Detailed information NTG0390271

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: FSA31_RS00355
• Genome accession: NZ_CP044492
• Coordinates: 57826..58740 (+)
• Length: 304 a.a.
• NCBI ID: WP_002275820.1
• Uniprot ID: A0AAX1K1I3
• Organism: Streptococcus mutans strain T8
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 52826..63740

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FSA31_RS00330 (FSA31_0065)	-	52854..53543 (+)	690	WP_002284803.1	aspartate/glutamate racemase family protein	-
FSA31_RS00335 (FSA31_0066)	-	53554..53979 (+)	426	WP_002284804.1	SRPBCC family protein	-
FSA31_RS00340 (FSA31_0067)	-	54010..55050 (+)	1041	WP_002284805.1	hypothetical protein	-
FSA31_RS09930 (FSA31_0068)	-	55043..55183 (+)	141	WP_002266374.1	hypothetical protein	-
FSA31_RS00345 (FSA31_0069)	purB	55438..56736 (+)	1299	WP_002284806.1	adenylosuccinate lyase	-
FSA31_RS00350 (FSA31_0070)	-	56756..57442 (+)	687	WP_002264678.1	DNA alkylation repair protein	-
FSA31_RS00355 (FSA31_0071)	comR	57826..58740 (+)	915	WP_002275820.1	helix-turn-helix domain-containing protein	Regulator
FSA31_RS00360 (FSA31_0072)	-	59272..61113 (-)	1842	WP_002284807.1	carbohydrate-binding domain-containing protein	-
FSA31_RS00365 (FSA31_0073)	ruvB	61449..62444 (+)	996	WP_002284808.1	Holliday junction branch migration DNA helicase RuvB	-
FSA31_RS00370 (FSA31_0074)	-	62482..62907 (+)	426	WP_002278431.1	low molecular weight protein-tyrosine-phosphatase	-
FSA31_RS00375 (FSA31_0075)	-	62972..63355 (+)	384	WP_011074470.1	membrane protein	-

Sequence

Protein

• Length: 304 a.a.
• Molecular weight: 35228.36 Da
• Isoelectric Point: 5.0064

>NTDB_id=390271 FSA31_RS00355 WP_002275820.1 57826..58740(+) (comR) [Streptococcus mutans strain T8]
MLKDFGKKIKSLRLEKGLTKEAVCLDESQLSTRQLTRIESGQSTPTLNKAVYIAGRLGVTLGYLTDGENVELPSRYKELK
YLLLRTPTYGDQQRLAEKETYFDEIFSQFYDDLPEEEQLIIDGLQSKLDIHFSDNIDFGVGILNDYFDQILRKTNYQVND
LILIDLYFSCLTVSGLDSAIFDSRKYNQLLETLLKQVDCLPLEDLFVLNNVLLNNFGLLLELKKYDFVKQLIAVSNKIMA
RTYDFQKKPIVNLLTWKHHLFVEKDYAKAKKSYDAAILFAQLTENINLRENLEKEWQKDSQNGT

Nucleotide

• Length: 915 bp

>NTDB_id=390271 FSA31_RS00355 WP_002275820.1 57826..58740(+) (comR) [Streptococcus mutans strain T8]
ATGTTAAAAGATTTTGGGAAGAAAATTAAGAGCCTGAGGTTAGAAAAGGGGCTGACCAAAGAGGCTGTCTGCCTTGATGA
ATCTCAATTGTCAACACGGCAGCTGACTAGAATTGAATCGGGACAGTCTACGCCAACTCTTAATAAAGCTGTTTATATTG
CAGGACGTTTAGGAGTGACGCTTGGCTATTTAACGGACGGAGAAAATGTTGAGTTACCCAGTCGTTATAAAGAACTAAAG
TATTTATTATTACGAACGCCAACCTATGGCGACCAGCAAAGATTAGCTGAAAAAGAAACCTATTTTGACGAGATTTTTAG
TCAGTTTTATGATGATTTGCCTGAAGAAGAACAATTGATTATTGATGGTTTACAATCGAAACTAGATATTCATTTTAGTG
ACAATATCGATTTTGGCGTTGGTATTTTAAATGACTATTTTGATCAGATTTTAAGAAAAACCAATTATCAGGTCAATGAT
TTGATTCTGATTGATCTCTATTTTTCCTGCTTAACTGTTAGTGGTTTGGATTCAGCTATTTTTGATTCAAGAAAATATAA
TCAATTATTGGAGACATTGCTTAAGCAGGTAGACTGCCTTCCATTGGAAGATCTTTTCGTTTTAAATAATGTTTTATTGA
ATAATTTTGGACTCCTCTTAGAATTGAAAAAATATGATTTTGTTAAGCAGCTTATTGCTGTCAGCAATAAAATCATGGCT
AGAACTTATGATTTTCAAAAAAAGCCTATTGTTAATCTTCTGACATGGAAGCATCATTTATTTGTTGAAAAAGATTATGC
GAAAGCTAAAAAGAGCTATGATGCTGCTATCTTATTTGCCCAGTTAACAGAAAACATTAATTTAAGAGAAAATTTGGAGA
AAGAATGGCAAAAAGATTCTCAGAACGGGACATAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (9-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus mutans UA159	99.013	100	0.99
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	52.431	94.737	0.497
comR	Streptococcus pyogenes MGAS8232	47.02	99.342	0.467
comR	Streptococcus pyogenes MGAS315	47.157	98.355	0.464
comR	Streptococcus suis 05ZYH33	43.478	98.355	0.428
comR	Streptococcus suis P1/7	43.478	98.355	0.428
comR	Streptococcus suis D9	37	98.684	0.365