Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   FDP16_RS06900 Genome accession   NZ_CP040798
Coordinates   1359019..1359693 (-) Length   224 a.a.
NCBI ID   WP_176799091.1    Uniprot ID   A0A7H8V1M3
Organism   Streptococcus sanguinis strain CGMH058     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1354019..1364693
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FDP16_RS06880 (FDP16_07165) - 1354409..1355806 (-) 1398 WP_176799088.1 polysaccharide deacetylase family protein -
  FDP16_RS06885 (FDP16_07170) - 1355868..1356254 (-) 387 WP_002895748.1 VOC family protein -
  FDP16_RS06895 (FDP16_07180) ciaH 1357638..1359029 (-) 1392 WP_176799090.1 cell wall metabolism sensor histidine kinase WalK Regulator
  FDP16_RS06900 (FDP16_07185) ciaR 1359019..1359693 (-) 675 WP_176799091.1 response regulator transcription factor Regulator
  FDP16_RS06905 (FDP16_07190) - 1359799..1360281 (-) 483 WP_176799092.1 hypothetical protein -
  FDP16_RS06910 (FDP16_07195) - 1360590..1363131 (-) 2542 Protein_1346 M1 family metallopeptidase -
  FDP16_RS06915 (FDP16_07200) - 1363297..1363623 (-) 327 WP_176799093.1 hypothetical protein -
  FDP16_RS06920 (FDP16_07205) - 1363632..1363928 (-) 297 WP_176799094.1 hypothetical protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25282.01 Da        Isoelectric Point: 4.4430

>NTDB_id=367225 FDP16_RS06900 WP_176799091.1 1359019..1359693(-) (ciaR) [Streptococcus sanguinis strain CGMH058]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQMLKELRAKGVTTPVLITTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLSYGDVTVNLSTNSTLKDGKDVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTAFAKNLHTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=367225 FDP16_RS06900 WP_176799091.1 1359019..1359693(-) (ciaR) [Streptococcus sanguinis strain CGMH058]
ATGATTAAAATTCTATTAGTAGAAGATGACCTTGGACTGTCAAACTCAGTTTTTGATTTTTTAGATGATTTTGCAGATGT
GATGCAGGTTTTTGATGGCGAAGAAGGCCTTTATGAAGCAGAGAGCGGTGTTTATGACCTCATCTTGCTGGATCTCATGT
TGCCTGAGAAGGATGGTTTCCAAATGCTTAAGGAACTCCGGGCAAAAGGAGTCACAACCCCTGTTCTGATCACGACAGCT
AAGGAAAGCTTGGATGACAAAGGACATGGCTTTGAGCTCGGCGCTGATGACTATCTGACAAAACCTTTCTATTTGGAAGA
ACTGAAAATGCGGATCCAGGCGCTCTTGAAACGTGCAGGTAAATTCAACGAGAATACTCTTTCTTATGGTGATGTGACGG
TCAATCTATCCACAAATTCAACATTGAAAGACGGTAAAGACGTAGAGTTGCTTGGTAAAGAATTCGATCTCTTGGTTTAT
TTCTTGCAAAATCAAAATGTAATCCTGCCTAAGACTCAAATTTTTGACCGACTGTGGGGCTTTGACAGTGATACCACTGT
TTCCGTTGTTGAAGTGTACGTTTCCAAGATTCGTAAAAAACTGAAAGGAACGGCATTTGCGAAAAACCTACATACTCTTC
GTAGTGTCGGCTACATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7H8V1M3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

88.393

100

0.884
  ciaR Streptococcus pneumoniae D39

88.393

100

0.884
  ciaR Streptococcus pneumoniae R6

88.393

100

0.884
  ciaR Streptococcus pneumoniae TIGR4

88.393

100

0.884
  ciaR Streptococcus mutans UA159

86.996

99.554

0.866
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.326

100

0.388
  vicR Streptococcus mutans UA159

35.622

100

0.371

Multiple sequence alignment