Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   F5989_RS06115 Genome accession   NZ_CP044221
Coordinates   1244656..1245570 (-) Length   304 a.a.
NCBI ID   WP_002263400.1    Uniprot ID   Q8DWI6
Organism   Streptococcus mutans strain NCH105     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1239656..1250570
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  F5989_RS06095 (F5989_06215) - 1240036..1240419 (-) 384 WP_011074470.1 membrane protein -
  F5989_RS06100 (F5989_06220) - 1240484..1240909 (-) 426 WP_002271312.1 low molecular weight protein-tyrosine-phosphatase -
  F5989_RS06105 (F5989_06225) ruvB 1240947..1241942 (-) 996 WP_002271311.1 Holliday junction branch migration DNA helicase RuvB -
  F5989_RS06110 (F5989_06230) - 1242278..1244122 (+) 1845 WP_002267914.1 carbohydrate-binding domain-containing protein -
  F5989_RS06115 (F5989_06235) comR 1244656..1245570 (-) 915 WP_002263400.1 helix-turn-helix domain-containing protein Regulator
  F5989_RS06120 (F5989_06240) - 1245952..1246641 (-) 690 WP_002271308.1 DNA alkylation repair protein -
  F5989_RS06125 (F5989_06245) purB 1246661..1247959 (-) 1299 WP_002269365.1 adenylosuccinate lyase -
  F5989_RS06130 (F5989_06250) - 1247976..1248851 (-) 876 WP_002269364.1 hypothetical protein -
  F5989_RS06135 (F5989_06255) - 1248879..1249295 (-) 417 WP_002269363.1 SRPBCC family protein -
  F5989_RS06140 (F5989_06260) - 1249289..1249570 (-) 282 WP_002266371.1 hypothetical protein -
  F5989_RS06145 (F5989_06265) - 1249664..1250356 (-) 693 WP_002264672.1 aspartate/glutamate racemase family protein -

Sequence

Protein


Download         Length: 304 a.a.        Molecular weight: 35247.28 Da        Isoelectric Point: 4.8341

>NTDB_id=388840 F5989_RS06115 WP_002263400.1 1244656..1245570(-) (comR) [Streptococcus mutans strain NCH105]
MLKDFGKKIKSLRLEKGLTKEAVCLDESQLSTRQLTRIESGQSTPTLNKAVYIAGRLGVTLGYLTDGENVELPSRYKELK
YLLLRTPTYGDQQRLAEKETYFDEIFSQFYDDLPEEEQLIIDGLQSKLDIHFSDNIDFGVGILNDYFDQILRKTNYQVND
LILIDLYFSCLTVSGLDSAIFDSRKYNQLLETLLKQVDCLPLEDLFVLNNVLLNNFGLLLELKKYDFVKQLIAVSNKIMD
RTHDFQKKPIVNLLTWKHHLFVEKDYAEAKKSYDAAILFAQLTENINLRENLEKEWQKDSQNGT

Nucleotide


Download         Length: 915 bp        

>NTDB_id=388840 F5989_RS06115 WP_002263400.1 1244656..1245570(-) (comR) [Streptococcus mutans strain NCH105]
ATGTTAAAAGATTTTGGGAAGAAAATTAAGAGCCTGAGGTTAGAAAAGGGGCTGACCAAAGAAGCTGTCTGCCTTGATGA
ATCTCAATTGTCAACACGGCAGTTGACCAGAATTGAATCAGGACAGTCTACGCCAACTCTTAATAAAGCTGTTTATATTG
CAGGACGTTTAGGAGTGACGCTTGGCTATTTAACGGACGGAGAAAATGTTGAGTTACCCAGTCGTTATAAAGAACTAAAG
TATTTATTATTACGAACGCCAACCTATGGCGACCAACAAAGATTAGCTGAAAAAGAAACCTATTTTGACGAGATTTTTAG
TCAGTTTTATGATGATTTGCCTGAAGAAGAACAATTGATTATTGATGGCTTACAATCGAAACTAGATATTCATTTTAGTG
ACAATATCGATTTTGGCGTTGGTATTTTAAATGACTATTTTGATCAGATTTTAAGAAAAACCAATTATCAGGTCAATGAT
TTGATTCTGATTGATCTCTATTTTTCCTGCTTAACTGTTAGTGGTTTGGATTCAGCTATTTTTGATTCAAGAAAATATAA
TCAATTATTGGAGACATTGCTTAAGCAGGTAGACTGCCTTCCATTGGAAGATCTTTTCGTTTTAAATAATGTTTTATTGA
ATAATTTTGGACTCCTCTTAGAATTGAAAAAATATGATTTTGTTAAGCAGCTTATTGCTGTCAGCAATAAAATCATGGAT
AGAACTCATGATTTTCAAAAAAAGCCTATTGTTAATCTTCTGACATGGAAGCATCATTTATTTGTTGAAAAAGATTATGC
GGAAGCTAAAAAGAGCTATGATGCTGCTATCTTATTTGCCCAGTTAACAGAAAACATTAATTTAAGAGAAAATTTGGAGA
AAGAATGGCAAAAAGATTCTCAGAACGGGACATAA

Domains

Predicted by InterproScan.

Helix-turn-helix (HTH_3)

(9-64)

ComR tetratricopeptide (ComR_TPR)

(73-296)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 7N10
  PDB 7N1N

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus mutans UA159

100

100

1
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

52.778

94.737

0.5
  comR Streptococcus pyogenes MGAS315

47.157

98.355

0.464
  comR Streptococcus pyogenes MGAS8232

46.358

99.342

0.461
  comR Streptococcus suis P1/7

43.813

98.355

0.431
  comR Streptococcus suis 05ZYH33

43.813

98.355

0.431
  comR Streptococcus suis D9

37

98.684

0.365

Multiple sequence alignment