Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SMUNN2025_RS04730 Genome accession   NC_013928
Coordinates   952510..953184 (+) Length   224 a.a.
NCBI ID   WP_002262214.1    Uniprot ID   Q8DU28
Organism   Streptococcus mutans NN2025     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 947510..958184
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMUNN2025_RS04710 (SmuNN2025_0908) pstB 947761..948519 (+) 759 WP_002262210.1 phosphate ABC transporter ATP-binding protein PstB -
  SMUNN2025_RS04715 (SmuNN2025_0909) phoU 948551..949204 (+) 654 WP_002262211.1 phosphate signaling complex protein PhoU -
  SMUNN2025_RS04720 (SmuNN2025_0910) - 949245..951794 (+) 2550 WP_002264508.1 M1 family metallopeptidase -
  SMUNN2025_RS04725 (SmuNN2025_0911) ciaX 952196..952459 (+) 264 WP_002262213.1 three-component system regulator CiaX -
  SMUNN2025_RS04730 (SmuNN2025_0912) ciaR 952510..953184 (+) 675 WP_002262214.1 three-component system response regulator CiaR Regulator
  SMUNN2025_RS04735 (SmuNN2025_0913) ciaH 953174..954481 (+) 1308 WP_002264510.1 three-component system sensor histidine kinase CiaH Regulator
  SMUNN2025_RS04740 (SmuNN2025_0914) rpsT 954570..954824 (-) 255 WP_011074586.1 30S ribosomal protein S20 -
  SMUNN2025_RS04745 (SmuNN2025_0915) coaA 954878..955798 (-) 921 WP_002262217.1 type I pantothenate kinase -
  SMUNN2025_RS04750 (SmuNN2025_0916) - 955894..956490 (+) 597 WP_002277834.1 class I SAM-dependent methyltransferase -
  SMUNN2025_RS04755 (SmuNN2025_0917) - 956599..957876 (+) 1278 WP_002277835.1 pyrimidine-nucleoside phosphorylase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25475.23 Da        Isoelectric Point: 4.3425

>NTDB_id=36592 SMUNN2025_RS04730 WP_002262214.1 952510..953184(+) (ciaR) [Streptococcus mutans NN2025]
MIKLLLVEDDLSLSNSIFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENNLTYGELTVDTATNTTMVNGKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKDTTFGKNLQTLRSVGYILKDAN

Nucleotide


Download         Length: 675 bp        

>NTDB_id=36592 SMUNN2025_RS04730 WP_002262214.1 952510..953184(+) (ciaR) [Streptococcus mutans NN2025]
ATGATAAAGTTATTATTAGTAGAAGACGATTTGAGTCTATCTAACTCTATCTTTGACTTTCTGGATGATTTTGCTGATGT
CATGCAGGTTTTTGATGGTGAAGAAGGACTGTATGAAGCAGAGAGTGGCGTTTATGATTTGATTCTATTAGACTTAATGC
TTCCTGAAAAAAATGGCTTCCAAGTTTTAAAAGAACTGCGTGAAAAAGGGATAACGACACCTGTTTTGATTATGACAGCT
AAGGAAGGTTTGGATGACAAAGGACACGGTTTTGAATTAGGAGCTGATGATTATCTGACAAAACCATTTTATCTTGAAGA
ATTAAAAATGCGTATTCAGGCCCTCCTCAAACGTTCAGGCAAATTCAACGAAAATAATCTGACTTACGGTGAGTTAACCG
TTGATACAGCAACTAATACAACAATGGTAAATGGAAAAGAAGTTGAACTGCTTGGCAAAGAGTTTGACTTATTAGTTTAT
TTCTTACAAAATCAAAATGTCATTTTACCTAAGTCACAAATTTTTGATCGTATCTGGGGCTTTGATAGCGATACGACAAT
TTCGGTTGTTGAAGTCTATGTTTCTAAAATAAGAAAGAAATTAAAAGACACCACATTTGGAAAGAATTTACAGACATTAC
GCAGTGTAGGATATATTTTGAAGGATGCTAATTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q8DU28

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

100

100

1
  ciaR Streptococcus pneumoniae Rx1

88.393

100

0.884
  ciaR Streptococcus pneumoniae D39

88.393

100

0.884
  ciaR Streptococcus pneumoniae R6

88.393

100

0.884
  ciaR Streptococcus pneumoniae TIGR4

88.393

100

0.884
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.611

100

0.379
  vicR Streptococcus mutans UA159

35.622

100

0.371

Multiple sequence alignment