Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   SMUNN2025_RS00335 Genome accession   NC_013928
Coordinates   59969..60883 (+) Length   304 a.a.
NCBI ID   WP_002268607.1    Uniprot ID   -
Organism   Streptococcus mutans NN2025     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 54969..65883
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMUNN2025_RS10445 - 57302..57529 (+) 228 Protein_43 phosphoribosylaminoimidazole carboxylase -
  SMUNN2025_RS00325 (SmuNN2025_0048) purB 57581..58879 (+) 1299 WP_012997508.1 adenylosuccinate lyase -
  SMUNN2025_RS00330 (SmuNN2025_0049) - 58928..59584 (+) 657 WP_012997509.1 DNA alkylation repair protein -
  SMUNN2025_RS00335 (SmuNN2025_0050) comR 59969..60883 (+) 915 WP_002268607.1 helix-turn-helix domain-containing protein Regulator
  SMUNN2025_RS00340 (SmuNN2025_0051) - 61417..63258 (-) 1842 WP_012997510.1 carbohydrate-binding domain-containing protein -
  SMUNN2025_RS00345 (SmuNN2025_0052) ruvB 63594..64589 (+) 996 WP_002269367.1 Holliday junction branch migration DNA helicase RuvB -
  SMUNN2025_RS00350 (SmuNN2025_0053) - 64627..65052 (+) 426 WP_002264681.1 low molecular weight protein-tyrosine-phosphatase -
  SMUNN2025_RS00355 (SmuNN2025_0054) - 65117..65500 (+) 384 WP_011074470.1 membrane protein -

Sequence

Protein


Download         Length: 304 a.a.        Molecular weight: 35202.33 Da        Isoelectric Point: 5.1281

>NTDB_id=36553 SMUNN2025_RS00335 WP_002268607.1 59969..60883(+) (comR) [Streptococcus mutans NN2025]
MLKDFGKKIKSLRLEKGLTKEAVCLDESQLSTRQLTRIESGQSTPTLNKAVYIAGRLGVTLGYLTDGENVELPSRYKELK
YLLLRTPTYGDQQRLAEKETYFDEIFSQFYDDLPEEEQLIIDGLQSKLDIHFSDNIDFGVGILNDYFDQILRKTNYQVND
LILIDLYFSCLTVSGLDSAIFDSRKYNQLLETLLKQVDCLPLEDLFVLNNVLLNNFGLLLELKKYDFVKQLIAVSNKIMA
RTHDFQKKPIVNLLTWKHHLFVEKDYAKAKKSYDAAILFAQLTENINLRENLEKEWQKDSQNGT

Nucleotide


Download         Length: 915 bp        

>NTDB_id=36553 SMUNN2025_RS00335 WP_002268607.1 59969..60883(+) (comR) [Streptococcus mutans NN2025]
ATGTTAAAAGATTTTGGGAAGAAAATTAAGAGCCTGAGGTTAGAAAAGGGGCTGACCAAAGAAGCTGTCTGCCTTGATGA
ATCTCAATTGTCAACACGGCAGTTGACCAGAATTGAATCAGGACAGTCTACGCCAACTCTTAATAAAGCTGTTTATATTG
CAGGACGTTTAGGAGTGACGCTTGGCTATTTAACGGACGGAGAAAATGTTGAGTTACCCAGTCGTTATAAAGAACTAAAG
TATTTATTATTACGAACGCCAACCTATGGCGACCAACAAAGATTAGCTGAAAAAGAAACCTATTTTGACGAGATTTTTAG
TCAGTTTTATGATGATTTGCCTGAAGAAGAACAATTGATTATTGATGGCTTACAATCGAAACTAGATATTCATTTTAGTG
ACAATATCGATTTTGGCGTTGGTATTTTAAATGACTATTTTGATCAGATTTTAAGAAAAACCAATTATCAGGTCAATGAT
TTGATTCTGATTGATCTCTATTTTTCCTGCTTAACTGTTAGTGGTTTGGATTCAGCTATTTTTGATTCAAGAAAATATAA
TCAATTATTGGAGACATTGCTTAAGCAGGTAGACTGCCTTCCATTGGAAGATCTTTTCGTTTTAAATAATGTTTTATTGA
ATAATTTTGGACTCCTCTTAGAATTGAAAAAATATGATTTTGTTAAGCAGCTTATTGCTGTCAGCAATAAAATCATGGCT
AGAACTCATGATTTTCAAAAAAAGCCTATTGTTAATCTTCTGACATGGAAGCATCATTTATTTGTTGAAAAAGATTATGC
GAAAGCTAAAAAGAGCTATGATGCTGCTATCTTATTTGCCCAGTTAACAGAAAACATTAATTTAAGAGAAAATTTGGAGA
AAGAATGGCAAAAAGATTCTCAGAACGGGACATAA

Domains

Predicted by InterproScan.

Helix-turn-helix (HTH_3)

(9-64)

ComR tetratricopeptide (ComR_TPR)

(73-296)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus mutans UA159

99.342

100

0.993
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

52.778

94.737

0.5
  comR Streptococcus pyogenes MGAS8232

47.02

99.342

0.467
  comR Streptococcus pyogenes MGAS315

47.157

98.355

0.464
  comR Streptococcus suis P1/7

43.478

98.355

0.428
  comR Streptococcus suis 05ZYH33

43.478

98.355

0.428
  comR Streptococcus suis D9

37

98.684

0.365

Multiple sequence alignment