Detailed information NTG0038344

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: SP670_RS12105
• Genome accession: NC_014498
• Coordinates: 2238032..2239213 (+)
• Length: 393 a.a.
• NCBI ID: WP_000681601.1
• Uniprot ID: A0A0B7LRW6
• Organism: Streptococcus pneumoniae 670-6B
• Function: degrading CSP; selective degradation of ComEA and ComEC (predicted from homology) Competence regulation

Genomic Context

Location: 2233032..2244213

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SP670_RS12065 (SP670_2378)	-	2234084..2234626 (+)	543	WP_001158267.1	TetR/AcrR family transcriptional regulator	-
SP670_RS12080 (SP670_2379)	comE	2234868..2235620 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
SP670_RS12085 (SP670_2380)	comD/comD1	2235617..2236942 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
SP670_RS12090 (SP670_2381)	comC/comC1	2236963..2237088 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
SP670_RS12100 (SP670_2382)	rlmH	2237370..2237849 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SP670_RS12105 (SP670_2383)	htrA	2238032..2239213 (+)	1182	WP_000681601.1	S1C family serine protease	Regulator
SP670_RS12110 (SP670_2384)	spo0J	2239271..2240029 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41855.70 Da
• Isoelectric Point: 6.8902

>NTDB_id=38344 SP670_RS12105 WP_000681601.1 2238032..2239213(+) (htrA) [Streptococcus pneumoniae 670-6B]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLRSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=38344 SP670_RS12105 WP_000681601.1 2238032..2239213(+) (htrA) [Streptococcus pneumoniae 670-6B]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAGATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTGA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

• PDZ domain (PDZ_2) (289-384)

3D structure

• AlphaFold DB: A0A0B7LRW6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus pneumoniae Rx1	99.491	100	0.995
htrA	Streptococcus pneumoniae D39	99.491	100	0.995
htrA	Streptococcus pneumoniae R6	99.491	100	0.995
htrA	Streptococcus pneumoniae TIGR4	99.491	100	0.995
htrA	Streptococcus mitis NCTC 12261	97.201	100	0.972
htrA	Streptococcus gordonii str. Challis substr. CH1	66.919	100	0.674
htrA	Streptococcus mutans UA159	54.822	100	0.55