bioinformatically predicted
Overview
| Name | mecA | Type | Regulator |
| Locus tag | GFB63_RS05575 | Genome accession | NZ_CP045596 |
| Coordinates | 1077605..1078354 (+) | Length | 249 a.a. |
| NCBI ID | WP_011680667.1 | Uniprot ID | Q03MN5 |
| Organism | Streptococcus thermophilus strain TK-P3A | ||
| Function | degradation of ComX (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1007597..1087001 | 1077605..1078354 | within | 0 |
Gene organization within MGE regions
Location: 1007597..1087001
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GFB63_RS05270 (GFB63_05415) | - | 1011724..1011915 (+) | 192 | WP_100262165.1 | calcium-binding protein | - |
| GFB63_RS05275 (GFB63_05420) | - | 1011899..1012450 (+) | 552 | WP_193838168.1 | hypothetical protein | - |
| GFB63_RS05280 (GFB63_05425) | - | 1012500..1017950 (+) | 5451 | Protein_997 | DEAD/DEAH box helicase family protein | - |
| GFB63_RS05285 (GFB63_05435) | - | 1018460..1020238 (+) | 1779 | WP_111679146.1 | reverse transcriptase/maturase family protein | - |
| GFB63_RS05290 (GFB63_05440) | - | 1020331..1021719 (+) | 1389 | Protein_999 | helicase-related protein | - |
| GFB63_RS05295 (GFB63_05445) | - | 1021790..1022089 (+) | 300 | WP_111679148.1 | DUF5962 family protein | - |
| GFB63_RS05300 (GFB63_05450) | - | 1022103..1022393 (+) | 291 | WP_111679150.1 | DUF5966 family protein | - |
| GFB63_RS05305 (GFB63_05455) | - | 1022687..1024309 (+) | 1623 | WP_111679152.1 | AAA family ATPase | - |
| GFB63_RS05310 (GFB63_05460) | - | 1024306..1025634 (+) | 1329 | WP_111679154.1 | HNH endonuclease signature motif containing protein | - |
| GFB63_RS05315 (GFB63_05465) | - | 1025897..1026535 (+) | 639 | WP_111679156.1 | peptidylprolyl isomerase | - |
| GFB63_RS05320 (GFB63_05470) | - | 1026575..1027651 (+) | 1077 | WP_193838170.1 | toprim domain-containing protein | - |
| GFB63_RS05325 (GFB63_05475) | - | 1027705..1027932 (+) | 228 | WP_111679158.1 | DUF5965 family protein | - |
| GFB63_RS05330 (GFB63_05480) | - | 1027929..1028318 (+) | 390 | WP_039670295.1 | DUF5945 family protein | - |
| GFB63_RS05335 (GFB63_05485) | - | 1028365..1028655 (+) | 291 | WP_162173398.1 | hypothetical protein | - |
| GFB63_RS05340 (GFB63_05490) | - | 1028791..1030129 (+) | 1339 | Protein_1009 | IS1182 family transposase | - |
| GFB63_RS10555 | pezA | 1030312..1030788 (+) | 477 | WP_039670297.1 | type II toxin-antitoxin system antitoxin PezA | - |
| GFB63_RS05345 (GFB63_05495) | pezT | 1030788..1031564 (+) | 777 | WP_111679164.1 | type II toxin-antitoxin system toxin PezT | - |
| GFB63_RS05350 (GFB63_05500) | - | 1031548..1032357 (+) | 810 | WP_039670299.1 | Hachiman antiphage defense system protein HamA | - |
| GFB63_RS05355 (GFB63_05505) | - | 1032354..1035437 (+) | 3084 | WP_111679166.1 | DEAD/DEAH box helicase | - |
| GFB63_RS05360 (GFB63_05510) | - | 1035462..1036358 (+) | 897 | WP_193838435.1 | restriction endonuclease | - |
| GFB63_RS05365 (GFB63_05515) | - | 1036699..1037061 (+) | 363 | WP_039671040.1 | SAG1252 family conjugative relaxosome accessory protein | - |
| GFB63_RS05370 (GFB63_05520) | - | 1037064..1037429 (+) | 366 | WP_039671039.1 | plasmid mobilization protein | - |
| GFB63_RS05375 (GFB63_05525) | - | 1037416..1039299 (+) | 1884 | WP_193838171.1 | SAG1250 family conjugative relaxase | - |
| GFB63_RS05380 (GFB63_05535) | - | 1039826..1040167 (+) | 342 | WP_024404826.1 | LytTR family DNA-binding domain-containing protein | - |
| GFB63_RS05385 (GFB63_05540) | comE/blpR | 1040169..1040909 (+) | 741 | WP_193838172.1 | response regulator transcription factor | Regulator |
| GFB63_RS05390 (GFB63_05545) | - | 1040920..1042260 (+) | 1341 | WP_193838173.1 | sensor histidine kinase | - |
| GFB63_RS05395 (GFB63_05550) | - | 1042308..1042463 (-) | 156 | WP_096811960.1 | ComC/BlpC family leader-containing pheromone/bacteriocin | - |
| GFB63_RS05400 (GFB63_05555) | - | 1042562..1043923 (-) | 1362 | WP_193838174.1 | bacteriocin secretion accessory protein | - |
| GFB63_RS05405 (GFB63_05560) | comA/nlmT | 1043935..1046088 (-) | 2154 | WP_193838175.1 | peptide cleavage/export ABC transporter | Regulator |
| GFB63_RS05410 (GFB63_05565) | - | 1046386..1046643 (+) | 258 | WP_039671027.1 | Blp family class II bacteriocin | - |
| GFB63_RS05415 (GFB63_05570) | - | 1046660..1046854 (+) | 195 | WP_039671026.1 | class IIb bacteriocin, lactobin A/cerein 7B family | - |
| GFB63_RS05420 (GFB63_05575) | - | 1047456..1048806 (+) | 1351 | Protein_1026 | IS3 family transposase | - |
| GFB63_RS05425 (GFB63_05580) | - | 1049230..1050255 (+) | 1026 | WP_193838176.1 | thioredoxin fold domain-containing protein | - |
| GFB63_RS05430 (GFB63_05585) | - | 1050259..1050954 (+) | 696 | WP_111679181.1 | CPBP family intramembrane glutamic endopeptidase | - |
| GFB63_RS05435 | - | 1050984..1051136 (+) | 153 | WP_162173399.1 | hypothetical protein | - |
| GFB63_RS05440 (GFB63_05590) | - | 1051322..1051717 (+) | 396 | WP_111679183.1 | sigma-70 family RNA polymerase sigma factor | - |
| GFB63_RS05445 (GFB63_05595) | - | 1052035..1052175 (+) | 141 | WP_044775899.1 | hypothetical protein | - |
| GFB63_RS05450 (GFB63_05600) | - | 1052274..1053848 (+) | 1575 | WP_111679185.1 | recombinase family protein | - |
| GFB63_RS05455 (GFB63_05605) | - | 1053848..1055467 (+) | 1620 | WP_111679187.1 | recombinase family protein | - |
| GFB63_RS05460 (GFB63_05610) | - | 1055460..1056899 (+) | 1440 | WP_133264091.1 | recombinase family protein | - |
| GFB63_RS05465 (GFB63_05615) | - | 1057010..1057321 (+) | 312 | Protein_1035 | NUDIX domain-containing protein | - |
| GFB63_RS05470 (GFB63_05620) | prmA | 1057321..1058274 (+) | 954 | WP_084828438.1 | 50S ribosomal protein L11 methyltransferase | - |
| GFB63_RS05475 (GFB63_05625) | - | 1058275..1059018 (+) | 744 | WP_084825734.1 | 16S rRNA (uracil(1498)-N(3))-methyltransferase | - |
| GFB63_RS05480 (GFB63_05630) | - | 1059202..1061778 (+) | 2577 | Protein_1038 | bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase | - |
| GFB63_RS05485 (GFB63_05635) | nrdI | 1061765..1062223 (-) | 459 | WP_084828439.1 | class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI | - |
| GFB63_RS05490 (GFB63_05640) | - | 1062392..1064611 (+) | 2220 | WP_084828440.1 | bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | - |
| GFB63_RS05495 (GFB63_05645) | dtd | 1064624..1065067 (+) | 444 | WP_084828441.1 | D-aminoacyl-tRNA deacylase | - |
| GFB63_RS10915 (GFB63_05650) | - | 1065508..1065792 (+) | 285 | WP_065972829.1 | glycoside hydrolase family 66 protein | - |
| GFB63_RS10920 | - | 1065722..1065970 (+) | 249 | Protein_1043 | glycoside hydrolase family 66 protein | - |
| GFB63_RS10565 | - | 1066057..1066236 (+) | 180 | WP_223899617.1 | hypothetical protein | - |
| GFB63_RS10570 | - | 1066432..1066650 (+) | 219 | WP_223899612.1 | hypothetical protein | - |
| GFB63_RS10575 | - | 1066669..1067043 (+) | 375 | WP_223899613.1 | hypothetical protein | - |
| GFB63_RS05515 (GFB63_05665) | ilvA | 1067344..1068594 (+) | 1251 | WP_084828442.1 | threonine ammonia-lyase IlvA | - |
| GFB63_RS05520 (GFB63_05670) | def | 1068755..1069369 (-) | 615 | WP_002949244.1 | peptide deformylase | - |
| GFB63_RS05525 (GFB63_05675) | - | 1069463..1070101 (-) | 639 | WP_100273462.1 | cyclic nucleotide-binding domain-containing protein | - |
| GFB63_RS05530 (GFB63_05680) | - | 1070208..1071371 (+) | 1164 | WP_100273463.1 | MFS transporter | - |
| GFB63_RS05535 (GFB63_05685) | rpsO | 1071520..1071789 (+) | 270 | WP_002949247.1 | 30S ribosomal protein S15 | - |
| GFB63_RS05540 (GFB63_05690) | - | 1072019..1072600 (-) | 582 | WP_011225359.1 | VanZ family protein | - |
| GFB63_RS05545 | - | 1073169..1073339 (+) | 171 | WP_193838177.1 | hypothetical protein | - |
| GFB63_RS05550 (GFB63_05695) | - | 1073426..1073533 (+) | 108 | WP_193838178.1 | LPXTG cell wall anchor domain-containing protein | - |
| GFB63_RS05555 (GFB63_05700) | - | 1073621..1074361 (-) | 741 | WP_179972549.1 | amino acid ABC transporter ATP-binding protein | - |
| GFB63_RS05560 (GFB63_05705) | - | 1074361..1075911 (-) | 1551 | WP_193838179.1 | ABC transporter substrate-binding protein/permease | - |
| GFB63_RS05565 (GFB63_05710) | - | 1076114..1076968 (+) | 855 | WP_011680666.1 | undecaprenyl-diphosphate phosphatase | - |
| GFB63_RS05570 (GFB63_05715) | - | 1077020..1077328 (-) | 309 | WP_306496352.1 | DUF3021 family protein | - |
| GFB63_RS05575 (GFB63_05720) | mecA | 1077605..1078354 (+) | 750 | WP_011680667.1 | adaptor protein MecA | Regulator |
| GFB63_RS05580 (GFB63_05725) | - | 1078358..1079515 (+) | 1158 | WP_014621088.1 | glycosyltransferase family 4 protein | - |
| GFB63_RS05585 (GFB63_05730) | sufC | 1079676..1080446 (+) | 771 | WP_002947634.1 | Fe-S cluster assembly ATPase SufC | - |
| GFB63_RS05590 (GFB63_05735) | sufD | 1080483..1081745 (+) | 1263 | WP_011680669.1 | Fe-S cluster assembly protein SufD | - |
| GFB63_RS05595 (GFB63_05740) | - | 1081799..1083031 (+) | 1233 | WP_046206385.1 | cysteine desulfurase | - |
| GFB63_RS05600 (GFB63_05745) | sufU | 1083018..1083452 (+) | 435 | WP_111679194.1 | Fe-S cluster assembly sulfur transfer protein SufU | - |
| GFB63_RS05605 (GFB63_05750) | sufB | 1083532..1084950 (+) | 1419 | WP_002947647.1 | Fe-S cluster assembly protein SufB | - |
| GFB63_RS05610 (GFB63_05755) | - | 1085234..1086307 (+) | 1074 | Protein_1066 | peptide ABC transporter substrate-binding protein | - |
| GFB63_RS05615 (GFB63_05760) | - | 1086315..1086533 (+) | 219 | Protein_1067 | ABC transporter permease subunit | - |
Sequence
Protein
Download Length: 249 a.a. Molecular weight: 29174.68 Da Isoelectric Point: 4.0481
>NTDB_id=395475 GFB63_RS05575 WP_011680667.1 1077605..1078354(+) (mecA) [Streptococcus thermophilus strain TK-P3A]
MEMKQISETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL
KEDLDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTEPAKEVAEETIREDYTHYVLAF
SDFDQVVTFAQGLKNVSVEGSEFYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL
PVLQATKWS
MEMKQISETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL
KEDLDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTEPAKEVAEETIREDYTHYVLAF
SDFDQVVTFAQGLKNVSVEGSEFYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL
PVLQATKWS
Nucleotide
Download Length: 750 bp
>NTDB_id=395475 GFB63_RS05575 WP_011680667.1 1077605..1078354(+) (mecA) [Streptococcus thermophilus strain TK-P3A]
ATGGAAATGAAACAAATAAGCGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT
GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAACT
TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAATCAGATCTT
AAGGAAGACCTTGATTTCAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT
TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCATGATAAGACCTTGAAAGAGGTTG
ATGAGACTATGACAGAGCCGGCTAAGGAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC
TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAGGGTTCTGAATTTTATAAACTTGG
TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC
TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA
CCGGTATTACAAGCAACGAAATGGAGCTAG
ATGGAAATGAAACAAATAAGCGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT
GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAACT
TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAATCAGATCTT
AAGGAAGACCTTGATTTCAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT
TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCATGATAAGACCTTGAAAGAGGTTG
ATGAGACTATGACAGAGCCGGCTAAGGAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC
TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAGGGTTCTGAATTTTATAAACTTGG
TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC
TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA
CCGGTATTACAAGCAACGAAATGGAGCTAG
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| mecA | Streptococcus thermophilus LMD-9 |
100 |
100 |
1 |
| mecA | Streptococcus thermophilus LMG 18311 |
99.197 |
100 |
0.992 |
| mecA | Streptococcus mutans UA159 |
57.787 |
97.992 |
0.566 |
| mecA | Streptococcus pneumoniae Rx1 |
46.586 |
100 |
0.466 |
| mecA | Streptococcus pneumoniae D39 |
46.586 |
100 |
0.466 |
| mecA | Streptococcus pneumoniae R6 |
46.586 |
100 |
0.466 |
| mecA | Streptococcus pneumoniae TIGR4 |
46.586 |
100 |
0.466 |