Detailed information NTG0388843

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: F5989_RS06475
• Genome accession: NZ_CP044221
• Coordinates: 1305791..1306999 (-)
• Length: 402 a.a.
• NCBI ID: WP_002262650.1
• Uniprot ID: Q8DRQ6
• Organism: Streptococcus mutans strain NCH105
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1300791..1311999

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
F5989_RS06455 (F5989_06575)	-	1301236..1301427 (-)	192	WP_002264634.1	DUF951 domain-containing protein	-
F5989_RS06460 (F5989_06580)	dnaN	1301689..1302825 (-)	1137	WP_002267293.1	DNA polymerase III subunit beta	-
F5989_RS06465 (F5989_06585)	dnaA	1302981..1304339 (-)	1359	WP_002262648.1	chromosomal replication initiator protein DnaA	-
F5989_RS06470 (F5989_06590)	spo0J	1304541..1305311 (-)	771	WP_002267292.1	ParB/RepB/Spo0J family partition protein	Regulator
F5989_RS06475 (F5989_06595)	htrA	1305791..1306999 (-)	1209	WP_002262650.1	S1C family serine protease	Regulator
F5989_RS06480 (F5989_06600)	rlmH	1307205..1307684 (+)	480	WP_002267291.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
F5989_RS06485 (F5989_06605)	-	1308028..1308690 (+)	663	WP_002262652.1	YoaK family protein	-

Sequence

Protein

• Length: 402 a.a.
• Molecular weight: 43071.55 Da
• Isoelectric Point: 8.8092

>NTDB_id=388843 F5989_RS06475 WP_002262650.1 1305791..1306999(-) (htrA) [Streptococcus mutans strain NCH105]
MNNTKSHPFLKWFIPFLVIFLTFILGVISTLTFNWITGNKSFSNNGKTTVSNVIYDTKSNTTKAVKNVKNTVVSVINYQK
TDNSYYNYDSGSQEKNKSEDGLGVYGEGSGVIYKKDGDSAYLVTNNHVVKDAEKLEIMMANGKKVVGKLVGSDTYSDLAV
IKISSKYVTTVAEFANSDKIKVGEPAIAIGSPLGSDYANSVTEGIVSSLSRTVTSQNENGETISTNAIQTDAAINPGNSG
GALINIKGQVIGINSSKIASSNNSNSGVAVEGMGFAIPSNDVVSIINQLEENGEVVRPALGISMANLSEASTSGRDTLKI
PSDVTSGIVVLSTQSGMPADGKLKKYDVITEIDGKKVASISDLQSILYKHKKGDKIKLTFYREKDKQTVEIQLTKTSQDL
NH

Nucleotide

• Length: 1209 bp

>NTDB_id=388843 F5989_RS06475 WP_002262650.1 1305791..1306999(-) (htrA) [Streptococcus mutans strain NCH105]
GTGAATAATACGAAATCTCACCCTTTTTTAAAATGGTTTATACCTTTTTTAGTTATTTTTTTAACTTTTATTTTAGGGGT
CATATCAACACTTACCTTTAATTGGATAACTGGTAACAAATCGTTTTCTAACAATGGAAAAACAACTGTTAGTAATGTCA
TTTATGATACCAAATCTAACACTACCAAGGCTGTTAAAAATGTCAAAAATACAGTTGTATCTGTCATCAATTATCAAAAA
ACAGATAATAGTTATTACAATTATGACAGCGGTTCTCAAGAAAAAAATAAATCAGAGGATGGTCTAGGAGTCTACGGTGA
AGGTTCTGGTGTTATCTACAAAAAAGATGGCGATAGTGCTTATTTAGTCACAAACAATCATGTCGTTAAAGATGCAGAAA
AGTTAGAAATCATGATGGCTAATGGTAAAAAAGTTGTCGGTAAATTAGTAGGTTCTGATACTTATTCTGATCTGGCTGTT
ATTAAAATTTCTTCTAAGTATGTTACGACAGTTGCTGAATTTGCTAATTCGGATAAAATAAAAGTTGGAGAACCAGCAAT
CGCTATTGGTAGCCCTTTAGGCAGTGATTATGCTAATTCTGTAACAGAAGGAATTGTTTCAAGTCTCAGTCGTACAGTAA
CTTCACAAAATGAAAATGGCGAAACAATTTCAACTAATGCTATTCAAACAGACGCAGCTATTAACCCTGGTAATTCTGGT
GGCGCTTTAATTAATATCAAAGGACAAGTTATTGGTATCAATTCAAGTAAAATTGCATCAAGTAATAACTCAAATAGTGG
CGTTGCTGTTGAAGGAATGGGCTTTGCAATTCCTTCAAACGATGTTGTCTCTATTATTAATCAATTAGAAGAAAATGGTG
AAGTTGTTAGACCCGCTCTTGGTATTTCAATGGCTAATCTTAGTGAAGCTTCAACAAGTGGAAGAGATACTTTAAAAATA
CCAAGTGATGTCACAAGCGGTATTGTTGTTCTTTCAACACAAAGTGGTATGCCAGCAGATGGGAAGCTAAAGAAATATGA
TGTCATTACAGAAATTGATGGGAAGAAGGTAGCGTCTATCAGCGATCTTCAAAGTATTCTTTACAAACACAAAAAGGGAG
ATAAAATTAAACTCACTTTCTATCGCGAAAAAGATAAACAAACAGTTGAGATCCAATTAACTAAAACAAGTCAAGATTTG
AATCATTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (298-393)

• Trypsin-like peptidase domain (Trypsin_2) (108-253)

• Peptidase family M50 (Peptidase_M50) (227-398)

3D structure

• AlphaFold DB: Q8DRQ6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	100	100	1
htrA	Streptococcus gordonii str. Challis substr. CH1	56.14	99.254	0.557
htrA	Streptococcus mitis NCTC 12261	54.684	98.259	0.537
htrA	Streptococcus pneumoniae Rx1	54.315	98.01	0.532
htrA	Streptococcus pneumoniae D39	54.315	98.01	0.532
htrA	Streptococcus pneumoniae R6	54.315	98.01	0.532
htrA	Streptococcus pneumoniae TIGR4	54.315	98.01	0.532