Detailed information    

insolico Bioinformatically predicted

Overview

Name   comB   Type   Regulator
Locus tag   SMI_RS00325 Genome accession   NC_013853
Coordinates   65088..66437 (+) Length   449 a.a.
NCBI ID   WP_000801593.1    Uniprot ID   -
Organism   Streptococcus mitis B6     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 60088..71437
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMI_RS00300 (smi_0059.1) - 60702..60830 (+) 129 WP_000658145.1 smi_0059.1 family bacteriocin-like peptide -
  SMI_RS10535 (smi_0059.2) - 60842..60997 (+) 156 WP_001004585.1 hypothetical protein -
  SMI_RS00305 (smi_0060) - 61031..61228 (+) 198 WP_000180818.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  SMI_RS00310 (smi_0061) - 61442..61597 (+) 156 WP_000357249.1 smi_0061 family bacteriocin-like peptide -
  SMI_RS10960 (smi_0062) - 61601..61816 (+) 216 WP_012972421.1 bacteriocin immunity protein -
  SMI_RS10670 - 61896..62075 (+) 180 WP_231840221.1 hypothetical protein -
  SMI_RS00315 (smi_0063) - 62154..62360 (+) 207 WP_000673799.1 bacteriocin immunity protein -
  SMI_RS00320 (smi_0064) comA 62922..65075 (+) 2154 WP_000668317.1 peptide cleavage/export ABC transporter ComA Regulator
  SMI_RS00325 (smi_0065) comB 65088..66437 (+) 1350 WP_000801593.1 competence pheromone export protein ComB Regulator
  SMI_RS00330 (smi_0066) purC 66608..67315 (+) 708 WP_164925502.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  SMI_RS10965 - 67317..67460 (+) 144 WP_343287568.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  SMI_RS11015 - 67537..67605 (+) 69 Protein_63 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  SMI_RS00335 (smi_0067) - 67660..71385 (+) 3726 WP_000361183.1 phosphoribosylformylglycinamidine synthase -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 49767.71 Da        Isoelectric Point: 5.4063

>NTDB_id=36282 SMI_RS00325 WP_000801593.1 65088..66437(+) (comB) [Streptococcus mitis B6]
MKPEFLESAEFYNRRYHNFSSRVIVPMSLLLVFLLGFATFAEKEMSLSTRATVEPSRILANIQSTSNNRILVNHLEENKL
VKKGELLLQYQEGAEGVQAEAYASQLDMLKDQKKQLEYLQKSLQEGTDYFPEEDKFGYQATFRDYISQAGSLRASTSQQN
ETIASQNAAASQTQAEIGNLISQAEAKIRDYQTAKSAIETGASLGNQNLAYSLYQSYKSQGEENPQAKAQAVAQVEAQLS
QLESSLATYRVQYAGSGSQQAYASGLSSQLESLKSQHLAKVGQELTLLDQKILEVESGKKVQGNLLDKGKITASEDGVLH
LNPETSDSSMVAEGALLAQLYPSLEKEGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAKNQLFLDSTITSIDATATKTEK
GNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=36282 SMI_RS00325 WP_000801593.1 65088..66437(+) (comB) [Streptococcus mitis B6]
ATGAAACCAGAATTTTTAGAAAGTGCGGAGTTTTATAATCGTCGTTACCATAATTTTTCCAGTCGGGTGATTGTGCCCAT
GTCCCTTCTACTCGTGTTTTTGCTTGGATTTGCAACATTTGCAGAGAAGGAGATGAGTTTGTCTACTAGAGCTACTGTTG
AGCCTAGTCGTATCCTTGCAAATATCCAGTCAACTAGCAACAATCGCATTCTTGTCAATCATTTGGAAGAAAATAAGCTG
GTTAAGAAGGGGGAACTTCTGCTTCAATATCAGGAAGGGGCAGAGGGTGTCCAAGCGGAGGCCTATGCTAGTCAGTTGGA
CATGCTCAAGGATCAAAAAAAGCAATTGGAGTATTTGCAAAAGAGCCTGCAAGAAGGGACGGATTACTTTCCAGAGGAGG
ATAAGTTTGGCTACCAAGCCACCTTTCGCGACTACATCAGTCAAGCAGGAAGTCTTAGGGCTAGTACATCGCAACAAAAC
GAGACCATCGCGTCCCAGAATGCAGCAGCTAGTCAAACCCAAGCTGAAATCGGCAACCTCATCAGTCAAGCAGAGGCTAA
AATTCGCGATTACCAGACAGCTAAGTCAGCTATTGAAACAGGCGCTTCCTTGGGCAATCAGAATCTAGCCTACTCTCTCT
ACCAGTCCTATAAGTCTCAGGGTGAGGAAAATCCGCAAGCTAAAGCTCAGGCTGTTGCGCAGGTTGAAGCACAGCTTTCT
CAGTTAGAATCTAGTCTTGCTACTTACCGTGTCCAGTATGCGGGTTCAGGTAGCCAGCAAGCCTATGCGTCTGGTTTAAG
CAGTCAATTGGAGTCTCTCAAATCCCAACACTTGGCAAAGGTTGGTCAGGAATTGACCCTTCTAGACCAGAAAATCTTGG
AGGTGGAGTCAGGTAAGAAGGTACAGGGAAATCTTTTAGACAAGGGGAAAATTACGGCGAGTGAGGATGGGGTACTTCAT
CTTAATCCTGAGACCAGTGATTCTAGCATGGTTGCAGAAGGTGCCCTACTAGCCCAACTCTATCCGTCCTTGGAGAAAGA
AGGGAAAGCTAAACTCACAGCTTATCTAAGTTCGAAAGACGTAGCAAGGATCAAGGTCGGTGATTCTGTTCGTTATACGA
CGACTCATGATGCCAAGAATCAACTTTTCCTAGATTCTACTATTACAAGTATAGATGCGACAGCTACTAAGACTGAGAAA
GGGAATTTCTTTAAAATTGAGGCGGAGACTAATCTAACTTCGGAGCAGGCTGAAAAACTTCGGTACGGGGTGGAAGGTCG
CCTGCAGATGATTACGGGCAAGAAAAGTTACCTACGTTATTATTTAGATCAATTTTTGAACAAAGAGTAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB Streptococcus mitis SK321

96.437

100

0.964
  comB Streptococcus pneumoniae TIGR4

95.1

100

0.951
  comB Streptococcus pneumoniae D39

94.878

100

0.949
  comB Streptococcus pneumoniae R6

94.878

100

0.949
  comB Streptococcus pneumoniae Rx1

94.878

100

0.949
  comB Streptococcus mitis NCTC 12261

94.655

100

0.947
  comB Streptococcus gordonii str. Challis substr. CH1

55.333

100

0.555

Multiple sequence alignment