Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   FDP16_RS04610 Genome accession   NZ_CP040798
Coordinates   899203..899943 (+) Length   246 a.a.
NCBI ID   WP_176798753.1    Uniprot ID   A0A7H8V093
Organism   Streptococcus sanguinis strain CGMH058     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 894203..904943
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FDP16_RS04570 (FDP16_04740) hisH 894488..895111 (+) 624 WP_176798747.1 imidazole glycerol phosphate synthase subunit HisH -
  FDP16_RS04575 (FDP16_04745) hisA 895089..895811 (+) 723 WP_176799770.1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase -
  FDP16_RS04580 (FDP16_04750) hisF 895814..896572 (+) 759 WP_176798748.1 imidazole glycerol phosphate synthase subunit HisF -
  FDP16_RS04585 (FDP16_04755) hisI 896572..896916 (+) 345 WP_176798749.1 phosphoribosyl-AMP cyclohydrolase -
  FDP16_RS04590 (FDP16_04760) hisE 897046..897360 (+) 315 WP_176798750.1 phosphoribosyl-ATP diphosphatase -
  FDP16_RS04595 (FDP16_04765) - 897394..898143 (+) 750 WP_176798751.1 PHP domain-containing protein -
  FDP16_RS04600 (FDP16_04770) - 898155..898618 (+) 464 Protein_886 N-acetyltransferase family protein -
  FDP16_RS04605 (FDP16_04775) - 898860..899201 (+) 342 WP_176798752.1 LytTR family DNA-binding domain-containing protein -
  FDP16_RS04610 (FDP16_04780) comE/blpR 899203..899943 (+) 741 WP_176798753.1 LytTR family DNA-binding domain-containing protein Regulator
  FDP16_RS11830 (FDP16_04785) - 899969..900166 (+) 198 WP_256254425.1 hypothetical protein -
  FDP16_RS04615 (FDP16_04790) - 900306..901340 (+) 1035 WP_256254426.1 sensor histidine kinase -
  FDP16_RS04620 (FDP16_04795) - 901391..901543 (-) 153 WP_176798754.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  FDP16_RS04625 (FDP16_04800) - 901668..903029 (-) 1362 WP_176798755.1 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 246 a.a.        Molecular weight: 28952.33 Da        Isoelectric Point: 7.2629

>NTDB_id=367219 FDP16_RS04610 WP_176798753.1 899203..899943(+) (comE/blpR) [Streptococcus sanguinis strain CGMH058]
MKIFVLEDDLKQQFYMESTILNILKKNGWQCQFLEIYSNPQKLLDAVRERGSHQIFFLDIEIKKETQKGLEVAGQIRKLD
PYALIVFVTTHSEFMPLTFRYQVSAFDFIDKGQSEEAFIKQVEKDLAYLYERKDSFQAEETFLFENSKSEIQVPFNEIYF
FETSDVPHRLILYTKKERIEFYGQLSEIVKQDKRLYRCHRSCVVNPANIAQIDKLENIAYFPNGASCYVSRLKMKGLRAA
LKAEGK

Nucleotide


Download         Length: 741 bp        

>NTDB_id=367219 FDP16_RS04610 WP_176798753.1 899203..899943(+) (comE/blpR) [Streptococcus sanguinis strain CGMH058]
ATGAAAATCTTTGTGTTAGAAGATGATCTCAAGCAACAATTCTATATGGAGTCAACCATTCTGAATATTTTGAAAAAAAA
CGGCTGGCAATGTCAGTTTTTAGAAATCTACAGCAATCCCCAAAAGTTACTTGATGCTGTTCGGGAACGCGGAAGCCACC
AGATTTTCTTTTTGGATATTGAGATAAAAAAAGAGACACAGAAGGGCTTGGAAGTAGCTGGTCAAATTCGTAAGTTAGAT
CCCTATGCTTTGATTGTTTTTGTAACAACTCACTCAGAGTTTATGCCTTTGACTTTTCGATATCAGGTATCAGCTTTTGA
TTTTATTGATAAAGGGCAGTCTGAAGAGGCCTTTATTAAGCAGGTTGAAAAGGATCTAGCCTATCTATACGAGAGAAAGG
ATAGTTTCCAAGCTGAGGAAACCTTTCTATTTGAAAATTCCAAATCTGAAATTCAAGTTCCTTTTAATGAAATTTATTTT
TTTGAAACATCGGATGTTCCACATAGACTTATCCTCTATACAAAGAAAGAGCGTATTGAATTTTATGGACAGCTTTCTGA
GATTGTCAAGCAGGACAAGCGCCTCTATCGTTGCCACCGATCTTGTGTGGTCAATCCAGCCAATATCGCTCAAATAGATA
AATTGGAAAACATAGCTTATTTCCCCAATGGCGCTAGCTGCTATGTTTCTCGACTTAAGATGAAAGGATTGCGGGCAGCC
TTAAAAGCAGAAGGGAAGTAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7H8V093

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

57.025

98.374

0.561
  comE/comE1 Streptococcus equinus JB1

45.455

98.374

0.447
  comE/comE2 Streptococcus equinus JB1

42.975

98.374

0.423
  comE Streptococcus infantis strain Atu-4

35.878

100

0.382
  comE/comE2 Streptococcus gordonii strain NCTC7865

37.154

100

0.382
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

37.154

100

0.382

Multiple sequence alignment