Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   FDP16_RS04630 Genome accession   NZ_CP040798
Coordinates   903044..905197 (-) Length   717 a.a.
NCBI ID   WP_176798756.1    Uniprot ID   A0A7H8V0K3
Organism   Streptococcus sanguinis strain CGMH058     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 898044..910197
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FDP16_RS04600 (FDP16_04770) - 898155..898618 (+) 464 Protein_886 N-acetyltransferase family protein -
  FDP16_RS04605 (FDP16_04775) - 898860..899201 (+) 342 WP_176798752.1 LytTR family DNA-binding domain-containing protein -
  FDP16_RS04610 (FDP16_04780) comE/blpR 899203..899943 (+) 741 WP_176798753.1 LytTR family DNA-binding domain-containing protein Regulator
  FDP16_RS11830 (FDP16_04785) - 899969..900166 (+) 198 WP_256254425.1 hypothetical protein -
  FDP16_RS04615 (FDP16_04790) - 900306..901340 (+) 1035 WP_256254426.1 sensor histidine kinase -
  FDP16_RS04620 (FDP16_04795) - 901391..901543 (-) 153 WP_176798754.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  FDP16_RS04625 (FDP16_04800) - 901668..903029 (-) 1362 WP_176798755.1 bacteriocin secretion accessory protein -
  FDP16_RS04630 (FDP16_04805) comA/nlmT 903044..905197 (-) 2154 WP_176798756.1 peptide cleavage/export ABC transporter Regulator
  FDP16_RS04635 (FDP16_04810) - 905445..905663 (+) 219 WP_176798757.1 Blp family class II bacteriocin -
  FDP16_RS04640 (FDP16_04815) - 905694..906080 (+) 387 WP_176798105.1 hypothetical protein -
  FDP16_RS04645 (FDP16_04825) - 906765..907724 (+) 960 WP_176798758.1 LPXTG cell wall anchor domain-containing protein -
  FDP16_RS04650 (FDP16_04830) - 908100..908267 (+) 168 WP_176798106.1 bacteriocin class II family protein -
  FDP16_RS04655 (FDP16_04835) - 908282..908428 (+) 147 WP_125337021.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  FDP16_RS04660 (FDP16_04840) - 908453..909100 (+) 648 WP_176798759.1 CPBP family intramembrane glutamic endopeptidase -
  FDP16_RS04665 (FDP16_04845) - 909569..909796 (+) 228 WP_176798760.1 bacteriocin class II with double-glycine leader peptide -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80720.05 Da        Isoelectric Point: 8.6580

>NTDB_id=367220 FDP16_RS04630 WP_176798756.1 903044..905197(-) (comA/nlmT) [Streptococcus sanguinis strain CGMH058]
MLKYRKSFVPQIDARDCGIAALASIAKYYGSNYSLAHLRELAKTDKEGTTALGIVKAAKEMGFETRAIKADMSLFELSDI
PYPFIAHVNKNGKLQHYYVVYKKEKKHLIIGDPDPTVKITRMGLKRFASEWTGVSIFLAPEPSYQIHRDKKIGLMSFIPL
ILRQKSLIFYIILSSLLVTLMNIVGSYYLQGILDEYIPNQMKTTLGIISIGLIITYALQQFMSFSRDYLLTILSQRLSID
VILSYIRHIFELPMSFFATRRTGEVISRFTDANSIIDALASTILSLFLDLSILIIVGCTLFLQNANLFLMTLLAIPIYII
IIFSFMKFFEKMNNEVMQANSMVSSAIIEDINGIETIKSLTSEEVRYQKIDGEFVDYLDKSFRLNKFSIIQSSLKQGAHL
ILNVSILWLGAQLVMNNHISIGQLITFNTLLSYFTNPLENIINLQTKLQSARVANNRLNEVYLVESEFAKNQPITNTSAL
AGDLSFDNVSYKYGFGRDTLSDIQITIKEGSKVSLVGISGSGKTTLAKLIVNFYEPYQGEVRINGHNLKTIDKKILRQYI
NYLPQQPYIFSGSILENLTLGANETINQSDIIQACEIAEIRSDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKSP
VLILDEATSGLDVLTEKKVIDNLMAMKEKTIIFVAHRLSISERTDQVIVLDRGKIIEIGPHKDLMEQGGFYQHLFNK

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=367220 FDP16_RS04630 WP_176798756.1 903044..905197(-) (comA/nlmT) [Streptococcus sanguinis strain CGMH058]
ATGCTCAAATATCGTAAAAGTTTTGTCCCTCAGATAGATGCTAGAGACTGCGGCATTGCTGCCTTAGCTTCTATTGCAAA
ATATTATGGTTCCAACTACTCCTTAGCACATCTGCGAGAGCTTGCCAAAACTGACAAGGAAGGCACTACAGCTCTGGGAA
TTGTCAAGGCCGCAAAGGAGATGGGGTTTGAGACACGAGCGATTAAAGCGGATATGTCGCTCTTTGAACTGTCTGATATA
CCCTATCCATTTATTGCTCATGTCAATAAAAATGGTAAACTTCAACACTACTATGTCGTCTACAAAAAAGAGAAGAAGCA
CCTTATCATCGGAGATCCAGATCCAACGGTCAAAATAACGAGGATGGGCCTAAAACGTTTTGCATCTGAGTGGACTGGAG
TGTCAATCTTTCTAGCTCCTGAACCCAGTTACCAGATTCACCGAGACAAAAAAATTGGATTAATGAGTTTTATACCGCTC
ATTCTAAGACAAAAGTCTTTGATATTCTATATAATTTTATCCAGCCTTCTTGTAACATTGATGAATATAGTGGGTTCTTA
CTACCTTCAGGGAATTCTAGATGAGTACATTCCAAATCAGATGAAAACAACTCTAGGCATTATTTCTATAGGCCTAATTA
TCACCTATGCCTTACAGCAATTCATGTCTTTTTCTAGAGACTACCTATTGACCATCCTTAGCCAACGCTTGAGTATTGAT
GTAATTTTATCCTATATTCGCCATATTTTCGAGCTCCCTATGTCCTTCTTTGCAACTAGGCGGACTGGCGAGGTTATTTC
CCGATTTACGGATGCTAACTCTATCATTGACGCTCTAGCATCCACTATATTATCTCTCTTTTTAGATTTATCTATCTTAA
TCATTGTCGGTTGCACTTTATTCCTACAAAATGCTAATTTATTTCTAATGACCTTGCTGGCAATTCCTATTTATATCATC
ATTATTTTTAGTTTTATGAAATTCTTCGAAAAAATGAATAACGAAGTGATGCAAGCGAACTCCATGGTTAGCTCTGCTAT
TATCGAAGATATTAATGGTATTGAAACGATTAAATCTTTGACTAGCGAAGAGGTCCGTTACCAAAAAATTGATGGAGAGT
TTGTAGATTATCTTGATAAGTCCTTTCGGCTCAATAAGTTTTCGATTATACAAAGTTCTTTAAAACAGGGAGCACATCTG
ATTTTAAATGTATCAATTCTTTGGTTAGGAGCTCAGCTCGTTATGAACAATCATATTTCTATCGGTCAGCTAATTACTTT
CAATACCTTGCTTTCCTATTTTACAAATCCGTTAGAAAATATTATCAACCTTCAAACTAAACTCCAATCAGCTAGAGTTG
CTAATAATCGACTAAACGAAGTATATCTAGTAGAATCTGAATTTGCAAAAAACCAGCCCATTACAAATACAAGTGCTTTA
GCTGGTGACCTTAGTTTTGATAATGTATCCTACAAGTATGGTTTTGGACGAGATACTTTATCTGATATCCAGATAACTAT
CAAAGAAGGGAGCAAGGTTAGCTTAGTCGGCATTAGCGGTTCAGGCAAGACAACTCTCGCTAAACTAATCGTCAACTTTT
ACGAACCCTATCAAGGTGAAGTTCGTATCAACGGCCATAACCTTAAGACTATTGATAAAAAAATCCTGCGCCAGTATATC
AATTACCTTCCTCAACAACCCTATATCTTTAGTGGTTCTATTCTAGAAAATCTAACCCTCGGAGCCAATGAAACTATCAA
TCAGTCTGACATTATTCAGGCTTGTGAGATTGCAGAAATTCGCTCCGATATAGAACAAATGCCTATGGGCTATCAGACAG
AGTTATCAGATGGAGCTGGATTATCTGGCGGTCAAAAACAACGAATTGCTCTGGCACGCGCACTTTTAACTAAATCTCCT
GTTCTTATCCTTGATGAAGCAACTAGCGGACTTGATGTCCTAACTGAGAAGAAAGTTATTGACAATCTAATGGCCATGAA
AGAAAAAACTATCATCTTTGTAGCTCACCGCCTTAGTATTTCTGAGCGAACCGATCAAGTGATTGTCCTTGACCGCGGCA
AAATCATTGAAATCGGCCCTCATAAAGACTTAATGGAACAGGGCGGATTCTATCAACATTTATTTAATAAATAA

Domains

Predicted by InterproScan.

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter (ABC_tran)

(500-649)

ABC transporter transmembrane region (ABC_membrane)

(168-438)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7H8V0K3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

71.13

100

0.711
  comA Streptococcus mitis NCTC 12261

66.9

99.442

0.665
  comA Streptococcus mitis SK321

66.62

99.442

0.662
  comA Streptococcus gordonii str. Challis substr. CH1

66.109

100

0.661
  comA Streptococcus pneumoniae D39

66.339

99.442

0.66
  comA Streptococcus pneumoniae R6

66.339

99.442

0.66
  comA Streptococcus pneumoniae Rx1

66.339

99.442

0.66
  comA Streptococcus pneumoniae TIGR4

65.919

99.442

0.656

Multiple sequence alignment