Detailed information NTG0036281

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: SMI_RS00320
• Genome accession: NC_013853
• Coordinates: 62922..65075 (+)
• Length: 717 a.a.
• NCBI ID: WP_000668317.1
• Uniprot ID: D3H675
• Organism: Streptococcus mitis B6
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 57922..70075

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SMI_RS00285 (smi_0057.1)	-	57965..58111 (+)	147	WP_000425304.1	smi_0057.1 family bacteriocin-like peptide	-
SMI_RS10665	-	58676..59491 (+)	816	WP_000184941.1	GHKL domain-containing protein	-
SMI_RS00295 (smi_0059)	-	59488..60219 (+)	732	WP_001221865.1	response regulator transcription factor	-
SMI_RS00300 (smi_0059.1)	-	60702..60830 (+)	129	WP_000658145.1	smi_0059.1 family bacteriocin-like peptide	-
SMI_RS10535 (smi_0059.2)	-	60842..60997 (+)	156	WP_001004585.1	hypothetical protein	-
SMI_RS00305 (smi_0060)	-	61031..61228 (+)	198	WP_000180818.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
SMI_RS00310 (smi_0061)	-	61442..61597 (+)	156	WP_000357249.1	smi_0061 family bacteriocin-like peptide	-
SMI_RS10960 (smi_0062)	-	61601..61816 (+)	216	WP_012972421.1	bacteriocin immunity protein	-
SMI_RS10670	-	61896..62075 (+)	180	WP_231840221.1	hypothetical protein	-
SMI_RS00315 (smi_0063)	-	62154..62360 (+)	207	WP_000673799.1	bacteriocin immunity protein	-
SMI_RS00320 (smi_0064)	comA	62922..65075 (+)	2154	WP_000668317.1	peptide cleavage/export ABC transporter ComA	Regulator
SMI_RS00325 (smi_0065)	comB	65088..66437 (+)	1350	WP_000801593.1	competence pheromone export protein ComB	Regulator
SMI_RS00330 (smi_0066)	purC	66608..67315 (+)	708	WP_164925502.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
SMI_RS10965	-	67317..67460 (+)	144	WP_343287568.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
SMI_RS11015	-	67537..67605 (+)	69	Protein_63	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80228.26 Da
• Isoelectric Point: 6.3889

>NTDB_id=36281 SMI_RS00320 WP_000668317.1 62922..65075(+) (comA) [Streptococcus mitis B6]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYSLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFAEEWTGVTLFMAPSPDYKPHKDQKNGLLSFIPI
LVKQRGLIANIVLATLLVTLINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGEMTFKQVSYKYGYGRDVLSDINLTIPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS

Nucleotide

• Length: 2154 bp

>NTDB_id=36281 SMI_RS00320 WP_000668317.1 62922..65075(+) (comA) [Streptococcus mitis B6]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAGGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGCTATTATTCTTTGGCTCATTTGCGAGAATTGGCTAAGACGACCATGGATGGGACGACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGTTTTGAGACGCGAGCAATTAAGGCGGATATGACGCTTTTTGACTTGCCAGATTTG
ACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAAGGAAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGACAG
CATTCATATTGCCGATCCAGATCCTGGGGTGAAATTGACCAAACTGCCACGTGAGCGTTTTGCGGAAGAATGGACAGGGG
TGACTCTTTTTATGGCACCTAGTCCAGACTACAAGCCTCATAAGGATCAAAAGAATGGTTTACTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAATATCGTTTTGGCAACACTCTTGGTAACCTTGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGACACCTATGTGCCAGATCAGATGCGTTCGACGCTGGGGATTATTTCTATTGGGCTGGTGA
TTGTTTATATTCTTCAGCAAATCTTGTCTTACGCTCAGGAGTATCTCTTACTTGTTTTGGGGCAACGCTTATCGATTGAT
GTGATTTTGTCCTATATCAAGCATGTTTTTCACCTGCCTATGTCCTTCTTTGCGACACGCAGGACAGGGGAGATCGTGTC
TCGTTTTACAGATGCCAATAGTATTATTGATGCGCTGGCTTCGACCATTCTTTCGATTTTCCTAGATGTGTCAACGGTTG
TCATTATTTCACTTGTTTTATTTTCACAAAATACCAATCTCTTTTTCATGACCTTATTGGCGCTTCCTATCTATACAGTG
ATTATCTTTGCCTTTATGAAGCCGTTTGAAAAGATGAATCGGGATACCATGGAAGCCAATGCGGTTCTGTCTTCTTCTAT
CATTGAGGACATCAACGGTATTGAGACTATCAAGTCTTTGACCAGTGAAAGTCAACGTTACCAAAAGATTGACAAGGAAT
TTGTAGATTATCTGAAAAAATCCTTTACCTATAGTCGGGCAGAGAGTCAGCAAAAGGCTCTGAAAAAGGTTGCCCATCTC
TTGCTCAATGTCGGCATTCTCTGGATGGGGGCTGTTCTGGTCATGGATGGCAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTGGTTTACTTTACCAATCCTTTGGAGAATATCATCAACCTGCAAACTAAGCTTCAGACAGCGCAGGTTG
CCAATAACCGTCTAAATGAGGTTTATCTGGTAGCTTCTGAGTTTGAGGAGAAGAAAACAGTTGAGGATTTGAGCTTGATG
AAGGGAGAGATGACCTTCAAGCAGGTTTCCTACAAGTATGGCTATGGTCGAGATGTCTTGTCAGACATCAATTTGACCAT
TCCCCAAGGTTCTAAAGTGGCTTTTGTGGGAATTTCAGGGTCAGGTAAGACGACCTTGGCTAAGATGATGGTTAATTTTT
ACGACCCAAGTCAAGGGGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAAGCCCTGCGCCAGTATATC
AACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTAGAGAATCTTCTTTTGGGAGCCAAGGAAGGGACGAC
TCAGGAGGATATCTTACGGGCGGTCGAATTGGCAGAGATTCGAGAGGACATTGAGCGGATGCCACTGAATTACCAGACAG
AATTGACTTCGGATGGGGCAGGTATCTCAGGTGGTCAACGGCAGAGAATTGCTCTGGCGCGTGCTCTCTTGACAGATGCG
CCGGTCTTGATTTTGGATGAGGCGACCAGTAGTTTGGATATCTTGACAGAGAAGCGGATTGTGGATAATCTCATGGCTTT
AGATAAGACCTTGATTTTCATCGCCCACCGCTTGACCATTGCTGAACGGACAGAGAAGGTTGTTGTCTTGGATCAGGGCA
AGATTGTTGAAGAAGGAAAGCATGCTGATTTACTTGCACAGGGTGGCTTTTATGCCCATTTGGTGAATAGCTAG

Domains

Predicted by InterproScan.

• ABC transporter (ABC_tran) (500-650)

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter transmembrane region (ABC_membrane) (170-438)

3D structure

• AlphaFold DB: D3H675

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	99.303	100	0.993
comA	Streptococcus mitis SK321	99.163	100	0.992
comA	Streptococcus pneumoniae Rx1	98.884	100	0.989
comA	Streptococcus pneumoniae D39	98.884	100	0.989
comA	Streptococcus pneumoniae R6	98.884	100	0.989
comA	Streptococcus pneumoniae TIGR4	98.466	100	0.985
comA	Streptococcus gordonii str. Challis substr. CH1	80.893	100	0.809
comA/nlmT	Streptococcus mutans UA159	65.272	100	0.653