Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   SMI_RS04300 Genome accession   NC_013853
Coordinates   805788..807122 (+) Length   444 a.a.
NCBI ID   WP_000491801.1    Uniprot ID   D3H8A8
Organism   Streptococcus mitis B6     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 800788..812122
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMI_RS04280 (smi_0848) - 801052..801609 (+) 558 WP_001003835.1 CYTH domain-containing protein -
  SMI_RS10755 - 801622..801825 (+) 204 Protein_809 PEP-utilizing enzyme, TIM barrel domain protein -
  SMI_RS04285 (smi_0849) - 801767..802197 (+) 431 Protein_810 ASCH domain-containing protein -
  SMI_RS04290 (smi_0850) - 802319..804865 (+) 2547 WP_001149096.1 M1 family metallopeptidase -
  SMI_RS04295 (smi_0851) ciaR 805124..805798 (+) 675 WP_000590638.1 two-component system response regulator CiaR Regulator
  SMI_RS04300 (smi_0852) ciaH 805788..807122 (+) 1335 WP_000491801.1 two-component system sensor histidine kinase CiaH Regulator
  SMI_RS04305 (smi_0853) - 807151..807438 (-) 288 WP_001145228.1 DUF3270 domain-containing protein -
  SMI_RS04310 (smi_0854) - 807578..808507 (+) 930 WP_000411174.1 peptidase U32 family protein -
  SMI_RS04315 (smi_0855) - 808708..811158 (+) 2451 WP_000848727.1 bifunctional DnaQ family exonuclease/ATP-dependent helicase -

Sequence

Protein


Download         Length: 444 a.a.        Molecular weight: 50734.44 Da        Isoelectric Point: 9.1616

>NTDB_id=36312 SMI_RS04300 WP_000491801.1 805788..807122(+) (ciaH) [Streptococcus mitis B6]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAVNRATEEIKDLENAT
TDTSKTEVKPNVSSNTEVILFDKNFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRMILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEKLIVIVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENDRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGVGISTEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTITVKDNKPKGTIFEVKIAIHTPSKKKK

Nucleotide


Download         Length: 1335 bp        

>NTDB_id=36312 SMI_RS04300 WP_000491801.1 805788..807122(+) (ciaH) [Streptococcus mitis B6]
ATGTTCAGTAAACTAAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGTAACTTTGGTGTCTTCACTCTGAT
TTTCTCGACCATGACCTTGATTATTTTGCAGGTCATGCATTCGAGTCTCTATACTTCGGTGGATGATAAGCTCCATGGAC
TGAGTGAAAATCCTCAAGCAGTTATTCAGCTGGCAGTAAATAGGGCAACTGAAGAGATTAAAGATTTAGAGAATGCTACT
ACAGATACTAGTAAGACTGAGGTGAAACCCAATGTCAGTTCCAACACAGAAGTCATTCTTTTTGATAAGAATTTTACCCA
GCTCCTTTCTGGAAATCGATTTTTGGGCTTGGATAAGATTAAGTTAGAGAAAAAAGAACTAGGCCATATCTATCAGATTC
AGGTTTTTAATAGCTATGGACAAGAAGAAATCTATCGCATGATATTGATGGAAACGAATATCAGTTCGGTTTCAACCAAT
ATCAAGTATGCTGCTGTCTTGATTAATACCAGCCAGTTGGAGCAGGCCAGTCAAAAGCATGAGAAATTGATTGTGATCGT
GATGGCAAGTTTCTGGATTTTGTCTTTGCTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTCGTCCTCTGCTTGAGAGCA
TGCAGAAGCAGCAGTCCTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCTCTTGCAGTTTTGCAAAATCGTTTAGAG
ACCCTTTTTCGTAAGCCAGAAGCAACCATTATGGATGTGAGCGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAATAT
GCGTTTTTTGACGACGAACTTGTTGAATTTAGCTCGTAGAGATGATGGGATTAAGCCAGAACTTGCAGAAGTTCCAACCA
GTTTTTTCAATACGACGTTTACAAACTATGAGATGATTGCTTCTGAAAATGACCGTGTCTTCCGTTTTGAAAATCGCATC
CATCGAACGATTGTCACAGATCAGCTTTTACTAAAACAACTGATGACCATCCTATTTGATAATGCTGTCAAGTATACTGA
AGAGGATGGTGAAATTGATTTTCTTATCTCGGCGACTGATCGCAATCTGTATTTACTGGTTTCTGATAATGGAGTCGGTA
TTTCGACAGAAGATAAGAAGAAAATTTTTGATCGTTTTTATCGAGTGGACAAGGCTAGAACTCGTCAAAAAGGTGGTTTT
GGTTTAGGATTATCTCTGGCCAAGCAAATTGTAGATGCGCTTAAAGGAACCATTACTGTTAAAGATAATAAACCCAAGGG
AACAATCTTTGAAGTGAAGATTGCCATCCACACACCATCGAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(217-283)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB D3H8A8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

96.622

100

0.966
  ciaH Streptococcus pneumoniae D39

96.622

100

0.966
  ciaH Streptococcus pneumoniae R6

96.622

100

0.966
  ciaH Streptococcus pneumoniae TIGR4

96.622

100

0.966
  ciaH Streptococcus mutans UA159

55.632

97.973

0.545

Multiple sequence alignment