Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SMI_RS04295 Genome accession   NC_013853
Coordinates   805124..805798 (+) Length   224 a.a.
NCBI ID   WP_000590638.1    Uniprot ID   D3H8A7
Organism   Streptococcus mitis B6     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 800124..810798
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMI_RS04275 (smi_0847) - 800233..800961 (+) 729 WP_012972495.1 GNAT family N-acetyltransferase -
  SMI_RS04280 (smi_0848) - 801052..801609 (+) 558 WP_001003835.1 CYTH domain-containing protein -
  SMI_RS10755 - 801622..801825 (+) 204 Protein_809 PEP-utilizing enzyme, TIM barrel domain protein -
  SMI_RS04285 (smi_0849) - 801767..802197 (+) 431 Protein_810 ASCH domain-containing protein -
  SMI_RS04290 (smi_0850) - 802319..804865 (+) 2547 WP_001149096.1 M1 family metallopeptidase -
  SMI_RS04295 (smi_0851) ciaR 805124..805798 (+) 675 WP_000590638.1 two-component system response regulator CiaR Regulator
  SMI_RS04300 (smi_0852) ciaH 805788..807122 (+) 1335 WP_000491801.1 two-component system sensor histidine kinase CiaH Regulator
  SMI_RS04305 (smi_0853) - 807151..807438 (-) 288 WP_001145228.1 DUF3270 domain-containing protein -
  SMI_RS04310 (smi_0854) - 807578..808507 (+) 930 WP_000411174.1 peptidase U32 family protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25466.34 Da        Isoelectric Point: 4.3831

>NTDB_id=36311 SMI_RS04295 WP_000590638.1 805124..805798(+) (ciaR) [Streptococcus mitis B6]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLKTLRSVGYILKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=36311 SMI_RS04295 WP_000590638.1 805124..805798(+) (ciaR) [Streptococcus mitis B6]
ATGATAAAAATCTTATTGGTTGAGGATGACCTAGGCCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCAGATGT
CATGCAGGTGTTCGATGGGGAAGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGACTTGATTTTGCTTGATTTGATGT
TGCCTGAAAAAAATGGCTTCCAAGTATTGAAAGAATTGCGTGAAAAGGGAATTACGACACCAGTTCTGATCATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACATGGTTTTGAACTAGGAGCAGATGACTATCTGACTAAACCTTTCTACCTAGAAGA
ACTCAAAATGCGGATTCAAGCCCTTCTCAAACGTTCAGGTAAATTTAATGAAAATACATTGACTTATGGAAATATTGTGG
TTAATTTGTCAACCAATACCGTTAAAGTCGAAGATACTCCTGTCGAATTGCTGGGGAAAGAGTTCGATTTATTAGTTTAT
TTCCTTCAAAATCAAAATGTTATTTTGCCTAAGACTCAGATTTTTGATCGTCTATGGGGATTTGATAGTGATACAACGAT
TTCGGTTGTCGAAGTCTATGTTTCAAAAGTCCGTAAGAAATTAAAAGGAACCACTTTTGCAGAGAATTTGAAAACCTTAC
GCAGTGTTGGGTATATTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB D3H8A7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae TIGR4

99.107

100

0.991
  ciaR Streptococcus pneumoniae D39

99.107

100

0.991
  ciaR Streptococcus pneumoniae R6

99.107

100

0.991
  ciaR Streptococcus pneumoniae Rx1

99.107

100

0.991
  ciaR Streptococcus mutans UA159

88.393

100

0.884
  vicR Streptococcus mutans UA159

35.622

100

0.371
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.283

100

0.366

Multiple sequence alignment