Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   GFB63_RS04280 Genome accession   NZ_CP045596
Coordinates   835120..836355 (+) Length   411 a.a.
NCBI ID   WP_084829196.1    Uniprot ID   A0A0E2Q0F1
Organism   Streptococcus thermophilus strain TK-P3A     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 830120..841355
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GFB63_RS04250 (GFB63_04370) - 830585..833191 (+) 2607 WP_193838401.1 YfhO family protein -
  GFB63_RS04270 (GFB63_04390) - 833737..834420 (-) 684 WP_084829194.1 YoaK family protein -
  GFB63_RS04275 (GFB63_04395) rlmH 834436..834915 (-) 480 WP_084829195.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  GFB63_RS04280 (GFB63_04400) htrA 835120..836355 (+) 1236 WP_084829196.1 S1C family serine protease Regulator
  GFB63_RS04285 (GFB63_04405) spo0J 836421..837188 (+) 768 WP_011681768.1 ParB/RepB/Spo0J family partition protein Regulator
  GFB63_RS04290 (GFB63_04410) dnaA 837427..838791 (+) 1365 WP_084828394.1 chromosomal replication initiator protein DnaA -
  GFB63_RS04295 (GFB63_04415) dnaN 838937..840073 (+) 1137 WP_084828395.1 DNA polymerase III subunit beta -
  GFB63_RS04300 (GFB63_04420) - 840124..840315 (+) 192 WP_084828396.1 DUF951 domain-containing protein -

Sequence

Protein


Download         Length: 411 a.a.        Molecular weight: 42859.14 Da        Isoelectric Point: 4.7061

>NTDB_id=395465 GFB63_RS04280 WP_084829196.1 835120..836355(+) (htrA) [Streptococcus thermophilus strain TK-P3A]
MKKFNWKKIVAPIAMLVIGLLGGLLGAFILLTAAGVSFTNTTDTGVKTAKTVYTNITDTTKAVKKVQNAVVSVINYQEGS
SSDSLNDLYGRIFGGGDSSDSSQENSKDSDGLQVAGEGSGVIYKKDGKEAYIVTNNHVVDGAKKLEIMLSDGSKITGELV
GKDTYSDLAVVKVSSDKITTVAEFADSNSLTVGEKAIAIGSPLGTEYANSVTEGIVSSLSRTITMQNDNGETVSTNAIQT
DAAINPGNSGGALVNIEGQVIGINSSKISSTSAIAGSAVEGMGFAIPSNDVVEIINQLEKDGKVTRPALGISIADLNSLS
SSATSKLDLPDEVKSGVVVGSVQKGMPADGKLQEYDVITEIDGKKISSKTDIQTNLYSHSIGDTIKVTFYRGKDKKTVDL
KLTKSTEDISD

Nucleotide


Download         Length: 1236 bp        

>NTDB_id=395465 GFB63_RS04280 WP_084829196.1 835120..836355(+) (htrA) [Streptococcus thermophilus strain TK-P3A]
ATGAAAAAATTTAACTGGAAAAAAATAGTCGCGCCAATTGCAATGCTAGTTATTGGCTTACTAGGTGGTTTACTTGGTGC
CTTTATCCTACTAACAGCAGCCGGGGTATCTTTTACCAATACAACAGATACTGGAGTAAAAACGGCTAAGACCGTCTACA
CCAATATAACAGATACAACTAAGGCTGTTAAGAAAGTACAAAATGCCGTTGTTTCTGTCATCAATTATCAAGAAGGTTCA
TCTTCAGATTCTCTAAATGACCTTTATGGCCGTATCTTTGGCGGAGGGGACAGTTCTGATTCTAGCCAAGAAAATTCAAA
AGATTCAGATGGTCTGCAGGTCGCTGGTGAAGGTTCTGGAGTCATCTATAAAAAAGATGGCAAAGAAGCCTACATCGTAA
CCAATAACCACGTTGTCGATGGGGCTAAAAAACTTGAAATCATGCTTTCGGATGGTTCGAAAATTACTGGTGAACTTGTT
GGTAAAGACACTTACTCTGACCTAGCAGTTGTCAAAGTATCTTCAGATAAAATAACAACTGTTGCAGAATTTGCAGACTC
AAACTCCCTTACTGTTGGTGAAAAAGCAATTGCTATCGGTAGCCCACTTGGTACCGAATACGCCAACTCAGTAACAGAAG
GAATCGTTTCTAGCCTTAGCCGTACTATAACGATGCAAAACGATAATGGTGAAACTGTATCAACAAACGCTATCCAAACA
GATGCAGCCATTAACCCTGGTAACTCTGGTGGTGCCCTAGTCAATATTGAAGGACAAGTTATCGGTATTAACTCAAGTAA
AATTTCATCAACGTCTGCAATCGCTGGTAGTGCTGTTGAAGGTATGGGGTTTGCCATTCCATCAAACGATGTTGTTGAAA
TCATCAATCAATTAGAAAAAGATGGTAAAGTTACACGACCAGCACTAGGGATCTCAATAGCAGATCTTAATAGCCTTTCT
AGCAGCGCAACTTCTAAATTAGATTTACCAGATGAGGTCAAATCCGGTGTTGTTGTCGGTAGTGTTCAGAAAGGTATGCC
AGCTGACGGTAAACTTCAAGAATATGATGTTATCACTGAGATTGATGGTAAGAAGATTAGCTCAAAAACTGATATTCAAA
CCAATCTTTACAGCCATAGTATCGGAGATACTATCAAGGTAACCTTCTATCGTGGTAAAGATAAGAAAACTGTAGATCTT
AAATTAACAAAATCTACAGAAGACATATCTGATTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(307-402)

Trypsin-like peptidase domain (Trypsin_2)

(118-263)

Peptidase family M50 (Peptidase_M50)

(4-406)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0E2Q0F1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

62.035

98.054

0.608
  htrA Streptococcus gordonii str. Challis substr. CH1

57.282

100

0.574
  htrA Streptococcus mitis NCTC 12261

54.034

99.513

0.538
  htrA Streptococcus pneumoniae TIGR4

53.79

99.513

0.535
  htrA Streptococcus pneumoniae D39

53.79

99.513

0.535
  htrA Streptococcus pneumoniae Rx1

53.79

99.513

0.535
  htrA Streptococcus pneumoniae R6

53.79

99.513

0.535

Multiple sequence alignment