Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   SMUNN2025_RS04735 Genome accession   NC_013928
Coordinates   953174..954481 (+) Length   435 a.a.
NCBI ID   WP_002264510.1    Uniprot ID   -
Organism   Streptococcus mutans NN2025     
Function   Required for optimal comC expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 948174..959481
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMUNN2025_RS04715 (SmuNN2025_0909) phoU 948551..949204 (+) 654 WP_002262211.1 phosphate signaling complex protein PhoU -
  SMUNN2025_RS04720 (SmuNN2025_0910) - 949245..951794 (+) 2550 WP_002264508.1 M1 family metallopeptidase -
  SMUNN2025_RS04725 (SmuNN2025_0911) ciaX 952196..952459 (+) 264 WP_002262213.1 three-component system regulator CiaX -
  SMUNN2025_RS04730 (SmuNN2025_0912) ciaR 952510..953184 (+) 675 WP_002262214.1 three-component system response regulator CiaR Regulator
  SMUNN2025_RS04735 (SmuNN2025_0913) ciaH 953174..954481 (+) 1308 WP_002264510.1 three-component system sensor histidine kinase CiaH Regulator
  SMUNN2025_RS04740 (SmuNN2025_0914) rpsT 954570..954824 (-) 255 WP_011074586.1 30S ribosomal protein S20 -
  SMUNN2025_RS04745 (SmuNN2025_0915) coaA 954878..955798 (-) 921 WP_002262217.1 type I pantothenate kinase -
  SMUNN2025_RS04750 (SmuNN2025_0916) - 955894..956490 (+) 597 WP_002277834.1 class I SAM-dependent methyltransferase -
  SMUNN2025_RS04755 (SmuNN2025_0917) - 956599..957876 (+) 1278 WP_002277835.1 pyrimidine-nucleoside phosphorylase -
  SMUNN2025_RS04760 (SmuNN2025_0918) deoC 957895..958557 (+) 663 WP_002262220.1 deoxyribose-phosphate aldolase -
  SMUNN2025_RS04765 (SmuNN2025_0919) - 958463..958933 (+) 471 WP_012997758.1 cytidine deaminase -

Sequence

Protein


Download         Length: 435 a.a.        Molecular weight: 49856.29 Da        Isoelectric Point: 9.7262

>NTDB_id=36593 SMUNN2025_RS04735 WP_002264510.1 953174..954481(+) (ciaH) [Streptococcus mutans NN2025]
MLIKLRKQKQDENISFFSHFFAVFTGIFFVMTVIIIQVMHFGIYSSVDNSLKIATENVNDYVNMTLSHNNPITEAENGDA
SFKVKSNGQMAANTDTILYDKKHNVINNVNAFSSLYHIRPKLKDIGDIVEQEAKNIYGQTEKYRTVTVKVNNDFYPQIKF
ATIVINTTQLEEANTRYVTIIISVMIVFWLISVIASVYLAKWSQKPILENYEKQKSFVENASHELRTPLAVLQNRLESLF
RKPEATILDSSESIASSLEEVRNMRMLTANLLNLARRDDGIKPEITEIQPRFFDDTFKNYEMIARENGKKLHITNKVNRQ
IKTDKTLLKQLMTILFDNAVKYTDNDGEIWLDVKTTDRSLIFSVADNGQGISDEDKKKIFDRFYRVDKARTRQKGGFGLG
LSLAKQITDSLKGSIIVKDKKPQGVMFEARLLANK

Nucleotide


Download         Length: 1308 bp        

>NTDB_id=36593 SMUNN2025_RS04735 WP_002264510.1 953174..954481(+) (ciaH) [Streptococcus mutans NN2025]
ATGCTAATTAAATTAAGAAAACAAAAGCAGGATGAGAATATTTCATTTTTCAGTCATTTCTTTGCTGTTTTTACCGGAAT
ATTCTTTGTTATGACAGTTATTATTATTCAGGTTATGCATTTTGGTATCTATTCTTCAGTTGATAATAGTCTAAAAATAG
CAACTGAGAATGTCAATGATTATGTCAATATGACTCTATCGCATAATAATCCTATTACTGAAGCTGAAAATGGAGATGCC
TCTTTTAAAGTAAAATCAAATGGCCAGATGGCTGCTAATACAGATACTATTCTTTATGATAAAAAGCATAACGTCATCAA
TAATGTCAATGCCTTCTCTTCTTTGTATCATATTCGCCCTAAACTAAAAGATATTGGTGATATTGTTGAACAAGAAGCTA
AGAATATTTACGGTCAGACCGAAAAGTATCGGACAGTGACAGTTAAGGTAAATAATGATTTTTACCCACAGATAAAATTT
GCAACGATTGTTATTAATACAACACAGCTTGAAGAGGCTAATACGCGTTATGTTACGATTATTATCAGTGTGATGATTGT
TTTTTGGCTTATATCAGTTATTGCCAGTGTTTATTTAGCGAAGTGGAGTCAAAAACCGATTCTGGAAAATTATGAAAAGC
AAAAATCATTTGTTGAAAATGCCAGTCATGAATTACGTACTCCTTTGGCTGTTTTGCAAAATCGCTTGGAGAGTTTGTTT
CGAAAACCAGAGGCTACTATCTTAGATTCTTCGGAATCTATTGCTTCTAGTTTGGAAGAGGTTAGAAACATGAGAATGCT
GACAGCAAATCTCCTTAATTTAGCCCGTCGAGATGATGGTATCAAACCAGAAATAACAGAAATTCAACCTCGTTTTTTTG
ATGATACTTTTAAAAATTATGAGATGATCGCTCGAGAAAATGGGAAAAAATTGCATATTACCAATAAGGTCAACCGTCAA
ATTAAGACAGATAAGACTTTGCTGAAGCAATTAATGACTATTCTTTTTGATAATGCTGTCAAATATACAGATAACGACGG
GGAAATTTGGCTGGACGTCAAGACAACTGATCGCAGTTTAATTTTTTCAGTTGCGGACAATGGTCAAGGTATTTCAGACG
AGGATAAGAAAAAAATTTTTGATCGTTTTTATCGCGTCGATAAAGCCAGAACACGACAAAAGGGTGGGTTCGGACTTGGT
TTGTCTTTGGCAAAACAAATAACAGACAGCTTAAAAGGCAGCATTATTGTTAAAGATAAAAAACCACAAGGAGTAATGTT
TGAAGCTCGCCTGCTTGCTAATAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(215-280)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(324-431)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus mutans UA159

99.77

100

0.998
  ciaH Streptococcus pneumoniae Rx1

55.632

100

0.556
  ciaH Streptococcus pneumoniae D39

55.632

100

0.556
  ciaH Streptococcus pneumoniae R6

55.632

100

0.556
  ciaH Streptococcus pneumoniae TIGR4

55.632

100

0.556

Multiple sequence alignment