Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   FSA28_RS05600 Genome accession   NZ_CP044495
Coordinates   1134320..1134994 (-) Length   224 a.a.
NCBI ID   WP_088741834.1    Uniprot ID   -
Organism   Streptococcus mutans strain UA140     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1129320..1139994
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FSA28_RS05575 (FSA28_0882) - 1129628..1130905 (-) 1278 WP_002291163.1 pyrimidine-nucleoside phosphorylase -
  FSA28_RS05580 (FSA28_0883) - 1131014..1131610 (-) 597 WP_002283580.1 class I SAM-dependent methyltransferase -
  FSA28_RS05585 (FSA28_0884) coaA 1131706..1132626 (+) 921 WP_002262217.1 type I pantothenate kinase -
  FSA28_RS05590 (FSA28_0885) rpsT 1132680..1132934 (+) 255 WP_011074586.1 30S ribosomal protein S20 -
  FSA28_RS05595 (FSA28_0886) ciaH 1133023..1134330 (-) 1308 WP_002264510.1 three-component system sensor histidine kinase CiaH Regulator
  FSA28_RS05600 (FSA28_0887) ciaR 1134320..1134994 (-) 675 WP_088741834.1 three-component system response regulator CiaR Regulator
  FSA28_RS05605 (FSA28_0888) ciaX 1135045..1135308 (-) 264 WP_002291165.1 three-component system regulator CiaX -
  FSA28_RS05610 (FSA28_0890) - 1135710..1138259 (-) 2550 WP_002291167.1 M1 family metallopeptidase -
  FSA28_RS05615 (FSA28_0891) phoU 1138300..1138953 (-) 654 WP_002262211.1 phosphate signaling complex protein PhoU -
  FSA28_RS05620 (FSA28_0892) pstB 1138985..1139743 (-) 759 WP_002262210.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25516.33 Da        Isoelectric Point: 4.4356

>NTDB_id=390439 FSA28_RS05600 WP_088741834.1 1134320..1134994(-) (ciaR) [Streptococcus mutans strain UA140]
MIKLLLVEDDLSLSNSIFDFLDDFADVMQVFDGAEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENNLTYGELTVDTATNTTMVNRKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKDTTFGKNLQTLRSVGYILKDAN

Nucleotide


Download         Length: 675 bp        

>NTDB_id=390439 FSA28_RS05600 WP_088741834.1 1134320..1134994(-) (ciaR) [Streptococcus mutans strain UA140]
ATGATAAAGTTATTATTAGTAGAAGACGATTTGAGTCTATCTAACTCTATCTTTGACTTTCTGGATGATTTTGCTGATGT
CATGCAGGTTTTTGATGGTGCAGAAGGACTGTATGAAGCAGAGAGTGGCGTTTATGATTTGATTCTATTAGACTTAATGC
TTCCTGAAAAAAATGGCTTCCAAGTTTTAAAAGAACTGCGTGAAAAAGGGATAACGACACCTGTTTTAATTATGACAGCT
AAGGAAGGTTTGGATGACAAAGGACACGGTTTTGAATTAGGAGCTGATGATTATCTGACAAAACCATTTTATCTTGAAGA
ATTAAAAATGCGTATTCAGGCCCTCCTCAAACGTTCAGGCAAATTCAACGAAAATAATCTGACTTACGGTGAGTTAACCG
TTGATACAGCAACTAATACAACAATGGTAAATAGAAAAGAAGTTGAACTGCTTGGCAAAGAGTTTGACTTATTAGTTTAT
TTCTTACAAAATCAAAATGTCATTTTACCTAAGTCACAAATTTTTGATCGTATCTGGGGCTTTGATAGCGATACGACAAT
TTCGGTTGTTGAAGTCTATGTTTCTAAAATAAGAAAGAAATTAAAAGACACCACATTTGGAAAGAATTTACAGACATTAC
GCAGTGTAGGATATATTTTGAAGGATGCTAATTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

99.107

100

0.991
  ciaR Streptococcus pneumoniae Rx1

87.946

100

0.879
  ciaR Streptococcus pneumoniae D39

87.946

100

0.879
  ciaR Streptococcus pneumoniae TIGR4

87.946

100

0.879
  ciaR Streptococcus pneumoniae R6

87.946

100

0.879
  vicR Streptococcus mutans UA159

35.193

100

0.366
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36

100

0.362

Multiple sequence alignment