Detailed information NTG0375002

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: FPL13_RS03295
• Genome accession: NZ_CP041968
• Coordinates: 669209..669883 (+)
• Length: 224 a.a.
• NCBI ID: WP_003024352.1
• Uniprot ID: A0AAI9NIE3
• Organism: Streptococcus sp. KS 6
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 664209..674883

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FPL13_RS03275 (FPL13_03320)	-	666510..667469 (+)	960	WP_003027901.1	ROK family glucokinase	-
FPL13_RS03280 (FPL13_03325)	rplS	667620..667967 (+)	348	WP_049512881.1	50S ribosomal protein L19	-
FPL13_RS03290 (FPL13_03335)	-	668482..668937 (+)	456	WP_003029592.1	hypothetical protein	-
FPL13_RS03295 (FPL13_03340)	ciaR	669209..669883 (+)	675	WP_003024352.1	response regulator transcription factor	Regulator
FPL13_RS03300 (FPL13_03345)	ciaH	669873..671219 (+)	1347	WP_049512879.1	sensor histidine kinase	Regulator
FPL13_RS03305 (FPL13_03350)	-	671608..673056 (-)	1449	WP_049512877.1	alpha-amylase	-
FPL13_RS03310 (FPL13_03355)	-	673233..674846 (+)	1614	WP_049512875.1	M20/M25/M40 family metallo-hydrolase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25359.01 Da
• Isoelectric Point: 4.2408

>NTDB_id=375002 FPL13_RS03295 WP_003024352.1 669209..669883(+) (ciaR) [Streptococcus sp. KS 6]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLIMTA
KESLNDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTVNLSTNTTLVDGNEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNLQTLRSVGYILKDAE

Nucleotide

• Length: 675 bp

>NTDB_id=375002 FPL13_RS03295 WP_003024352.1 669209..669883(+) (ciaR) [Streptococcus sp. KS 6]
ATGATTAAGATTCTATTAGTGGAAGACGATCTCGGTCTATCTAATTCAGTATTTGACTTTTTGGATGATTTTGCAGATGT
TATGCAAGTTTTTGATGGTGAGGAAGGATTGTATGAGGCTGAGAGTGGCGTGTACGACCTTATCTTGCTTGACTTGATGC
TGCCAGAAAAAGACGGCTTCCAAGTGTTGAAAGAATTGCGTGAAAAAGGTGTCACAACTCCTGTGCTAATCATGACAGCC
AAAGAAAGTTTGAATGATAAAGGACATGGTTTTGAACTGGGTGCTGATGATTATTTGACCAAACCATTTTATTTGGAAGA
ATTAAAAATGCGGATTCAAGCTCTGTTGAAGCGTTCTGGCAAGTTTAATGAAAACACCCTTTCTTATGGCGATGTCACTG
TTAATTTATCAACTAACACAACACTTGTAGATGGAAACGAAGTAGAATTGCTCGGAAAAGAATTTGACTTGCTGGTGTAT
TTCTTGCAAAATCAAAATGTCATTTTGCCTAAGACACAGATTTTCGATCGCTTGTGGGGATTTGATAGTGATACAACGAT
TTCAGTCGTAGAAGTCTATGTTTCAAAAATCCGGAAAAAATTGAAAGGGACGACCTTTGCGAACAATCTTCAAACGCTTC
GCAGCGTCGGATATATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	91.964	100	0.92
ciaR	Streptococcus pneumoniae D39	91.964	100	0.92
ciaR	Streptococcus pneumoniae R6	91.964	100	0.92
ciaR	Streptococcus pneumoniae TIGR4	91.964	100	0.92
ciaR	Streptococcus mutans UA159	90.135	99.554	0.897
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.767	100	0.393
vicR	Streptococcus mutans UA159	36.052	100	0.375
covR	Streptococcus salivarius strain HSISS4	35.683	100	0.362