Detailed information NTG0367224

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: FDP16_RS06895
• Genome accession: NZ_CP040798
• Coordinates: 1357638..1359029 (-)
• Length: 463 a.a.
• NCBI ID: WP_176799090.1
• Uniprot ID: A0A7H8V1L6
• Organism: Streptococcus sanguinis strain CGMH058
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	1356361..1357466	1357638..1359029	flank	172

Gene organization within MGE regions

Location: 1356361..1359029

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FDP16_RS06895 (FDP16_07180)	ciaH	1357638..1359029 (-)	1392	WP_176799090.1	cell wall metabolism sensor histidine kinase WalK	Regulator

Sequence

Protein

• Length: 463 a.a.
• Molecular weight: 52511.80 Da
• Isoelectric Point: 8.8401

>NTDB_id=367224 FDP16_RS06895 WP_176799090.1 1357638..1359029(-) (ciaH) [Streptococcus sanguinis strain CGMH058]
MLNKIKKTFYADDFSYFIRYFGLFTLIFSAMTLIIIQVMRSSLYTSVDENLKNLSNNPSSVADLAYRTTGQQSDPSNKVN
TKSPKSSKEPDGDPNEESKSDNLTTPNVSSNTFALLLDDNYKNISTSKSDGFLDFNSLDFNKSYLNQIKEIVIGNSFGQT
ESYRAYLFDIDPNNEYPDIKYAVVMTSISQLEQTSGKHEQLIVMVMVSFWGISLIASIYLARMSVKPLLESIQKQKAFVE
NASHELRTPLAVLQSRLETLFRKPEATIMQSSENIASSLDEVRNMRLLTTNLLNLARRDDGIKPQYGEVEPEFFDTTFAN
YCIIARENKKTFHSENMIKHPIVTDQILLKQLMTILFDNAIKYTDDDGEISVTAASSDRYLIFRVADNGPGISNEDKKKI
FDRFYRVDKARTRQKGGFGLGLSLAKQIVDAFKGTIYAKDNKPKGTVFEVKLLLKETKKRSVK

Nucleotide

• Length: 1392 bp

>NTDB_id=367224 FDP16_RS06895 WP_176799090.1 1357638..1359029(-) (ciaH) [Streptococcus sanguinis strain CGMH058]
ATGCTGAATAAAATCAAGAAGACCTTTTATGCGGATGATTTCTCTTATTTCATTCGCTATTTTGGGTTATTTACATTAAT
CTTCTCAGCCATGACCTTGATTATTATTCAGGTTATGCGTTCCAGCCTTTATACGTCAGTTGATGAAAATCTGAAAAACC
TGAGTAATAATCCTAGTTCGGTAGCAGATTTGGCCTATCGGACGACAGGTCAGCAGTCTGATCCTAGCAATAAGGTCAAC
ACTAAAAGTCCTAAAAGTAGTAAAGAGCCAGATGGCGATCCAAACGAAGAGTCTAAGTCTGACAATCTGACGACGCCAAA
TGTTAGTTCTAACACTTTCGCCCTGCTTTTGGATGATAATTATAAAAATATTTCCACTAGCAAGAGCGATGGCTTTCTGG
ACTTTAACTCGCTGGACTTTAACAAGTCCTATCTGAATCAGATCAAGGAAATTGTAATTGGCAACAGCTTTGGCCAGACA
GAAAGCTATCGGGCTTATCTCTTTGATATTGACCCCAATAATGAATATCCAGATATTAAGTACGCTGTGGTCATGACTAG
CATCAGCCAGCTGGAGCAAACTAGCGGCAAGCATGAGCAGTTGATTGTCATGGTTATGGTCAGCTTTTGGGGTATTTCCC
TGATTGCCAGTATTTATCTGGCTCGGATGAGTGTTAAGCCCTTGCTGGAAAGTATCCAGAAGCAGAAGGCTTTCGTGGAA
AATGCCAGTCATGAACTGCGGACACCTTTGGCTGTTTTGCAGAGCCGCTTAGAAACGCTCTTTCGTAAGCCTGAAGCAAC
AATTATGCAGAGCAGTGAAAATATCGCTTCTAGCTTGGATGAAGTACGCAATATGCGTTTGCTGACGACCAATCTTCTCA
ATCTGGCTCGTCGTGATGATGGTATCAAGCCCCAATATGGTGAAGTCGAACCGGAATTTTTTGATACGACCTTTGCTAAT
TACTGCATTATCGCAAGGGAGAATAAAAAAACTTTTCATTCGGAAAATATGATCAAGCACCCTATTGTGACAGATCAAAT
TTTGCTCAAGCAGCTGATGACCATCCTGTTTGACAATGCTATCAAGTACACAGATGATGACGGCGAAATCAGTGTCACGG
CTGCTTCAAGCGATCGTTATCTCATCTTTCGGGTAGCAGATAATGGACCTGGTATCAGCAACGAAGATAAGAAGAAGATT
TTTGATCGCTTTTATCGGGTTGACAAGGCTCGGACCCGTCAGAAAGGTGGCTTTGGTCTGGGGCTTTCTCTGGCCAAGCA
GATTGTCGATGCTTTCAAGGGCACTATTTATGCCAAGGACAACAAACCAAAAGGTACGGTCTTTGAAGTTAAACTGCTAC
TGAAGGAAACGAAAAAGCGCTCTGTTAAATAG

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (236-301)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (344-454)

3D structure

• AlphaFold DB: A0A7H8V1L6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus pneumoniae Rx1	61.171	99.568	0.609
ciaH	Streptococcus pneumoniae D39	61.171	99.568	0.609
ciaH	Streptococcus pneumoniae R6	61.171	99.568	0.609
ciaH	Streptococcus pneumoniae TIGR4	61.171	99.568	0.609
ciaH	Streptococcus mutans UA159	52.851	98.488	0.521